Synthesis and in vitro evaluation of 4-substituted-1-azaanthraquinones

Archives of Pharmacal Research

Volumn 21, Issue 1, 1998, Pages 73-75

  Lee, Heesoon ^a   Hong, Seoung Soo ^a   Choi, Jae Young ^a   Cho, Jungsook ^b   Kim, Young Ho ^c  

^a Chungbuk National University   (South Korea)

^b Dongguk University College of Medicine   (South Korea)

^c Chungnam National University   (South Korea)

Author keywords

Antitumor agents; Azaanthraquinone; Bio reductive activation; Cytotoxic activity; Doxorubicin; Hetero Diels Alder reaction; Mitoxantrone

Indexed keywords

ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC ANTIBIOTIC; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; HETEROCYCLIC COMPOUND;

ARTICLE; CELL CULTURE; DRUG SCREENING; HUMAN; SYNTHESIS; THIN LAYER CHROMATOGRAPHY;

ANTHRAQUINONES; ANTIBIOTICS, ANTINEOPLASTIC; AZA COMPOUNDS; CHROMATOGRAPHY, THIN LAYER; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDICATORS AND REAGENTS; TUMOR CELLS, CULTURED;

EID: 0031987953     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03216757     Document Type: Article

References (8)

1. Chigr, M., Fillion, H., and Rougny, A., A Regioselective Synthesis of 4,5- and 4,8-Disubstitutedazaanthraquinones by Diels-Alder Route, Tetrahedron Lett., 29, 5913-5916, (1988).
2. Gandolfi, C. A., Beggiolin, G., Menta. E., Palumbo, M., Sissi, C., Spinelli, S, Johnson, F., Chromophore-Modified Antitumor Anthracenediones: Synthesis, DNA Binding, and Cytotoxic Activity of 1,4-Bis [(aminoalkyl)amino]benzo[g]phthalazine-5,10-diones, J. Med. Chem., 38, 526-536, (1995) and references therein.
3. Lee, H. and Anderson, W. K., Total Synthesis of 4-Acetoxymethyl-1,6,9-trimethyl-1,9-diazaanthracene-2,5,8,10-tetraone, A Nybomycin Acetate Analogue. Tetrahedron Lett., 31, 4405-4408, (1990).
4. Lee, H., Hong, S-.S. and Kim, Y-. H., Synthesis and In Vitro Evaluation of 3-Substituted-1-azaanthraquinones, Bio. Med. Chem. Lett., 6, 933-936, (1996).
5. Priebe, W. Ed. Anthracycline Antibiotics, ACS symposium series 574, Am. Chem. Soc., Washington, DC, 1995 and references cited therein.
6. Skehan, P., Storeng, R., Scudiero, D, Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenny, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer Inst., 82, 1107-12 (1990).
7. Surato, A., Angelucci, F., and Gargiotti, A. Antitumor Anthracyclines, Chimicaoggi, 1990, April, 9-19, and references cited therein.
8. Wakelin, L P. G. and Waring, M. J. DNA Intercalating Agents, In Comprehensive Medicinal Chemistry, Vol 2, 703-724; Hansch, C. Sammes, P. G., Taylor, J. B., Eds.; Pergamon Press: New York, (1990), and references cited therein.