AUC and c(max) are not sufficient to prove bioequivalence

Pharmacological Research

Volumn 37, Issue 2, 1998, Pages 93-95

  Rescigno, Aldo ^a,c   Powers, Jean D ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b NATIONWIDE CHILDREN S HOSPITAL   (United States)

^c NONE   (United States)

Author keywords

Area under the curve; Bioequivalence; Maximum concentration; Pharmacokinetics

Indexed keywords

AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; DRUG ABSORPTION; DRUG CONCENTRATION; MATHEMATICAL MODEL; PRIORITY JOURNAL; MATHEMATICAL COMPUTING; PHARMACOKINETICS;

AREA UNDER CURVE; MATHEMATICAL COMPUTING; PHARMACOKINETICS; THERAPEUTIC EQUIVALENCY;

EID: 0031987387     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1997.0277     Document Type: Article

References (4)

1. 1. Rescigno A, Marzo A. Area under the curve, bioavailability, and clearance. J Pharmacokin Biopharm 1991; 19: 473-80.
2. 2. Zilversmit DB, Entenman C, Fishier MC. On the calculation of turnover time and turnover rate from experiments involving the use of labeling agents. J Gen Physiol 1943; 26: 325.
3. 3. Rescigno A. Segre G. Drug and tracer kinetics. Walthan (MA): Blaisdell, 1966, Ch. 6.
4. 4. Melnick D, Hochberg M, Oser BL. Physiological availability of the vitamins. J Nutrition 1945; 30: 81-8.