Evidence of ABC transporters in fresh tumor cells from patients with ovarian cancer

International Journal of Clinical Pharmacology and Therapeutics

Volumn 36, Issue 2, 1998, Pages 64-66

  Sargent, J M ^a,c   Coley, H M ^b   Williamson, C ^a   Taylor, C ^a  

^a Pembury Hospital   (United Kingdom)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c Pembury Hospital   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; DOXORUBICIN; GLYCOPROTEIN P;

ASCITES FLUID; CANCER CELL; CANCER SURVIVAL; CLINICAL ARTICLE; CONFERENCE PAPER; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; MULTIDRUG RESISTANCE; OVARY CANCER; PROTEIN EXPRESSION;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CYCLOSPORINS; DAUNORUBICIN; DRUG RESISTANCE, MULTIPLE; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; P-GLYCOPROTEIN; TUMOR CELLS, CULTURED; VAULT RIBONUCLEOPROTEIN PARTICLES;

EID: 0031985238     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (13)

1. Bailly J-D, Muller C, Jaffrezou J-P et al 1995 Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines. Leukemia 9: 799-807
2. Broxterman HJ, Sonneveld P, Feller N et al 1996 Quality control of multidrug resistance assays in adult acute leukemia: Correlation between assays for P-glycoprotein expression and activity. Blood 87: 4809-4816
3. Cole SPC, Bhardwaj G, Gerlach JH et al 1992 Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258: 1650-1654
4. Friedländer ML 1992 Drug resistance in ovarian cancer. Int J Gynecol Cancer 1 (Suppl): 2-9
5. Izquierdo MA, Neefjes JJ, Mathari AEL, Flens MJ, Scheffer GL, Scheper RJ 1996 Overexpression of the ABC transporter TAP in multidrug-resistant human cancer cell lines. Br J Cancer 74: 1961-1967
6. Juliano RL, Ling V 1976 A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455: 152-162
7. Kavallaris M, Leary JA, Barrett JA, Friedländer ML 1996 MDR1 and multidrug resistance-associated protein (MRP) gene expression in epithelial ovarian tumours. Cancer Letts 102: 7-16
8. List AF, Spier CS, Grogan TM et al 1996 Overexpression of the major vault protein lung-resistance protein predicts treatment outcome in acute myeloid leukaemia. Blood 87: 2464-2469
9. Michieli M, Damiani D, Ermacora A et al 1997 P-glycoprotein (PGP) and lung: resistance-related protein (LRP) expression and function in leukaemic blast cells. Br J Haematol 96: 356-365
10. Ozols RF 1992 Chemotherapy for advanced epithelial ovarian cancer. Haem/Oncol Clin North Am 6: 879-894
11. Scheper RJ, Broxterman HJ, Scheffer GL et al 1993 Overexpression of a Mr 110,000 vesicular protein in non-p-glycoprotein-mediated multidrug resistance. Cancer Res 53: 1475-1479
12. Wei LY, Stutts MJ, Hoffman MM, Roepe PD 1995 Overexpression of the cystic fibrosis transmembrane conductance regulator in NIH 3T3 cells lowers membrane potential and intracellular pH and confers a multidrug resistance phenotype. Biophys 169: 883-895
13. Wilson JK, Sargent JM, Elgie AW, Hill JG, Taylor CG 1990 A feasibility study of the MTT assay for chemosensitivity testing in ovarian malignancy. Br J Cancer 62: 189-194