Automation of the liquid-phase synthesis of biopolymers

Journal of Chemical Technology and Biotechnology

Volumn 71, Issue 1, 1998, Pages 77-83

  Bagno, Andrea ^a   Bicciato, Silvio ^a   Di Bello, Carlo ^a   Bonora, Gian Maria ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Automation; Biopolymers synthesis; Liquid phase; Solid phase

Indexed keywords

BIOPOLYMERS; COMPUTER CONTROL; COMPUTER SOFTWARE; DISSOLUTION; ESTERS; OLIGOMERS; ORGANIC SOLVENTS; PRECIPITATION (CHEMICAL); SOLUBILITY;

LIQUID PHASE SYNTHESIS; OLIGONUCLEOTIDES;

BIOSYNTHESIS;

BIOPOLYMER; OLIGONUCLEOTIDE;

APPARATUS; ARTICLE; AUTOMATION; CHEMICAL REACTION; COMPUTER PROGRAM; DISSOLUTION; METHODOLOGY; PRECIPITATION; PURIFICATION; SYNTHESIS; TIME;

EID: 0031984071     PISSN: 02682575     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4660(199801)71:1<77::AID-JCTB778>3.0.CO;2-A     Document Type: Article

References (11)

1. Merrifield, R. B., Solid phase peptide synthesis. I. The synthesis of a tetrapeptide. J. Am. Soc., 85 (1963) 2149-54.
2. Merrifield, R. B., The automatic synthesis of protein. Sci. Am., 218 (1968) 56-62, 67-72.
3. Merrifield, R. B., Solid phase synthesis. Science, 232 (1986) 341-7.
4. Harris, J. M., Introduction to biotechnical and biomedical applications of poly(ethylene glycol). In Poly(ethylene Glycol) Chemistry. Biotechnical and Biomedical Applications, ed. J. M. Harris. Plenum Press, New York, 1992, pp. 1-14.
5. Bayer, E. & Mutter, M., Liquid phase synthesis of peptides. Nature, 237 (1972) 512-13.
6. Bonora, G. M., Polyethylene glycol. A high-efficiency liquid phase (HELP) for the large-scale synthesis of the oligonucleotides. Appl. Biochem. and Biotech., 54 (1995) 3-17.
7. Douglas, S. P., Whitfield, D. M. & Krepinsky, J. J., Polymer-supported solution synthesis of oligosaccarides. J. Am. Chem. Soc., 113 (1991) 5095-7.
8. Han, H., Wolfe, M. M., Brenner, S. & Janda, K. D., Liquid-phase combinatorial synthesis. Proc. Natl Acad. Sci. USA, 92 (1995) 6419-23.
9. Bicciato, S., Bagno, A., Buso, O., Dettin, M. & Di Bello, C., An improved system for automated peptides synthesis. Chem. Eng. Technol., 18 (1995) 210-15.
10. Bagno, A., Bicciato, S., Buso, O., Di Bello, C., Biancotto, G., Maffini, M., Scremin, C. L. & Bonora, G. M., A batch-type system for large-scale solid-phase oligonucleotide synthesis. Chem. Biochem. Eng. Q., 8 (1995) 183-8.
11. Bagno, A., Bicciato, S., Dal Bosco, M., Bonora, G. M. & Di Bello, C., Italian Patent MI96A001301, 1996.