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Volumn 86, Issue 1, 1998, Pages 72-80

V gene sequences of lupus-derived human IgM anti-ssDNA antibody: Implication for the importance of the location of DNA-binding amino acids

Author keywords

Anti DNA; Autoimmunity; Human; Somatic mutation; V gene

Indexed keywords

DNA ANTIBODY; IMMUNOGLOBULIN M;

EID: 0031983985     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1997.4448     Document Type: Article
Times cited : (3)

References (42)
  • 1
    • 0020022930 scopus 로고
    • Autoantibodies to nuclear antigens (ANA): Their immunobiology and medicine
    • Tan E. M. Autoantibodies to nuclear antigens (ANA): Their immunobiology and medicine. Adv. Immunol. 33:1982;167-240.
    • (1982) Adv. Immunol. , vol.33 , pp. 167-240
    • Tan, E.M.1
  • 2
    • 0023638145 scopus 로고
    • Relationship of human variable region heavy chain germ-line genes to genes encoding anti-DNA autoantibodies
    • Dersimonian H., Schwartz R. S., Barrett K. J., Stollar B. D. Relationship of human variable region heavy chain germ-line genes to genes encoding anti-DNA autoantibodies. J. Immunol. 139:1987;2496-2501.
    • (1987) J. Immunol. , vol.139 , pp. 2496-2501
    • Dersimonian, H.1    Schwartz, R.S.2    Barrett, K.J.3    Stollar, B.D.4
  • 3
    • 0024164631 scopus 로고
    • A 16/6 idiotype-positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation
    • Chen P. P., Liu M. F., Sinha S., Carson D. A. A 16/6 idiotype-positive anti-DNA antibody is encoded by a conserved VH gene with no somatic mutation. Arthritis Rheum. 31:1988;1429-1431.
    • (1988) Arthritis Rheum. , vol.31 , pp. 1429-1431
    • Chen, P.P.1    Liu, M.F.2    Sinha, S.3    Carson, D.A.4
  • 4
    • 0024395617 scopus 로고
    • Analysis of variable region genes encoding a human anti-DNA antibody of normal origin
    • Cairns E., Kwong P. C., Misener V., Peter I. P., Bell D. A., Siminovitch K. A. Analysis of variable region genes encoding a human anti-DNA antibody of normal origin. J. Immunol. 143:1990;685-691.
    • (1990) J. Immunol. , vol.143 , pp. 685-691
    • Cairns, E.1    Kwong, P.C.2    Misener, V.3    Peter, I.P.4    Bell, D.A.5    Siminovitch, K.A.6
  • 5
    • 0027156463 scopus 로고
    • Human B-cell clones expressing lupus nephritis-associated anti-DNA idiotypes are preferentially expanded without somatic mutation
    • Hirabayashi Y., Munakata Y., Takai O., Shibata S., Sasaki T., Sano H. Human B-cell clones expressing lupus nephritis-associated anti-DNA idiotypes are preferentially expanded without somatic mutation. Scand. J. Immunol. 37:1993;533-540.
    • (1993) Scand. J. Immunol. , vol.37 , pp. 533-540
    • Hirabayashi, Y.1    Munakata, Y.2    Takai, O.3    Shibata, S.4    Sasaki, T.5    Sano, H.6
  • 6
    • 0028258388 scopus 로고
    • Identification and characterization of a new human DNA monoclonal antibody and a common idiotype, WRI 176 Id β
    • Blanco F., Longhurst C., Watts R., Kalsi J., Wiloch H. W., Youinou P., Latchman D. S., Isenberg D. A. Identification and characterization of a new human DNA monoclonal antibody and a common idiotype, WRI 176 Id β Lupus. 3:1994;15-24.
    • (1994) Lupus , vol.3 , pp. 15-24
    • Blanco, F.1    Longhurst, C.2    Watts, R.3    Kalsi, J.4    Wiloch, H.W.5    Youinou, P.6    Latchman, D.S.7    Isenberg, D.A.8
  • 7
    • 0029995119 scopus 로고    scopus 로고
    • V gene sequences of human anti-ssDNA antibodies secreted by lupus-derived CD5-negative B cell hybridomas
    • Mitamura K., Suenaga R., Wilson K. B., Abdou N. I. V gene sequences of human anti-ssDNA antibodies secreted by lupus-derived CD5-negative B cell hybridomas. Clin. Immunol. Immunopathol. 78:1996;152-160.
    • (1996) Clin. Immunol. Immunopathol. , vol.78 , pp. 152-160
    • Mitamura, K.1    Suenaga, R.2    Wilson, K.B.3    Abdou, N.I.4
  • 8
    • 0028157110 scopus 로고
    • Somatic diversification in the heavy chain variable genes expressed by human autoantibodies bearing a lupus-associated nephritogenic anti-DNA idiotype
    • Demaison C., Chastagner P., Theze J., Zouali M. Somatic diversification in the heavy chain variable genes expressed by human autoantibodies bearing a lupus-associated nephritogenic anti-DNA idiotype. Proc. Natl. Acad. Sci. USA. 91:1994;514-518.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 514-518
    • Demaison, C.1    Chastagner, P.2    Theze, J.3    Zouali, M.4
  • 11
    • 0026761402 scopus 로고
    • Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB × NZW)F1 mice
    • Tillman D. M., Jou N.-T., Hill R. J., Marion T. N. Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB × NZW)F1 mice. J. Exp. Med. 176:1992;761-779.
    • (1992) J. Exp. Med. , vol.176 , pp. 761-779
    • Tillman, D.M.1    Jou, N.-T.2    Hill, R.J.3    Marion, T.N.4
  • 13
    • 0023718496 scopus 로고
    • V region sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW F1 mice
    • Eilat D., Webster D. M., Ress A. R. V region sequences of anti-DNA and anti-RNA autoantibodies from NZB/NZW F1 mice. J. Immunol. 141:1988;1745-1753.
    • (1988) J. Immunol. , vol.141 , pp. 1745-1753
    • Eilat, D.1    Webster, D.M.2    Ress, A.R.3
  • 14
    • 0028172241 scopus 로고
    • Isolated VH4 heavy chain variable regions bind DNA: Characterization of a recombinant antibody heavy chain library derived from patients with active SLE
    • Kieber-Emmons T., von Feldt J. M., Gogillot A. P., McCallus D., Srikantan V., Weiner D. B., Williams W. V. Isolated VH4 heavy chain variable regions bind DNA: Characterization of a recombinant antibody heavy chain library derived from patients with active SLE. Lupus. 3:1994;379-392.
    • (1994) Lupus , vol.3 , pp. 379-392
    • Kieber-Emmons, T.1    Von Feldt, J.M.2    Gogillot, A.P.3    McCallus, D.4    Srikantan, V.5    Weiner, D.B.6    Williams, W.V.7
  • 16
    • 0028074657 scopus 로고
    • Mutational analysis of an autoantibody: Differential binding and pathogenicity
    • Katz J. B., Limpanasithikul W., Diamond B. Mutational analysis of an autoantibody: Differential binding and pathogenicity. J. Exp. Med. 180:1994;925-932.
    • (1994) J. Exp. Med. , vol.180 , pp. 925-932
    • Katz, J.B.1    Limpanasithikul, W.2    Diamond, B.3
  • 17
    • 0026353150 scopus 로고
    • Idiotypic and immunochemical differences of anti-DNA antibodies of a lupus patient during active and inactive disease
    • Suenaga R., Evans M., Abdou N. I. Idiotypic and immunochemical differences of anti-DNA antibodies of a lupus patient during active and inactive disease. Clin. Immunol. Immunopathol. 61:1991;320-331.
    • (1991) Clin. Immunol. Immunopathol. , vol.61 , pp. 320-331
    • Suenaga, R.1    Evans, M.2    Abdou, N.I.3
  • 18
    • 0002486655 scopus 로고
    • Preparation of genomic DNA
    • New York: Green Publishing Associates and Wiley-Interscience. p. 2.1.1-2.1.6
    • Treco D. A. Preparation of genomic DNA. Current Protocols in Molecular Biology. 1992;Green Publishing Associates and Wiley-Interscience, New York. p. 2.1.1-2.1.6.
    • (1992) Current Protocols in Molecular Biology
    • Treco, D.A.1
  • 19
    • 0003331946 scopus 로고
    • Generation of Epstein-Barr virus (EBV)-immortalized B cell line
    • J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, & W. Strober. New York: Green Publishing Associates and Wiley-Interscience
    • Tosato G. Generation of Epstein-Barr virus (EBV)-immortalized B cell line. Coligan J. E., Kruisbeek A. M., Margulies D. H., Shevach E. M., Strober W. Current Protocols in Immunology. 1992;7221-7223 Green Publishing Associates and Wiley-Interscience, New York.
    • (1992) Current Protocols in Immunology , pp. 7221-7223
    • Tosato, G.1
  • 21
    • 0023010596 scopus 로고
    • Study of anti-DNA antibodies prepared by DNA cellulose or Cibacron blue chromatography
    • Suenaga R., Evans M., Hatfield M., Abdou N. I. Study of anti-DNA antibodies prepared by DNA cellulose or Cibacron blue chromatography. J. Immunol. Methods. 93:1986;131-140.
    • (1986) J. Immunol. Methods , vol.93 , pp. 131-140
    • Suenaga, R.1    Evans, M.2    Hatfield, M.3    Abdou, N.I.4
  • 22
    • 0027024892 scopus 로고
    • Lupus-derived human monoclonal IgM anti-DNA antibody displays monospecificity, high affinity, and private idiotype specificity
    • Suenaga R., Abdou N. I. Lupus-derived human monoclonal IgM anti-DNA antibody displays monospecificity, high affinity, and private idiotype specificity. Lupus. 1:1992;363-368.
    • (1992) Lupus , vol.1 , pp. 363-368
    • Suenaga, R.1    Abdou, N.I.2
  • 23
    • 0025011254 scopus 로고
    • The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germline genes
    • Pascual V., Randen I., Thompson K., Sould M., Forre O., Natvig J. B., Capra J. D. The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germline genes. J. Clin. Invest. 86:1990;1320-1328.
    • (1990) J. Clin. Invest. , vol.86 , pp. 1320-1328
    • Pascual, V.1    Randen, I.2    Thompson, K.3    Sould, M.4    Forre, O.5    Natvig, J.B.6    Capra, J.D.7
  • 24
    • 0025763929 scopus 로고
    • Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes
    • Victor K. D., Randen I., Thompson K., Forre O., Natvig J. B., Fu S. M., Capra J. D. Rheumatoid factors isolated from patients with autoimmune disorders are derived from germline genes distinct from those encoding the Wa, Po, and Bla cross-reactive idiotypes. J. Clin. Invest. 87:1991;1603-1613.
    • (1991) J. Clin. Invest. , vol.87 , pp. 1603-1613
    • Victor, K.D.1    Randen, I.2    Thompson, K.3    Forre, O.4    Natvig, J.B.5    Fu, S.M.6    Capra, J.D.7
  • 26
    • 0025284326 scopus 로고
    • Development of a highly sensitive assay, based on the polymerase chain reaction, for rare B-lymphocyte clones in a polyclonal population
    • Brisco M. J., Tan L. W., Orsborn A. M., Morley A. A. Development of a highly sensitive assay, based on the polymerase chain reaction, for rare B-lymphocyte clones in a polyclonal population. Br. J. Haematol. 75:1990;163-167.
    • (1990) Br. J. Haematol. , vol.75 , pp. 163-167
    • Brisco, M.J.1    Tan, L.W.2    Orsborn, A.M.3    Morley, A.A.4
  • 27
    • 0000386558 scopus 로고
    • Southern blotting and hybridization
    • F.M. Ausubel, R. Brent, R.E. Kingston, D.D. Moore, J.G. Seiden, J.A. Smith, & K. Struhl. New York: Green Publishing Associates and Wiley-Interscience
    • Selden R. F. Southern blotting and hybridization. Ausubel F. M., Brent R., Kingston R. E., Moore D. D., Seiden J. G., Smith J. A., Struhl K. Current Protocols in Molecular Biology. 1992;2.9.1-2.9.10 Green Publishing Associates and Wiley-Interscience, New York.
    • (1992) Current Protocols in Molecular Biology , pp. 291-2910
    • Selden, R.F.1
  • 28
    • 0344212391 scopus 로고
    • Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region
    • Matthyssens G., Rabbits T. H. Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region. Proc. Natl. Acad. Sci. USA. 77:1980;6561-6565.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 6561-6565
    • Matthyssens, G.1    Rabbits, T.H.2
  • 31
    • 0026740330 scopus 로고
    • Analysis of immunoglobulin variable region genes from human IgG monoclonal anti-DNA hybridomas
    • Winkler T. H., Fehr H., Kalden J. R. Analysis of immunoglobulin variable region genes from human IgG monoclonal anti-DNA hybridomas. Eur. J. Immunol. 22:1992;1719-1728.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1719-1728
    • Winkler, T.H.1    Fehr, H.2    Kalden, J.R.3
  • 32
    • 0028354751 scopus 로고
    • Serological and genetic characterization of a human monoclonal immunoglobulin G anti-DNA idiotype
    • Ehrenstein M., Longhurst C. M., Latchman D. S., Isenberg D. A. Serological and genetic characterization of a human monoclonal immunoglobulin G anti-DNA idiotype. J. Clin. Invest. 93:1994;1787-1797.
    • (1994) J. Clin. Invest. , vol.93 , pp. 1787-1797
    • Ehrenstein, M.1    Longhurst, C.M.2    Latchman, D.S.3    Isenberg, D.A.4
  • 33
    • 0029153488 scopus 로고
    • Anti-DNA and anti-platelet specificities of SLE-derived autoantibodies: Evidence for CDR2H mutations and CDR3H motifs
    • Rioux J. D., Zdarsky E., Newkirk M. M., Rauch J. Anti-DNA and anti-platelet specificities of SLE-derived autoantibodies: Evidence for CDR2H mutations and CDR3H motifs. Mol. Immunol. 32:1995;683-696.
    • (1995) Mol. Immunol. , vol.32 , pp. 683-696
    • Rioux, J.D.1    Zdarsky, E.2    Newkirk, M.M.3    Rauch, J.4
  • 34
    • 0019846077 scopus 로고
    • Structure of human immunoglobulin mu locus: Characterization of embryonic and rearranged J and D genes
    • Ravetch J. V., Siebenlist U., Korsmeyer S., Waldmann T., Leder P. Structure of human immunoglobulin mu locus: Characterization of embryonic and rearranged J and D genes. Cell. 27:1981;583-591.
    • (1981) Cell , vol.27 , pp. 583-591
    • Ravetch, J.V.1    Siebenlist, U.2    Korsmeyer, S.3    Waldmann, T.4    Leder, P.5
  • 35
    • 0024493018 scopus 로고
    • Characterization of four homologous L chain variable region genes that are related to 6B6.6 idiotype positive human rheumatoid factor L chains
    • Liu M.-F., Robbins D. L., Crowley J. J., Sinha S., Kozin F., Kipps T. J., Carson D. A., Chen P. P. Characterization of four homologous L chain variable region genes that are related to 6B6.6 idiotype positive human rheumatoid factor L chains. J. Immunol. 142:1989;688-694.
    • (1989) J. Immunol. , vol.142 , pp. 688-694
    • Liu, M.-F.1    Robbins, D.L.2    Crowley, J.J.3    Sinha, S.4    Kozin, F.5    Kipps, T.J.6    Carson, D.A.7    Chen, P.P.8
  • 36
    • 0029091016 scopus 로고
    • Structural restriction in the heavy chain CDR3 of human rheumatoid factors
    • Borretzen M., Randen I., Natvig J. B., Thompson K. M. Structural restriction in the heavy chain CDR3 of human rheumatoid factors. J. Immunol. 155:1995;3630-3637.
    • (1995) J. Immunol. , vol.155 , pp. 3630-3637
    • Borretzen, M.1    Randen, I.2    Natvig, J.B.3    Thompson, K.M.4
  • 38
    • 0024238607 scopus 로고
    • Probing the normal and autoimmune B cell repertoire with Epstein-Barr virus. Frequency of B cells producing monoreactive high affinity autoantibodies in patients with Hashimoto's disease and systemic lupus erythematosus
    • Nakamura M., Burastero S. E., Ueki U., Larrick J. K., Notkins A. L., Casali P. Probing the normal and autoimmune B cell repertoire with Epstein-Barr virus. Frequency of B cells producing monoreactive high affinity autoantibodies in patients with Hashimoto's disease and systemic lupus erythematosus. J. Immunol. 141:1988;4165-4172.
    • (1988) J. Immunol. , vol.141 , pp. 4165-4172
    • Nakamura, M.1    Burastero, S.E.2    Ueki, U.3    Larrick, J.K.4    Notkins, A.L.5    Casali, P.6
  • 39
    • 0029061664 scopus 로고
    • Heavy chain variable region, light chain variable region, and heavy chain CDR3 influences on the mono- and polyreactivity and on the affinity of human monoclonal rheumatoid factors
    • Crouzier R., Martin T., Pasquali J.-L. Heavy chain variable region, light chain variable region, and heavy chain CDR3 influences on the mono- and polyreactivity and on the affinity of human monoclonal rheumatoid factors. J. Immunol. 154:1995;4526-4535.
    • (1995) J. Immunol. , vol.154 , pp. 4526-4535
    • Crouzier, R.1    Martin, T.2    Pasquali, J.-L.3
  • 40
    • 0025978752 scopus 로고
    • Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus
    • van Es J. H., Gmelig Meyling F. H. J., van de Akker W. R. M., Aanstoot H., Derksen R. H. W. M., Logtenberg T. Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus. J. Exp. Med. 173:1991;461-470.
    • (1991) J. Exp. Med. , vol.173 , pp. 461-470
    • Van Es, J.H.1    Gmelig Meyling, F.H.J.2    Van De Akker, W.R.M.3    Aanstoot, H.4    Derksen, R.H.W.M.5    Logtenberg, T.6
  • 41
    • 0029030661 scopus 로고
    • Preferential recognition of specific DNA motifs by anti-double-stranded DNA autoantibodies
    • Herrmann M., Winkler T. H., Holger F., Kalden J. R. Preferential recognition of specific DNA motifs by anti-double-stranded DNA autoantibodies. Eur. J. Immunol. 25:1995;1897-1904.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1897-1904
    • Herrmann, M.1    Winkler, T.H.2    Holger, F.3    Kalden, J.R.4


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