Identification and characterization of aarF, a locus required for production of ubiquinone in Providencia stuartii and Escherichia coli and for expression of 2'-N-acetyltransferase in P. stuartii

Journal of Bacteriology

Volumn 180, Issue 1, 1998, Pages 128-135

  Macinga, David R ^a   Cook, Gregory M ^c   Poole, Robert K ^c   Rather, Philip N ^a,b,d  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d Infectious Diseases Section 1110W   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; BACTERIAL ENZYME; PEPTIDOGLYCAN; UBIQUINONE;

ACETYLATION; ARTICLE; ENZYME ACTIVITY; ENZYME INDUCTION; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENE LOCUS; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROVIDENCIA STUARTII; SEQUENCE HOMOLOGY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; PROKARYOTA; PROVIDENCIA STUARTII;

EID: 0031983781     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.180.1.128-135.1998     Document Type: Article

References (39)

1. Bryan, L. E., and H. M. V. D. Elzen. 1976. Streptomycin accumulation in susceptible and resistant strains of Escherichia coli and Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 9:928-938.
2. Bryan, L. E., and S. Kwan. 1981. Aminoglycoside-resistant mutants of Pseudomonas aeruginosa deficient in cytochrome d, nitrate reductase, and aerobic transport. Antimicrob. Agents Chemother. 19:958-964.
3. Bryan, L. E., and S. Kwan. 1983. Roles of ribosomal binding, membrane potential, and electron transport in bacterial uptake of streptomycin and gentamicin. Antimicrob. Agents Chemother. 23:835-845.
4. Bryan, L. E. and H. M. van den Elzen. 1977. Effects of membrane energy mutations and cations on streptomycin and gentamicin accumulation by bacteria: a model tor entry of streptomycin and gentamicin in susceptible and resistant bacteria. Antimicrob. Agents Chemother. 12:163-177.
5. Campbell, B. D., and R. J. Kadner. 1980. Relation of aerobiosis and ionic strength to the uptake of dihydrostreptomycin in Escherichia coli. Biochim. Biophys. Acta 593:1-10.
6. Chang, A. C. Y., and S. N. Cohen. 1978. Construction and characterization of amplifiable DNA cloning vehicles derived from the p15A cryptic miniplasmid. J. Bacteriol. 134:1141-1156.
7. Chevereau, M., P. J. L. Daniel, J. Davies, and F. LeGoffic. 1974. Aminoglycoside resistance in bacteria mediated by gentamicin acetyltransferase II, an enzyme modifying the 2′-amino group of aminoglycoside antibiotics. Biochemistry 13:1141-1156.
8. Clarke, A. J. 1993. Extent of peptidoglycan O acetylation in the tribe Proteeae. J. Bacteriol. 175:4550-4553.
9. Clarke, A. J., and C. Dupont. 1991. O-Acetylated peptidoglycan: its occurrence, pathobiological significance, and biosynthesis. Can. J. Microbiol. 38: 85-91.
10. Collins, M. D. 1985. Analysis of isoprenoid quinones. Methods Microbiol. 18:329-366.
11. Cox, G. B., and J. A. Downie. 1979. Isolation and characterization of mutants Bof Escherichia coli K-12 affected in oxidative phosphorylation or quinone biosynthesis. Methods Enzymol. 56:106-117.
12. Cox, C. B., I. G. Young, L. M. McCann, and F. Gibson. 1969. Biosynthesis of ubiquinone in Escherichia coli K-12: location of genes affecting the metabolism of 3-octaprenyl-4-hydroxybenzoic acid and 2-octaprenylphenol. J. Bacteriol. 99:450-458.
13. Damper, P. D., and W. Epstein. 1981. Role of the membrane potential in bacterial resistance to aminoglycoside antibiotics. Antimicrob. Agents Chemother. 20:803-808.
14. Daniels, D. L., G. Plunkett, V. Burland, and F. R. Blattner. 1992. Analysis of the Escheriehia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes. Science 257:771-777.
15. De Lorenzo, V., M. Herrero, U. Jakubzic, and K. Timmis. 1990. Mini-Tn5 derivatives for insertion mutagenesis, promoter probing, and chromosomal insertion of cloned DNA in gram-negative Eubacteria. J. Bacteriol. 172: 6568-6572.
16. Dupont, C., and A. J. Clarke. 1991. Dependence of lysozyme-catalysed solubilization of Proteus mirabilis peptidoglycan on the extent of O-acetylation. Eur. J. Biochem. 195:763-769.
17. Eisenberg, E. S., L. J. Mandel, H. R. Kaback, and M. H. Miller. 1984. Quantitative association between electrical potential across the cytoplasmic membrane and early gentamicin uptake and killing in Staphylococcus aureus. J. Bacteriol. 157:863-867.
18. Gallegus, M. T., C. Michan, and J. L. Ramos. 1993. The XylS/AraC family of regulators. Nucleic Acids Res. 21:807-810.
19. Gilman, S., and V. Saunders. 1986. Accumulation of gentamicin by Staphylococcus aureus: the role of the transmembrane electrical potential. J. Antimicrob. Chemother. 17:37-44.
20. Guyer, M. S., R. R. Reed, J. A. Steitz, and K. B. Low. 1980. Identification of a sex-factor-affinity site in E. coli as γδ. Cold Spring Harbor Symp. Quant. Biol. 18:75-93.
21. Higgins, D. G;, A. J. Bleasby, and R. Fuchs. 1992. CLUSTAL V: improved software for multiple sequence alignment. Comput. Appl. Biosci. 8:189-191.
22. Kaniga, K., I. Delor, and G. Cornells. 1991. A Wide-host-range suicide vector for improving reverse genetics in Gram-negative bacteria: inactivation of the blaA gene of Yersinia enterocolitica. Gene 109:137-141.
23. Lee, P. T., A. Y. Hsu, H. T. Ha, and C. F. Clarke. 1997. A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene. J. Baeteriol. 179:1748-1754.
24. Macinga, D. R., M. M. Parjocic, and P. N. Rather. 1995. Identification and analysis of aarP, a transcriptional activator of the 2′-N-acetyltransferase in Providencia stuartii. J. Baeteriol. 177:3407-3413.
25. Macinga, D. R., and P. N. Rather. 1996. aarD, a Providencia stuartii homologue of cydD: role in 2′-N-acetyltransferase expression, cell morphology and growth in the presence of an extracellular factor. Mol. Microbiol. 19:511-520.
26. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
27. Miller, M. H., S. C. Edberg, L. J. Mandel, C. F. Behar, and N. H. Steigbigel. 1980. Gentamicin uptake in wild-type and aminoglycoside-resistant small colony mutants of Staphylococcus aureus. Antimicrob. Agents Chemother. 18:722-729.
28. Miller, V. H., and J. J. Mekalanos. 1988. A novel suicide vector and its use in construction of insertion mutations: osmoregulation of outer membrane proteins and virulence determinants in Vibrio choleras requires toxR. J. Bacteriol. 170:2575-2583.
29. Payie, K. G., P. N. Rather, and A. J. Clarke. 1995. Contribution of gentamicin 2′-N-acetyltransferase to the O acetylation of peptidoglycan in Providencia stuartii. J. Bacteriol. 177:4303-4310.
30. Poole, R. K., L. Hatch, M. W. J. Cleeter, F. Gibson, G. B. Cox, and G. Wu. 1993. Cycochrome bd biosynthesis in Escherichia coli: the sequences of the cydC and cydD genes suggest that they encode the components of an ABC membrane transporter. Mol. Microbiol. 10:421-430.
31. Poole, R. K., H. D. Williams, J. A. Downie, and F. Gibson. 1989. Mutations affecting the cytochrome d-containing oxidase complex of Escherichia coli K-12: identification and mapping of a fourth locus, cydD. J. Gen. Microbiol. 135:1865-1874.
32. Rather, P. N. Unpublished results.
33. Rather, P. N., and E. Orosz. 1994. Characterization of aarA, a pleiotropic negative regulator of the 2′-N-acetyltransferase in Providencia stuartii. J. Bacteriol. 176:5140-5144.
34. Rather, P. N., E. Orosz, K. J. Shaw, R. Hare, and G. H. Miller. 1993. Characterization and transcriptional regulation of the 2′-N-acetyltransferase gene from Providencia stuanii. J. Bacteriol. 175:6492-6498.
35. Rather, P. N., K. A. Solinsky, M. R. Paradise, and M. M. Parojcic. 1997. aarC, an essential gene involved in density-dependent regulation of the 2′-N-acetyltransferase in Providencia stuartii. J. Bacteriol. 179:2267-2273.
36. Silhavy, T. J. 1984. Experiments with gene fusions. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
37. Wu, G., H. U. Williams, F. Gibson, and R. K. Poole. 1993. Mutants of Escherichia coli affected in respiration: the cloning and nucleotide sequence of ubiA, encoding the membrane-bound p-hydroxybenzoate:octaprenyltransferase. J. Gen. Microbiol. 139:1795-1805.
38. Yamaguchi, M., and S. Mitsuhashi. 1974. A 2′-N-acetylating enzyme of aminoglycosides. J. Antibiot. 27:507-515.
39. Young, I. G., L. M. McCann, P. Stroobant, and F. Gibson. 1971. Characterization and genetic analysis of mutant strains of Escherichia K-12 accumulating the ubiquinone precursors 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone. J. Bacteriol. 105: 769-778.