Stable low-rate midazolam self-injection with concurrent physical dependence under conditions of long-term continuous availability in baboons

Psychopharmacology

Volumn 135, Issue 1, 1998, Pages 70-81

  Weerts, Elise M ^a   Kaminski, Barbara J ^a   Griffiths, Roland R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anxiolytics; Baboons; Benzodiazepines; Drug abuse; Feeding; Flumazenil; Midazolam; Physical dependence; Reinforcement; Self administration; Withdrawal

Indexed keywords

BENZODIAZEPINE DERIVATIVE; FLUMAZENIL; MIDAZOLAM;

ANIMAL EXPERIMENT; ARTICLE; BABOON; CONTROLLED STUDY; DRUG ABUSE; DRUG DEPENDENCE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; REINFORCEMENT; SELF INJECTION; WITHDRAWAL SYNDROME;

ANIMALS; ANTI-ANXIETY AGENTS; FEEDING BEHAVIOR; FLUMAZENIL; MALE; MIDAZOLAM; PAPIO; SELF ADMINISTRATION; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS;

EID: 0031983750     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050487     Document Type: Article

References (56)

1. Ator NA, Griffiths RR (1992) Oral self-administration of triazolam, diazepam and ethanol in the baboon: drug reinforcement and benzodiazepine physical dependence. Psychopharmacology 108: 301-312
2. Ator NA, Griffiths RR (1993) Differential sensitivity to midazolam discriminative-stimulus effects following self-administered versus response-independent midazolam. Psychopharmacology 110: 1-4
3. Balster RL, Woolverton WL (1982) Intravenous buspirone self-administration in rhesus monkeys. J Clin Psychiatry 43[12 Sect 2]: 34-37
4. Bergman J, Johanson CE (1985) The reinforcing properties of diazepam under several conditions in the rhesus monkey. Psychopharmacology 86: 108-113
5. Boisse NR, Quaglietta N, Samoriski GM, Guarino JJ (1990) Tolerance and physical dependence to a short-acting benzodiazepine, midazolam. J Pharmacol Exp Ther 252: 1125-1133
6. Cooper SJ, Francis RL (1979) Feeding parameters with two food textures after chlordiazepoxide administration, alone or in combination with d-amphetamine or fenfluramine. Psychopharmacology 62: 253-259
7. Cooper SJ, Moores WR (1985) Chlordiazepoxide-induced hyperphagia in non-food-deprived rats: effects of Ro15-1788. CGS 8215 and ZK 93426. Eur J Pharmacol 112: 39-45
8. de la Garza R, Johanson CE (1987) The effects of food deprivation on the self-administration of psychoactive drugs. Drug Alcohol Depend 19: 17-27
9. Deneau G, Yanagita T, Seevers MH (1969) Self-administration of psychoactive substances by the monkey - a measure of psychological dependence. Psychopharmacologia 16: 30-48
10. Dougherty J, Pickens R (1976) Pharmacokinetics of IV cocaine self-injection. In: Mulé SJ (ed) Cocaine: chemical, biological, clinical, social and treatment aspects. CRC Press, Cleveland, Ohio, pp 105-120
11. Ferster CB, Skinner BF (1957) Schedules of reinforcement. Prentice-Hall, Englewood Cliffs, NJ
12. Finlay JM, Szostak C, Fibiger HC (1989) Further characterization of intravenous self-administration of midazolam in the rat. Behav Pharmacol 1: 13-23
13. Foltin RW, Fischman MW, Byrne MF (1989) Food intake in baboons: effects of diazepam. Psychopharmacology 97: 443-447
14. Fridman EP, Popova VN (1988) Species of the genus Papio (Cercopithecidae) as subjects of biomedical research: I. Biological basis of experiments in baboons. J Med Primatol 17: 291-307
15. Goudie AJ, Harrison AA, Leathley MJ (1993) Evidence for a dissociation between benzodiazepine withdrawal signs. NeuroReport 4: 295-298
16. Grant KA, Johanson CE (1987) Diazepam self-administration and resistance to extinction. Pharmacol Biochem Behav 28: 81-86
17. Griffiths RR (1995) Commentary on review by Woods and Winger. Benzodiazepine: long-term use among patients is a concern and abuse among polydrug abusers is not trivial. Psychopharmacology 118: 116-117
18. Griffiths RR, Mumford GK (1995) Caffeine - a drug of abuse? In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven Press, New York, pp 1699-1713
19. Griffiths RR, Weerts EM (1997) Benzodiazepine self-administration in humans and laboratory animals - implications for problems of long-term use and abuse. Psychopharmacology 134: 1-37
20. Griffiths RR, Winger G, Brady JV, Snell JD (1976) Comparison of behavior maintained by infusions of eight phenylethylamines in baboons. Psychopharmacology 50: 251-258
21. Griffiths RR, Bigelow GE, Henningfield JE (1980) Similarities in animals and human drug-taking behavior. In: Mello NK (ed) Advances in substance abuse, vol 1. JAI Press, Greenwich, Conn, pp 1-90
22. Griffiths RR, Lukas SE, Bradford LD, Brady JV, Snell J (1981) Self-injection of barbiturates and benzodiazepines in baboons. Psychopharmacology 75: 101-109
23. Griffiths RR, Lamb RJ, Ator NA, Roache JD, Brady JV (1985) Relative abuse liability of triazolam: experimental assessment in animals and humans. Neurosci Biobehav Rev 9: 133-151
24. Griffiths RR, Lamb RJ, Sannerud CA, Ator NA, Brady JV (1991) Self-injection of barbiturates, benzodiazepines and other sedative-anxiolytics in baboons. Psychopharmacology 103: 154-161
25. Griffiths RR, Sannerud CA, Ator NA, Brady JV (1992) Zolpidem behavioral pharmacology in baboons: self-injection, discrimination, tolerance and withdrawal. J Pharmacol Exp Ther 260: 1199-1208
26. Grimm VE, Jancourt A (1983) The effects of chronic diazepam treatment on body weight and food intake in rats. Int J Neurosci 318: 127-136
27. Hackett D, Hall JM (1977) Reinforcing properties of intravenous diazepam in rhesus monkeys (Macaca mulatta) with a history of codeine self-administration. In: Dincon WAM (ed) Clinical Toxicological Proceedings of the 18th Meeting of the European Society of Toxicology. Excerpta Medica, Amsterdam, pp 308-310
28. Hallström C (1993) Benzodiazepine dependence. Oxford University Press, Oxford
29. Hodge's HM, Green SE, Crewes H, Mathers I (1981) Effects of chronic chlordiazepoxide treatment on novel and familiar food preference in rats. Psychopharmacology 75: 311-314
30. Johanson CE, Balster RL, Bonese K (1976) Self-administration of psychomotor stimulant drugs: the effects of unlimited access. Pharmacol Biochem Behav 4: 45-51
31. Kubota A, Kuwahara A, Hakkei M, Nakamura K (1986) Drug dependence test on a new anesthesia inducer, midazolam. Folia Pharmacol Japon 88: 125-158
32. Lamb RJ, Griffiths RR (1987) Effects of Ro 15-1788 and CGS 8216 in diazepam-dependent baboons. Eur J Pharmacol 143: 205-212
33. Lukas SE, Griffiths RR (1982) Precipitated withdrawal by a benzodiazepine receptor antagonist (Ro15-1788) after 7 days of diazepam. Science 217: 1161-1163
34. Lukas SE, Griffiths RR, Bradford DL, Brady JV, Daley L (1982) A tethering system for intravenous and intragastric drug administration in the baboon. Pharmacol Biochem Behav 17: 823-829
35. Martin JR, Moreau J, Jenck E (1995) Precipitated withdrawal in squirrel monkeys after repeated daily administration of alprazolam, diazepam, flunitrazepam or oxazepam. Psychopharmacology 118: 273-279
36. Martin WR, Sloan JW, Wala E (1990) Precipitated abstinence in orally dosed benzodiazepine-dependent dogs. J Pharmacol Exp Ther, 255: 744-755
37. Martin WR, Sloan JW, Wala EP (1993) Precipitated abstinence in the diazepam-dependent rat. Pharmacol Biochem Behav 46: 683-688
38. Miczek KA (1982) Ethological analysis of drug action on aggression, defense and defeat. In: Speigelstein MY, Levy A (eds) Behavioral models and analysis of drug action. Elsevier, Amsterdam, pp 225-239
39. Nader MA, Winger G, Woods JH, Woolverton WL (1991) Discriminative and reinforcing effects of brotizolam in rhesus monkeys. Psychopharmacology 103: 166-171
40. Naruse T (1994) Effects of repeated intravenous administration of diazepam on food intake in rats. Fundam Clin Pharmacol 8: 379-384
41. Naruse T, Asami T (1987) Intravenous self-administration of diazepam in rats. Eur J Pharmacol 135: 365-373
42. Pickens RW, Thompson T (1968) Cocaine-reinforced behavior in rats: effects of reinforcement magnitude and fixed-ratio size. J Pharmacol Exp Ther 161: 122-129
43. Pilotto R, Singer G, Overstreet D (1984) Self-injection of diazepam in naive rats: effects of dose, schedule and blockade of different receptors. Psychopharmacology 84: 174-177
44. Randall LO, Schallek W, Heise GA, Keith EF, Bagdon RE (1960) The psychosedative properties of methaminodiazepoxide. J Pharmacol Clin Ther 129: 163-171
45. Sannerud CA, Allen M, Cook JM, Griffiths RR (1991) Behavioral effects of benzodiazepine ligands in non-dependent, diazepam dependent and diazepam withdrawn baboons. Eur J Pharmacol 202: 159-169
46. Schuster CR Jr (1970) Psychological approaches to opiate dependence and self-administration by laboratory animals. Fed Proc 29: 2-5
47. Sloan JW, Martin WR, Wala EP (1990) Dependence producing properties of alprazolam in the dog. Pharmacol Biochem Behav 35: 651-657
48. Sloan JW, Martin WR, Wala EP (1993) Effect of the chronic dose of diazepam on the intensity and characteristics of the precipitated abstinence syndrome in the dog. J Pharmacol Clin Ther 265: 1152-1162
49. Szostak C, Finlay JM, Fibiger HC (1987) Intravenous self-administration of the short-acting benzodiazepine midazolam in the rat. Neuropharmacology 26: 1673-1676
50. Weerts EM, Tornatzky W, Miczek KA (1993) "Anxiolytic" and "anxiogenic" benzodiazepines and beta-carbolines: effects on aggressive and social behavior in rats and squirrel monkeys. Psychopharmacology 110: 451-459
51. Wilson MC, Hitomi M, Schuster CR (1971) Psychomotor stimulant self administration as a function of dosage per injection in the rhesus monkey. Psychopharmacologia 22: 271-281
52. Winger G, Stitzer ML, Woods JH (1975) Barbiturate-reinforced responding in rhesus monkeys: comparisons of drugs with different durations of action. J Pharmacol Exp Ther 195: 505-514
53. Winger G, Woods JH, Patrick GA, Powell LJ, Harris LS, Nader MA, Woolverton WL (1992) Progress report from the testing program for stimulant and depressant drugs (1991). In: Harris LS (ed) Problems of drug dependence, 1991. NIDA Research Monograph No. 119, DHHS Publication No (ADM) 92-1888. US Government Printing Office, Washinaton, DC, pp 625-639
54. Woods JH, Kutz JL, Winger G (1987) Abuse liability of benzodiazepines. Pharmacol Rev 39: 251-419
55. Woods JH, Katz JL, Winger G (1992) Benzodiazepines: use, abuse, and consequences. Pharmacol Rev 44: 151-347
56. Yokel RA, Pickens R (1974) Drug level of d- and l-amphetamine during intravenous self-administration. Psychopharmacologia 34:255-264