Absence of immunogenicity of diaspirin cross-linked hemoglobin in humans

Blood

Volumn 91, Issue 2, 1998, Pages 710-716

  Patel, Mehul J ^a   Webb, Edwin J ^b   Shelbourn, Tina E ^b   Mattia Goldberg, Cynthia ^b   George, Andrew J T ^b   Zhang, Feng ^b   Moore, Edwin G ^b   Nelson, Deanna J ^b  

^a BAXTER HEALTHCARE CORPORATION   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD SUBSTITUTE; DIASPIRIN CROSSLINKED HEMOGLOBIN; HEMOGLOBIN; UNCLASSIFIED DRUG;

ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CROSS LINKING; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNE RESPONSE; IMMUNOBLOTTING; IMMUNOGENICITY; MAJOR CLINICAL STUDY; OPTICAL DENSITY; PRIORITY JOURNAL;

EID: 0031983695     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.2.710.710_710_716     Document Type: Article

References (21)

1. Amberson WR: Blood substitutes. Biol Rev 12:48, 1937
2. Moffat AS: Three li'l pigs and the hunt for blood substitutes. Science 253:32, 1991
3. O'Donnell JK, Martin MJ, Logan JS, Kumar R: Production of human hemoglobin in transgenic swine: An approach to a blood substitute. Cancer Detect Prev 17:307, 1993
4. Vandegriff KD, Medina F, Marini M, Winslow RM: Equilibrium oxygen binding to human hemoglobin crosslinked between the α chains by bis(3,5-dibromosalicyl) fumarate. J Biol Chem 264:17824, 1989
5. Roth RI, Levin J, Chapman KW, Scmeizl M, Rickles FR: Production of modified crosslinked cell-free hemoglobin for human use: The role of quantitative determination of endotoxin contamination. Transfusion 33:919, 1993
6. Chatterjee R, Welty EV, Walder RY, Pruitt ST, Rogers PH, Arnone A, Walders JA: Isolation and characterization of a new hemoglobin derivative crosslinked between the α chains. J Biol Chem 261:9929, 1986
7. Snyder SR, Welty EV, Walder RY, Williams LA, Walder JA: HbXL99a, a hemoglobin derivative that is crosslinked between the α subunits is useful as a blood substitute. Proc Natl Acad Sci USA 84:7280, 1987
8. Farmer MC, Pryzbelski RJ, McKenzie JE, Burhop KE: Preclinical data and clinical trial with diaspirin crosslinked hemoglobin, in Tsuchida E (ed): Artificial Red Cells. New York, NY, Wiley, 1995, p 177
9. Cole DJ, Schell RM, Drummond JC, Pryzbelski RJ, Marcantonio S: Focal cerebral ischemia in rats: Effect of hemodilution with α-α crosslinked hemoglobin on brain injury and edema. Can J Neurol Sci 20:30, 1993
10. Konrad M: Immunogenicity of proteins administered to humans for therapeutic purposes. Trends Biotechnol 7:175, 1989
11. Cochin A, Das Gupta TK, De Woskin, R, Moss, GS: Hemoglobin II. Immunogenic properties of stroma versus stroma-free hemoglobin solution. J Surg Oncol 4:19, 1974
12. Estep TN, Gonder J, Bornstein I, Aono F: Immunogenicity of diaspirin cross-linked human hemoglobin solutions. Biomat Art Cells Immob Biotech 20:603, 1992
13. Harlow E, Lane D: Antibodies: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1988
14. Cush R, Cronin JM, Stewart WJ, Maule CH, Molloy J, Goddard NJ: The resonant mirror: A novel optical biosensor for direct sensing of biomolecular interactions. Part I: Principles of operation and associated instrumentation. Biosens Bioelectron 8:347, 1993
15. Buckle BE, Davies RJ, Kinning T, Yeung D, Edwards PR, Pollard-Knight D, Lowe CR: The resonant mirror: A novel optical biosensor for direct sensing of biomolecular interactions. Part II: Applications. Biosens Bioelectron 8:355, 1993
16. George AJT, French RR, Glennie MJ: Measurement of kinetic binding constants of a panel of anti-saporin antibodies using a resonant mirror biosensor. J Immunol Methods 183:51, 1995
17. de Savigny D, Voller A: The communication of ELISA data from laboratory to clinician. J Immunoassay 1:105, 1980
18. Patel MJ, Yu Z, Friso G, Lo-Tseng T, Webb EJ, Moore EG, Burlingame AL: Structural characterization of a hemoglobin based blood substitute: Diaspirin crosslinked hemoglobin (DCLHb™). Prot Sci 6:109, 1997 (suppl 1)
19. Shelbourn TE, Moore EG, Patel MJ: Characterization of diaspirin crosslinked hemoglobin (DCLHb™) by spectroscopic techniques. FASEB J 10:A1388, 1996
20. Patel MJ, Webb EJ, Shelbourn TE, Nelson DJ: Diaspirin crosslinked hemoglobin: Biocompatibility studies. Pharm Res 11:S-79, 1994
21. Pryzbelski RJ, Daily EK, Kisicki JC, Mattia-Goldberg C, Bounds MJ, Colburn WA: Phase I study of the safety and pharmacologic effects of diaspirin crosslinked hemoglobin solution. Crit Care Med 24:1993, 1996