Clinical impact and associated costs of Clostridium difficile-associated disease

Journal of Antimicrobial Chemotherapy

Volumn 41, Issue SUPPL. C, 1998, Pages 5-12

  Spencer, Robert C ^a  

^a BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; ENEMA;

BACTERIAL INFECTION; BACTERIUM CARRIER; CLOSTRIDIUM DIFFICILE; DIARRHEA; DISEASE PREDISPOSITION; GASTROSTOMY; HEALTH CARE COST; HOSPITAL INFECTION; HOSPITALIZATION; HUMAN; IMMUNE DEFICIENCY; NASOGASTRIC TUBE; PERISTALSIS; REVIEW; SURGICAL PATIENT;

AGE FACTORS; CLOSTRIDIUM DIFFICILE; CROSS INFECTION; DIARRHEA; ENTEROCOLITIS, PSEUDOMEMBRANOUS; HUMANS; INCIDENCE;

EID: 0031982032     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/41.suppl_3.5     Document Type: Review

References (98)

1. Lyerly, D. M., Krivan, H. C. & Wilkins, T. D. (1988). Clostridium difficile: its disease and toxins. Clinical Microbiology Reviews 1, 1-18.
2. Gerding, D. N. (1989). Disease associated with Clostridium difficile infection. Annals of Internal Medicine 110, 255-7.
3. McFarland, L. V. & Stamm, W. E. (1986). Review of Clostridium difficile-associated diseases. American Journal of Infection Control 14, 99-109.
4. Gerding, D. N., Johnson, S., Peterson, L. R., Mulligan, M. E. & Silva, J. (1995). Clostridium difficile-associated diarrhoea and colitis. Infection Control and Hospital Epidemiology 16, 459-77.
5. Yannelli, B., Gurevich, I., Schoch, P. E. & Cunha, B. A. (1988). Yield of stool cultures, ova and parasite tests, and Clostridium difficile determinations in nosocomial diarrhoeas. American Journal of Infection Control 16, 246-9.
6. Siegel, D. L., Edelstein, P. H. & Nachamkin, I. (1990). Inappropriate testing for diarrheal diseases in the hospital. Journal of the American Medical Association 263, 979-82.
7. Fekety, R., Kim, K.-H., Brown, D., Batts, D. H., Cudmore, M. & Silva, J. (1981). Epidemiology of antibiotic-associated colitis: isolation of Clostridium difficile from the hospital environment. American Journal of Medicine 70, 906-8.
8. McFarland, L. V., Mulligan, M. E., Kwok, R. Y. Y. & Stamm, W. E. (1989). Nosocomial acquisition of Clostridium difficile infection. New England Journal of Medicine 320, 204-10.
9. Johnson, S., Clabots, C. R., Linn, F. V., Olson, M. M., Peterson, L. R. & Gerding, D. N. (1990). Nosocomial Clostridium difficile colonisation and disease. Lancet 336, 97-100.
10. Gerding, D. N., Olson, M. M., Peterson, L. R., Teasley, D. G., Gebhard, R. L., Schwartz, M. L. et al. (1986). Clostridium difficile-associated diarrhea and colitis in adults. A prospective case-controlled epidemiologic study. Archives of Internal Medicine 146, 95-100.
11. Hall, J. C. & O'Toole, E. (1935). Intestinal flora in newborn infants with a description of a new pathogenic anaerobe, Bacillus difficilis. American Journal of Diseases in Childhood 49, 390-402.
12. Bartlett, J. G., Moon, N., Chang, T. W., Taylor, N. & Onderdonk, A. B. (1978). Role of Clostridium difficile in antibiotic-associated pseudomembranous colitis. Gastroenterology 75, 778-82.
13. George, R. H., Symonds, J. M., Dimock, F., Brown, J. D., Arubi, Y., Shinagawa, N. et al. (1978). Identification of Clostridium difficile as a cause of pseudomembranous colitis. British Medical Journal i, 695.
14. George, W. L., Sutter, V. L. & Finegold, S. M. (1978). Toxigenicity and antimicrobial susceptibility of Clostridium difficile, a cause of antimicrobial agent-associated colitis. Current Microbiology 1, 55-8.
15. Larson, H. E., Price, A. B., Honour, P. & Borriello, S. P. (1978). Clostridium difficile and the aetiology of pseudomembranous colitis. Lancet i, 1063-6.
16. Borriello, S. P. (1991). Anaerobic bacteria in diarrhoea and colitis. In Anaerobes in Human Disease (Duerden, B. I. & Drasar, B. S., eds), pp. 351-61. Edward Arnold, London.
17. Tabaqchali, S. & Jumaa, P. (1995). Diagnosis and management of Clostridium difficile infection. British Medical Journal 310, 1375-80.
18. Burke, G. W., Wilson, M. E. & Mehrez, I. O. (1988). Absence of diarrhea in toxic megacolon complicating Clostridium difficile pseudomembranous colitis. American Journal of Gastroenterology 83, 304-7.
19. Bartlett, J. G. (1990). Clostridium difficile: clinical considerations. Reviews of Infectious Diseases 12, Suppl. 2, S243-51.
20. Johnson, S., Homann, S. R., Bettin, K. M., Quick, J. N., Clabots, C. R., Peterson, L. R. et al. (1992). Treatment of asymptomatic Clostridium difficile carriers (fecal excretors) with vancomycin or metronidazole. A randomized, placebo-controlled trial. Annals of Internal Medicine 117, 297-302.
21. Tedesco, F. J., Barton, R. W. & Alpers, D. H. (1974). Clindamycin-associated colitis: a prospective study. Annals of Internal Medicine 81, 429-33.
22. Bartlett, J. G. (1992). Antibiotic-associated diarrhoea. Clinical Infectious Diseases 15, 573-81.
23. Kelly, C. P., Pothoulakis, C. & LaMont, J. T. (1994). Clostridium difficile colitis. New England Journal of Medicine 330, 257-62.
24. Cartmill, T. D. I., Panigrahi, H., Worsley, M. A., McCann, D. C., Nice, C. N. & Keith, E. (1994). Management and control of a large outbreak of diarrhoea due to Clostridium difficile. Journal of Hospital Infection 27, 1-15.
25. Wilcox, M. H. & Spencer, R. C. (1992). Clostridium difficile infection: responses, relapses, and re-infections. Journal of Hospital Infection 22, 85-92.
26. Dodson, A. P. & Borriello, S. P. (1996). Clostridium difficile infection of the gut. Journal of Clinical Pathology 49, 529-32.
27. Whitehead, R. (1985). Muscosal Biopsy of the Gastrointestinal Tract. W. B. Saunders, Philadelphia.
28. Tedesco, F. J., Corless, J. K. & Brownstein, R. E. (1982). Rectal sparing in antibiotic-associated pseudomembranous colitis: a prospective study. Gastroenterology 83, 1259-60.
29. Cone, J. B. & Wetzel, W. (1982). Toxic megacolon secondary to pseudomembranous colitis. Diseases of the Colon and Rectum 25, 478-82.
30. Morris, J. B., Zollinger, R. M. & Stellato, T. A. (1990). Role of surgery in antibiotic-induced pseudomembranous enterocolitis. American Journal of Surgery 160, 535-9.
31. Levett, P. N. (1986). Clostridium difficile in habitats other than the human gastro-intestinal tract. Journal of Infection 12, 253-63.
32. Lofgren, R. P., Tadlock, L. M. & Soltis, R. D. (1984). Acute oligoarthritis associated with Clostridium difficile pseudomembranous colitis. Archives of Internal Medicine 144, 617-9.
33. Gryboski, J. D., Pellerano, R., Young, N. & Edberg, S. (1991). Positive role of Clostridium difficile infection in diarrhoea in infants and children. American Journal of Gastroenterology 86, 685-9.
34. Bolton, R. P., Tait, S. K., Dear, P. R. & Losowsky, M. S. (1984). Asymptomatic neonatal colonisation by Clostridium difficile. Archives of Disease in Childhood 59, 466-72.
35. Borriello, S. P. (1979). Clostridium difficile and its toxin in the gastrointestinal tract in health and disease. Research and Clinical Forums 1, 33-5.
36. Tabaqchali, S., O'Farrell, S., Nash, J. Q. & Wilks, M. (1984). Vaginal carriage and neonatal acquisition of Clostridium difficile. Journal of Medical Microbiology 18, 47-53.
37. Holst, E., Helin, I. & Mardh, P. A. (1981). Recovery of Clostridium difficile from children. Scandinavian Journal of Infectious Diseases 13, 41-5.
38. Larson, H. E., Barclay, F. E., Honour, P. & Hill, I. D. (1982). Epidemiology of Clostridium difficile in infants. Journal of Infectious Diseases 146, 727-33.
39. Bacon, A. E., Fekety, R., Schaberg, D. R. & Faix, R. G. (1988). Epidemiology of Clostridium difficile colonization in newborns: results using a bacteriophage and bacteriocin typing system. Journal of Infectious Diseases 158, 349-54.
40. Viscidi, R., Willey, S. & Bartlett, J. G. (1981). Isolation rates and toxigenic potential of Clostridium difficile isolates from various patient populations. Gastroenterology 81, 5-9.
41. Cooperstock, M., Riegle, L., Woodruff, C. W. & Onderdonk, A. (1983). Influence of age, sex, and diet on asymptomatic colonization of infants with Clostridium difficile. Journal of Clinical Microbiology 17, 830-3.
42. Libby, J. M., Donta, S. T. & Wilkins, T. D. (1983). Clostridium difficile toxin A in infants. Journal of Infectious Diseases 148, 606.
43. Brettle, R. P. & Wallace, E. (1982). Clostridium difficile from stools of normal children. Lancet i, 1193.
44. Borriello, S. P. & Barclay, F. E. (1984). Colonisation resistance to Clostridium difficile infection. Microecology and Therapeutics 14, 75-87.
45. Ellis, M. E., Mandal, B. K., Dunbar, E. M. & Bundell, K. R. (1984). Clostridium difficile and its cytotoxin in infants admitted to hospital with infectious gastroenteritis. British Medical Journal 288, 524-6.
46. Mulligan, M. E. (1988). General epidemiology, potential reservoirs and typing procedures. In Clostridium difficile - its Role in Intestinal Disease (Rolfe, R. D. & Finegold, S. M., Eds), pp. 229-56. Academic Press, London.
47. Stark, P. L., Lee, A. & Parsonage, B. (1982). Colonization of the large bowel by Clostridium difficile in healthy infants: quantitative study. Infection and Immunity 35, 895-9.
48. Svedhem, A., Kaijser, B. & MacDowall, I. (1982). Intestinal occurrence of Campylobacter fetus subspecies jejuni and Clostridium difficile in children in Sweden. European Journal of Clinical Microbiology 1, 29-32.
49. George, W. L. (1988). Antimicrobial agent-associated diarrhoea in adult humans. In Clostridium difficile - its Role in Intestinal Disease (Rolfe, R. D. & Finegold, S. M., Eds), pp. 31-44. Academic Press, London.
50. Tabaqchali, S. & Wilks, M. (1992). Epidemiological aspects of infections caused by Bacteroides fragilis and Clostridium difficile. European Journal of Clinical Microbiology and Infectious Diseases 11, 1049-57.
51. Heard, S. R., O'Farrell, S., Holland, D., Crook, S., Barnett, M. J. & Tabaqchali, S. (1986). The epidemiology of Clostridium difficile infection with use of a typing scheme: nosocomial acquisition and cross-infection among immunocompromised patients. Journal of Infectious Diseases 153, 159-62.
52. Samore, M. H., DeGirolami, P. C., Tlucko, A., Lichtenberg, D. A., Melvin, Z. A. & Karchmer, A. W. (1994). Clostridium difficile colonization and diarrhea at a tertiary care hospital. Clinical Infectious Diseases 18, 181-7.
53. Wu, T. C., McCarthy, V. P. & Gill, V. J. (1983). Isolation rate and toxigenic potential of Clostridium difficile isolates from patients with cystic fibrosis. Journal of Infectious Diseases 148, 176.
54. McFarland, L. V., Surawicz, C. M. & Stamm, W. E. (1990). Risk factors for Clostridium difficile carriage and C. difficile-associated diarrhea in a cohort of hospitalized patients. Journal of Infectious Diseases 162, 678-84.
55. Clabots, C. R., Johnson, S., Olson, M. M., Peterson, L. R. & Gerding D. N. (1992). Acquisition of Clostridium difficile by hospitalised patients: evidence for colonised new admissions as a source of infection. Journal of Infectious Diseases 166, 561-7.
56. Communicable Disease Surveillance Centre. (1998). Clostridium difficile in England and Wales: quarterly report. Communicable Disease Report Weekly 8, 15.
57. Borriello, S. P. & Larson, H. E. (1981). Antibiotic and pseudomembranous colitis. Journal of Antimicrobial Chemotherapy 7, Suppl. A, 53-62.
58. Djuretic, T., Ryan, M. J., Fleming, D. M. & Wall, P. G. (1996). Infectious intestinal disease in elderly people. Communicable Disease Report CDR Review 6, R107-12.
59. Nash, J. Q., Chattopadhyay, B., Honeycombe, J. & Tabaqchali, S. (1982). Clostridium difficile and cytotoxin in routine faecal specimens. Journal of Clinical Pathology 35, 561-5.
60. Treloar, A. J. & Kalra, L. (1987). Mortality and Clostridium difficile diarrhoea in the elderly. Lancet ii, 1279.
61. Simor, A. E., Yake, S. L. & Tsimidis, K. (1993). Infection due to Clostridium difficile among elderly residents of a long-term-care facility. Clinical Infectious Diseases 17, 672-8.
62. Borriello, S. P. (1990). Pathogenesis of Clostridium difficile infection of the gut. Journal of Medical Microbiology 33, 207-15.
63. Viscidi, R., Laughon, B. E., Yolken, R., Bo-Linn, P., Monench, T., Ryder, R. W. et al. (1983). Serum antibody response to toxins A and B of Clostridium difficile. Journal of Infectious Diseases 148, 93-100.
64. Borriello, S. P. & Barclay, F. E. (1986). An in-vitro model of colonisation resistance to Clostridium difficile infection. Journal of Medical Microbiology 21, 299-309.
65. Bender, B. S., Bennett, R. G., Laughon, B. E., Greenough, W. B., Gaydos, C., Sears, S. D. et al. (1986). Is Clostridium difficile endemic in chronic-care facilities? Lancet ii, 11-3.
66. Rudensky, B., Rosner, S., Sonnenblick, M., van Dijk, Y., Shapira, E. & Isaacsohn, M. (1993). The prevalence and nosocomial acquisition of Clostridium difficile in elderly hospitalized patients. Postgraduate Medical Journal 69, 45-7.
67. George, W. L., Sutter, V. L., Goldstein, E. J. C., Ludwig, S. L. & Finegold, S. M. (1978). Aetiology of antimicrobial-agent associated colitis. Lancet i, 802-3.
68. Aronsson, B., Barany, P., Nord, C. E., Nystrom, B. & Stenvinkel, P. (1987). Clostridium difficile-associated diarrhoea in uremic patients. European Journal of Clinical Microbiology 6, 352-6.
69. Bartlett, J. G. & Gorbach, S. L. (1977). Pseudomembranous enterocolitis (antibiotic-related colitis). Advances in Internal Medicine 22, 455-76.
70. Dosik, G. M., Luna, M., Valdivieso, M., McCredie, K. B., Gehan, E. A., Gil-Extremera, B. et al. (1979). Necrotizing colitis in patients with cancer. American Journal of Medicine 67, 646-56.
71. Moskowitz, M. & Bartlett, J. G. (1981). Recurrent pseudomembranous colitis unassociated with prior antibiotic therapy. Archives of Internal Medicine 141, 663-4.
72. Prendergast, T. M., Marini, C. P., D'Angelo, A. J., Sher, M. E. & Cohen, J. R. (1994). Surgical patients with pseudomembranous colitis: factors affecting prognosis. Surgery 116, 768-75.
73. Rosenberg, J. M., Walker, M., Welch, J. P. & Mullany, L. (1984). Clostridium difficile colitis in surgical patients. American Journal of Surgery 147, 486-91.
74. Fulton, J. D. & Fallon, R. J. (1987). Is Clostridium difficile endemic in chronic-care facilities. Lancet ii, 393-4.
75. Bennett, R. G., Laughton, B. L., Greenough, W. B. & Bartlett, J. G. (1989). Clostridium difficile in elderly patients. Age and Ageing 18, 354-5.
76. Poxton, I. R., Aronsson, B., Mollby, R., Nord, C. E. & Collee, J. G. (1984). Immunochemical fingerprinting of Clostridium difficile strains isolated from an outbreak of antibiotic-associated colitis and diarrhoea. Journal of Medical Microbiology 17, 317-24.
77. Mogg, G. A. G., Keighley, M. R. B., Burdon, D. W., Alexander-Williams, J., Youngs, D., Johnson, M. et al. (1979). Antibiotic-associated colitis - a review of 66 cases. British Journal of Surgery 66, 738-42.
78. Thibault, A., Miller, M. A. & Gaese, C. (1991). Risk factors for the development of Clostridium difficile-associated diarrhea during a hospital outbreak. Infection Control and Hospital Epidemiology 12, 345-8.
79. Rampling, A., Warren, R. E., Bevan, P. C., Hoggarth, C. E., Swirsky, D. & Hayhoe, F. G. (1985). Clostridium difficile in haematological malignancy. Journal of Clinical Pathology 38, 445-51.
80. Heard, S. R., Wren, B., Barnett, M. J., Thomas, J. M. & Tabaqchali, S. (1987). Clostridium difficile infection in patients with haematological malignant disease. Risk factors, faecal toxins and pathogenic strains. Epidemiology and Infection 100, 63-72.
81. Delmee, M., Vandercam, B., Avescani, V. & Michaux, J. L. (1987). Epidemiology and prevention of Clostridium difficile infection in a leukaemia unit. European Journal of Clinical Microbiology 6, 623-7.
82. Kamthan, A. G., Bruckner, H. W., Hirschman, S. Z. & Agus, S. G. (1992). Clostridium difficile diarrhea induced by cancer chemotherapy. Archives of Internal Medicine 152, 1715-7.
83. Anand, A. & Glatt, A. E. (1993). Clostridium difficile infection associated with antineoplastic chemotherapy: a review. Clinical Infectious Diseases 17, 109-13.
84. Cudmore, M. A., Silva, J., Fekety, R., Liepman, M. K. & Kim, K.-H. (1982). Clostridium difficile colitis associated with cancer chemotherapy. Archives of Internal Medicine 142, 333-5.
85. Silva, J., Fekety, R., Werk, C., Ebright, J., Cudmore, M., Batts, D. et al. (1984). Inciting and etiologic agents of colitis. Reviews of Infectious Diseases 6, Suppl. 1, 214-21.
86. Fainstein, V., Bodey, G. P. & Fekety, R. (1981). Relapsing pseudomembranous colitis associated with cancer chemotherapy. Journal of Infectious Diseases 143, 865.
87. Miller, S. D. & Koornhof, H. J. (1984). Clostridium difficile colitis associated with the use of antineoplastic agents. European Journal of Clinical Microbiology 3, 10-3.
88. Talbot, R. W., Walker, R. C. & Beart, R. W. (1986). Changing epidemiology, diagnosis, and treatment of Clostridium difficile toxin-associated colitis. British Journal of Surgery 73, 457-60.
89. Hutin, Y., Molina, J. M., Casin, I., Daix, V., Sednaoui, P., Welker, Y. et al. (1993). Risk factors for Clostridium difficile-associated diarrhoea in HIV-infected patients. AIDS 7, 1441-7.
90. McBride, M. O., Horner, P. J., Coker, R. J. & Harris, J. R. (1994). Clostridium difficile-associated diarrhoea in HIV-infected patients. AIDS 8, 557-8.
91. Barbut, F., Mario, N., Meyohas, M. C., Binet, D., Frottier, J., Petit, J. C. et al. (1994). Investigation of a nosocomial outbreak of Clostridium difficile-associated diarrhoea among AIDS patients by random amplified polymorphic DNA (RAPD) assay. Journal of Hospital Infection 26, 181-9.
92. Cappell, M. S. & Philogene, C. (1993). Clostridium difficile infection is a treatable cause of diarrhea in patients with advanced human immunodeficiency virus infection: a study of seven consecutive patients admitted from 1986 to 1992 to a university teaching hospital. American Journal of Gastroenterology 88, 891-7.
93. Tumbarello, M., Tacconelli, E., Leone, F., Cauda, R. & Ortona, L. (1995). Clostridium difficile-associated diarrhoea in patients with human immunodeficiency virus infection: a case-control study. European Journal of Gastroenterology and Hepatology 7, 259-63.
94. Cozart, J. C., Kalangi, S. S., Clench, M. H., Taylor, D. R., Borucki, M. J., Pollard, R. B. et al. (1993). Clostridium difficile diarrhea in patients with AIDS versus non-AIDS controls. Methods of treatment and clinical response to treatment. Journal of Clinical Gastroenterology 16, 192-4.
95. Macgowan, A. P., Brown, I., Feeney, R., Lovering, A., McCulloch, S. Y., Reeves, D. S. et al. (1995). Clostridium difficile associated diarrhoea and length of hospital stay. Journal of Hospital Infection 31, 241-4.
96. Riley, T. V., Codde, J. P. & Rouse, I. L. (1995). Increased length of stay due to Clostridium difficile associated diarrhoea. Lancet 345, 455-6.
97. Wilcox, M. H., Cunniffe, J. G., Trundle, C. & Redpath, C. (1996). Financial burden of hospital-acquired Clostridium difficile infection. Journal of Hospital Infection 34, 23-30.
98. Kofsky, P., Rosen, L., Reed, J., Tolmie, M. & Ufberg, D. (1991). Clostridium difficile - a common and costly colitis. Diseases of the Colon and Rectum 34, 244-8.