Molecular and pathologic characterization of an AIDS-related body cavity-based lymphoma, including ultrastructural demonstration of human herpesvirus-8: A case report

American Journal of Surgical Pathology

Volumn 22, Issue 4, 1998, Pages 493-499

  Hsi, Eric D ^a   Foreman, Kimberly E ^a   Duggan, Joan ^b   Alkan, Serhan ^a   Kauffman, Carol A ^b   Aronow, Herbert D ^b   Nickoloff, Brian J ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

^b VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

AIDS; Human herpesvirus; Lymphoma

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; AUTOPSY; CASE REPORT; EFFUSION; HERPES VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOPHENOTYPING; LYMPHOMA; MALE; ULTRASTRUCTURE;

ADULT; CYTOMEGALOVIRUS; DNA NUCLEOTIDYLTRANSFERASES; DNA, VIRAL; FATAL OUTCOME; HERPESVIRUS 4, HUMAN; HERPESVIRUS 8, HUMAN; HIV INFECTIONS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPHOMA, AIDS-RELATED; MALE; MICROSCOPY, ELECTRON; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER; RNA, VIRAL; SARCOMA, KAPOSI; SKIN NEOPLASMS; VDJ RECOMBINASES;

EID: 0031981549     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-199804000-00016     Document Type: Article

References (35)

1. Ansari MQ, Dawson DB, Nador R, Rutherford C, et al. Primary body cavity-based AIDS-related lymphomas. Am J Clin Pathol 1996;105:221-9.
2. Apolloni A, Sculley TB. Detection of A-type and B-type Epstein-Barr virus in throat washings and lymphocytes. Virol 1994;202: 978-81.
3. Arvanitakis L, Mesri EA, Nador RG, et al. Establishment and characterization of a primary effusion (body cavity-based) lymphonia cell line (BC-3) harboring Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in the absence of Epstein-Barr virus. Blood 1996;88:2648-54.
4. Beral V, Peterman T, Berkelman R, et al. AIDS-associated non-Hodgkin lymphoma. Lancet 1991;337:805-9.
5. Boshoff C, Schulz TF, Kennedy MM, et al. Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med 1995;1:1274-8.
6. Cesarman E, Chang Y, Moore PS, et al. Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med 1995;332:1186-91.
7. Cesarman E, Nador RG, Aozasa K, et al. Kaposi's sarcoma-associated herpesvirus in non-AIDS related lymphomas occurring in body cavities. Am J Pathol 1996;149:53-7.
8. Cesarman E, Nador RG, Bai F, et al. Sequence and expression analysis of a Kaposi's sarcoma associated herpesvirus region containing two genes possibly involved in malignant transformation. Mod Pathol 1996;9:109A. Abstract.
9. Cesarman E, Nador RG, Bai F, et al. Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma. J Virol 1996;70:8218-23.
10. Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science 1994;266:1865-9.
11. Foreman KE, Bacon P, Hsi ED, et al.. In situ PCR-based localization studies support the role of HHV-8 as the cause of two AIDS-related neoplasms: Kaposi's sarcoma and body cavity lymphoma. J Clin Invest 1997;99:2971-8
12. Foreman KE, Friborg J, Kong WP, et al. Propagation of a human herpesvirus from AIDS-associated Kaposi's sarcoma. N Engl J Med 1997;336:163-71.
13. Frank D, Cesarman E, Liu YF, et al. Posttransplantation lymphoproliferative disorders frequently contain type A and not type B Epstein-Barr virus. Blood 1995;85:1396-403.
14. Green I, Espiritu E, Ladanyi M, et al. Primary lymphomatous effusions in AIDS: a morphological, imnnmophenotypic. and molecular study. Mod Pathol 1995;8:39-45.
15. Karcher DS, Alkan S. Herpes-like DNA sequences, AIDS-related tumors, and Castleman's disease. N Engl J Med 1995;333:797-8; discussion 798-9.
16. Karcher D, Dawkins F, Garret C, et al. Body cavity based lym- phomas in HIV-infecled patients: B-cell lyniphoma with unusual clinical, immunophenotypic, and genotypic features. Lab Invest 1992;66:80A. Abstract.
17. Knowles DM, Inghirami G, Ubriaco A, et al. Molecular genetic analysis of three AIDS-associated neoplasms of uncertain lineage demonstrates their B-cell derivation and the possible pathogenetic role of the Epstein-Barr virus. Blood 1989;7:792-9.
18. Lee MS, Chang KS, Cabanillas F, et al. Detection of minimal residual cells carrying the (14;18) by DNA sequence amplification. Science 1987;237:175-8.
19. Levine AM. AIDS-associated malignant lymphoma. Med Clin North Am 1992;76:253-68.
20. Li MT, Lee HR, Yoon DW, et al. Kaposi's sarcoma-associated herpesvirus encodes a functional cyclin. J Virol 1997;71:1984-91.
21. Long AA, Komminoth P, Lee E, et al. Comparison of indirect and direct in-situ polymerase chain reaction in cell preparations and tissue sections. Detection of viral DNA, gene rearrangements and chromosomal translocations. Histochemistry 1993;99:151-62.
22. Mesri EA, Cesarman E, Arvanitakis L, et al. Human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus is a new transmissible virus that infects B cells. J Exp Med 1996;183:2385-90.
23. Moore PS, Boshoff C, Weiss RA, et al. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science 1996;274:1739-44.
24. Moore PS, Chang Y. Detection of herpesvirus-like DNA sequences in Kaposi's sarcoma in patients with and without HIV infection. N Engl J Med 1995;332:1181-5.
25. Nador RG, Cesarman E, Chadburn A, et al. Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus. Blood 1996;88:645-56.
26. Nador RG, Cesarman E, Knowles DM, et al. Herpes-like DNA sequences in a body-cavity-based lymphoma in an HIV-negative patient. N Engl J Med 1995;333:943.
27. Neipel F, Albrecht JC, Ensser A, et al. Human herpesvirus 8 encodes a homolog of interleukin-6. J Virol 1997;71:839-42.
28. Nuovo GJ. PCR in situ hybridization. In: Protocols and Applications. New York: Raven Press; 1994:1-246.
29. Otsuki T, Kumar S, Ensoli B, et al. Detection of HHV-8/KSHV DNA sequences in AIDS-associated extranodal lymphoid malignancies. Leukemia 1996;10:1358-62.
30. Renne R, Zhong W, Herndier B, et al. . Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med 1996;2:342-6.
31. Reynolds P, Saunders LD, Layefsky ME, et al. The spectrum of acquired immunodeficiency syndrome (AIDS)-associated malignancies in San Francisco, 1980-1987. Am J Epidemiol 1993;137: 19-30.
32. Roizman B. New viral footprints in Kaposi's sarcoma. N Engl J Med 1995;332:1227-8.
33. Said JW, Chien K, Takeuchi S, et al. Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells. Blood 1996;87:4937-43.
34. Segal GH, Jorgensen T, Masih AS, et al. Optimal primer selection for clonality assessment by polymerase chain reaction analysis: I. Low grade B-cell lymphoproliferative disorders of nonfollicular center cell type. Hum Pathol 1994;25:1269-75.
35. Walts AE, Shintaku IP, Said JW. Diagnosis of malignant lymphoma in effusions from patients with AIDS by gene rearrangement, Am J Clin Pathol 1990;94:170-5.