Calcium antagonist properties of the bisbenzylisoquinoline alkaloid cycleanine

Fundamental and Clinical Pharmacology

Volumn 12, Issue 2, 1998, Pages 182-187

  Martinez J A ^a   Bello, A ^a   Rubio, L L ^a   Rodriguez C ^a   Galan L ^a   Caudales, E ^a   Alvarez, J L ^a  

^a INSTITUTO DE CARDIOLOGÍA Y CIRUGÍA CARDIOVASCULAR   (Cuba)

Author keywords

Bisbenzylisoquinolines; Ca antagonists; Cycleanine

Indexed keywords

BISBENZYLISOQUINOLINE ALKALOID; CYCLEANINE; NIFEDIPINE; NORADRENALIN; POTASSIUM CHLORIDE;

ACTION POTENTIAL; ANIMAL TISSUE; AORTA; ARTICLE; CALCIUM ANTAGONISM; CALCIUM CURRENT; CONTROLLED STUDY; DRUG ISOLATION; HEART MUSCLE; IN VITRO STUDY; NONHUMAN; PATCH CLAMP; PLANT; PRIORITY JOURNAL; RABBIT; RAT; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTION;

EID: 0031980209     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1998.tb00939.x     Document Type: Article

References (23)

1. Alvarez JL, Dorticós F, Morlans J. Changes in electrical and mechanical activities of rabbit papillary muscle during hypoxic perfusion. J Physiol 1981 ; 77 : 807-12
2. Alvarez JL, Vassort G. Properties of the low-threshold Ca-current in isolated frog atrial cardiomyocytes. A comparison with the high-threshold Ca-current. J Gen Physiol 1992 ; 100 : 519-45
3. Bolton T. Mechanism of action of transmitters and other substances in smooth muscle. Physiol Rev 1979 ; 85 : 606-719
4. Cordell G, ed. Introduction to alkaloids. A biogenetic approach. New York: John Wiley and Sons; 1981
5. Delafontaine P. Update on calcium antagonists. Heart Disease Stroke 1992 ; 1 : 366-71
6. Dolores-Ivorra M, Lugnier C, Catret M, Anselmi E, Cortés D, D'Ocon P. Investigations on the dual contractile/relaxant properties showed by antioquine in rat aorta. Brit J Pharmacol 1993 ; 109 : 502-09
7. Fang DC, Jiang MX. Studies on tetrandrine calcium antagonistic action. Chinese Med J 1986 ; 99 : 638-44
8. Fang DC, Jiang MX. A new calcium antagonist of Chinese medicinal origin. J Hypert 1986 ; 4 suppl 6 : S150-2
9. Godfraind T, Miller R, Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol Rev 1986 ; 38 : 321-416
10. Godfraind T, Eglème C, Finet M, Jaumin P. The actions of nifedipine and nisoldipine on the contractile activity of human coronary arteries and human cardiac tissue in vitro. Pharmacol Toxicol 1987; 61 : 79-84
11. Kazda S, Garthoff B, Meyer H, Scholoßmann, Stoepel K, Towart R et al. Pharmacology of a new calcium antagonistic compound, isobutyl methyl 1,4 dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinecarboxylate (nisoldipine, BA Y K 5552). Arzneim Forsch 1980 ; 30 : 2144-62
12. Le Grand B, Hatem S, Deroubaix E, Couetil JP, Coraboeuf E. Calcium current depression in isolated human atrial myocytes after cessation of chronic treatment with calcium antagonists. Circ Res 1991 ; 69 : 292-300
13. Liu QY, Karpinsky E, Pang PKT. Tetrandrine inhibits both T and L calcium channel currents in ventricular cells. J Cardiovasc Pharmacol 1992 ; 20 : 513-19
14. Manske RHF, ed. The Alkaloids. New York: Academic Press; 1981
15. Nayler WG. Calcium Antagonists. London: Academic Press; 1988
16. Opie LH. Calcium antagonists, ventricular arrhythmias and sudden cardiac death: a major challenge for the future. J Cardiovasc Pharmacol 1992 ; 18 suppl 10 : S81-6
17. Packer M. Second generation calcium channel blockers in the treatment of chronic heart failure: are they any better than their predecessors? J Am Coll Cardiol 1989 ; 14 : 1339-42
18. Reicher-Reiss H, Barasch E. Calcium antagonists in patients with heart failure. A review. Drugs 1991 ; 42 : 343-64
19. Rubio LS, Garrido G, Llanes L, Alvarez JL. Effects of tetrandrine on Ca- and Na-currents of single bullfrog cardiomyocytes. J Mol Cell Cardiol 1993 ; 25 : 801-13
20. Schiff PL. Bisbenzylisoquinoline alkaloids. J Nat Prod 1987 ; 50 : 529-99
21. van Amsterdam FThM, Punt NC, Zaagsma J. Calcium antagonist tissue selectivity: relevance in ischemia. Prog Pharmacol Clin Pharmacol 1990 ; 8 : 53-77
22. Waters D. Proischemic complications of dihydropyridine calcium channel blockers. Circulation 1991 ; 84 : 2598-600
23. Zhang M, Zhang LZ, Lu JS. Effects of tetrandrine on rabbit platelet aggregation and platelet activating factor generation. Acta Pharmacol Sinica 1995 ; 16 : 209-12