Anti-inflammatory properties of new adamantane derivatives. Design, synthesis, and biological evaluation

Archiv der Pharmazie

Volumn 331, Issue 2, 1998, Pages 72-78

  Antoniadou Vyza, Ekaterini ^a   Avramidis, Nikos ^b   Kourounakis, Angeliki ^b   Hadjipetrou, Lygeri ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Adamantane derivatives; Anti inflammatory; Paw edema; Phlogistics

Indexed keywords

ADAMANTANE DERIVATIVE; ALPHA HYDROXY N [1 TRICYCLODEC 1 YL]BENZENE ACETAMIDE; ANTIINFLAMMATORY AGENT; DICLOFENAC; LIPOXYGENASE; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COMPLEMENT SYSTEM; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; LIPID PEROXIDATION; LIVER MICROSOME; MOUSE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ADAMANTANE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG DESIGN; FEMALE; MALE; MICE; MICE, INBRED BALB C; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031979826     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4184(199802)331:2<72::AID-ARDP72>3.0.CO;2-E     Document Type: Article

References (26)

1. Annu. Rep. Med. Chem. Academic Press Inc. 1993, 28, 109-118.
2. S.T. Chen, T.N. Lin, T.K. Lee, C.Y. Hsu, in Nonsteroiodal anti-inflammatory drugs, mechanism and clinical uses (Eds.: D. E. Furst, A. J. Lewis.), Marcel Dekker, 1994, Sec. Ed, p. 55.
3. J. Van Dijk, J.M. Zwagemakers, J. Med. Chem. 1977, 20, 1199-206.
4. M. E. Wolff in Burger's Medicinal Chemistry, Wiley, New York 1981, Part II, pp 557-560.
5. E. V. Bailey, T. W. Stone, Arch. Int. Pharmacodyn. 1975, 216, 246-262.
6. P. Tsitsa, E. Antoniadou-Vyza, S. J. Hamodrakas, E.E. Eliopoulos, A. Tsantili-Kakoulidou, C. Roussakis, Eur. J. Med. Chem. 1993, 28, 149-158.
7. E. Antoniadou-Vyza, P. Tsitsa, E. Hytiroglou, A. Tsantili-Kakoulidou, Eur. J. Med. Chem. 1996, 31, 105-110.
8. V. Cody, in Molecular Basis of Cancer (Ed: R. Rein) Alan R. Liss, New York 1984, Part II, pp. 275-284.
9. H. Stetter, E. Rauscher, Chem. Ber. 1960, 93, 2054.
10. P.E. Aldrich, E.C. Hermann, W.E. Meier, M. Paulshock, W.W. Prichard, A.J. Snyder, C.J. Watts, J. Med. Chem. 1971, 14, 535-543.
11. S. Hamodrakas, A. Perrakis, E. Antoniadou-Vyza, Acta Cryst. 1996, C 52, 677-679.
12. A. Gavalas, L. Kourounakis, D. Litina, P. Kourounakis. Arzneim.-Forsch./Drug Res. 1991, 41, 423.
13. L. Hadjipetrou-Kourounakis, E. Rekka, A. Kourounakis, Ann. N.Y. Acad. Sci. 1992, 650, 19.
14. E. Rekka, P.N. Kourounakis, J. Pharm. Pharmacol. 1991, 43, 486.
15. A. Gavalas, P. Victoratos, M. Yiangou, L. Hadjipetrou-Kourounakis, E. Rekka, P. Kourounakis, Intern. J. Neuroscience 1994, 74, 259.
16. G.R. Laauretti, A.L. Mattos, I.C Lima, Reg Anesth. 1997, 22, 243-248.
17. R. Vinegar, W. Schreiber, R. Hugo, J. Pharmac. Exp. Ther. 1969, 166, 96.
18. K. Gado, G. Gigler, Agents Actions 1991, 32, 119.
19. J.P. Taragre, A. Delhon, M. Aliaga, M. Barbara, F. Bruniguel, V. Caillot, L. Puech, N. Consul, J. Tisue-Versailles, Pharmacol. Res. 1989, 21, 375.
20. C.V. Wedmore, T.J. Williams, Nature 1981, 289, 646.
21. L.L. Nickerson-Nutter, E.D. Medvedeff, Arthritis Reum. 1996, 39, 515.
22. J.M. Masso, A.M. Villar, J.R. Conde, J. Martorell, Arzneim.-Forsch./Drug Res. 1994, 44, 68.
23. A. Lewis, J. Cottney, D.J. Nelson, Eur. J. Pharmacol. 1976, 40, 1.
24. E. Arrigoni-Martelli, P. Schiatti, D. Selva, Pharmacology 1971, 5, 215.
25. R.J. Wojnar, T. Heam, S. Starkweather, J Allergy Clin. Immunol. 1980, 66, 37.
26. J. Neumuller, M. Tohidast-Akrad, Arzneim.-Forsch./Drug Res. 1994, 44, 636.