Metabolic interaction between toluene, trichloroethylene and n-hexane in humans

Scandinavian Journal of Work, Environment and Health

Volumn 24, Issue 1, 1998, Pages 30-37

  Bælum, Jesper ^a,c   Mølhave, Lars ^a   Hansen, Steen Honoré ^b   Væth, Michael ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

End exhaled air; Flow limitation; Metabolites

Indexed keywords

ACETONYLACETONE; HEXANE; HIPPURIC ACID; ORTHO CRESOL; TOLUENE; TRICHLOROACETIC ACID; TRICHLOROETHANOL; TRICHLOROETHYLENE;

ADULT; ARTICLE; BREATH ANALYSIS; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; MALE; METABOLISM; NORMAL HUMAN; PRIORITY JOURNAL; URINARY EXCRETION;

EID: 0031979377     PISSN: 03553140     EISSN: None     Source Type: Journal    
DOI: 10.5271/sjweh.275     Document Type: Article

References (22)

1. Toftgård R, Gustafsson J-Å. Biotransfomation of organic solvents: a review. Scand J Work Environ Health 1980;6:1-18.
2. Bælum J. Human solvent exposure: factors influencing the pharmacokinetics and acute effects. Pharmacol Toxicol 1991;68 suppl 1:1-36.
3. Sato A, NakajimaT, Fujiwara Y, Murayama N. A pharmacokinetic model to study the excretion of trichloroethylene and its metabolites after an inhalation exposure. Br J Ind Med 1977;34:56-63.
4. Perbellini L, Brugnone F, Pastorelli G, Grigolini L. Urinary excretion of n-hexane metabolites in rats and humans. Int Arch Occup Environ Health 1979;42:349-54.
5. Balum J, Mølhave L, Honoré Hansen S, Døssing M. Hepatic metabolism of toluene after gastrointestinal uptake in humans. Scand J Work Environ Health 1993;19:55-2.
6. Arbejdstilsynet [the Danish Labour Inspection]. Grænseværdier for stoffer og materialer [Occupational exposure limits]. Copenhagen: Arbejdstilsynet, 1992. At anvisning Nr 3.1.0.2.
7. Montgomery DC. Design and analysis of experiments. Second edition. New York (NY): John Wiley and Sons, 1984.
8. Veulemans H, Van Vlem E, Janssen H, Masschelein R, Leplat A. Experimental human exposure to n-hexane: study of the uptake and elimination, and of n-hexane concentration in peripheral venous blood. Int Arch Occup Environ Health 1982;49:251-63.
9. Sherwood RJ. Ostwald solubility coefficients of some industrially important substances. Br J Ind Med 1976;33:106-7.
10. Hansen SH, Døssing M. Determination of urinary hippuric acid and o-cresol, as indices of toluene exposure, by liquid chromatography on dynamically modified silica. J Chromatograph 1982;229:141-8.
11. Christensen JM, Rasmussen K, Købben B. Automatic headspace gas chromatographic method for the simultaneous determination of trichloroethylene and metabolites in blood and urine. J Chromatograph 1988;442:317-23.
12. Tardif R, Laparé S, Plaa GL, Brodeur J. Effect of simultaneous exposure to toluene and xylene on their respective biological exposure indices in humans. Int Arch Occup Environ Health 1991;63:279-84.
13. Nakajima T, Wang R, Elovaara E, Park SS, Gelboin HV, Vainio H. A comparative study on the contribution of cytochrome P450 isozymes to metabolism of benzene, toluene and trichloroethylene in rat liver. Biochem Pharmacol 1992;43(2):251-7.
14. Nakajima T, Wang R, Katakura Y, Kishi R, Elovaara E, Park SS, et al. Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIIE1 and P450IIC1 content. J Pharmacol Exp Ther 1992;261(3):869-74.
15. Tassaneeyakul W, Birkett DJ, Edwards JW, Veronese ME, Tukey RH, Miners JO. Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, n- and p-xylene. J Pharmacol Exp Ther 1996;276(1):101-8.
16. Toftgård R, Haaparanta T, Eng L, Halpert J. Rat Lung and liver microsomal cytochrome P-450 isozymes involved in the hydroxylation of n-hexane. Biochem Pharmacol 1986;35(21): 3733-8.
17. Lapadula DM, Habig C, Gupta RT, Abou-Donia MB. Induction of cytochrom P450 izoenzymes by simultaneous inhalation exposure of hens to n-hexane and methyl iso-buthyl ketone (MiBK). Biochem Pharmacol 1991;41(6/7):877-83.
18. Tardif R, Sato A, Laparé S, Brodeur J. Ethanol induced modification of m-xylene toxicokinetics in humans. Occup Environ Med 1994;51:187-91.
19. Quistorff B. Metabolic heterogeneity of liver parenchymal cells; investigated by digitonin perfusion techniques. Copenhagen (Denmark): Institute for Medical Biochemistry and Genetics, University of Copenhagen, 1994.
20. Bass L, Keiding S, Tygstrup N. Enzymatic elimination of substrates flowing through the intact liver. J Theor Biol 1976;61:393-409.
21. Wallén M, Holm S, Byfält Nordqvist M. Coexposure to toluene and p-xylene in man: uptake and elimination. Br J Ind Med 1985;42:111-6.
22. Müller G, Spassowski M, HenschlerD. Metabolism of trichloroethylene in man III: interaction of trichloroethylene and ethanol. Arch Toxicol 1975;33:173-89.