Importance of sialic acid in recombinant thrombomodulin in terms of pharmacokinetics and separation of desialyzed glycoprotein

Biological and Pharmaceutical Bulletin

Volumn 21, Issue 4, 1998, Pages 382-385

  Edano, Toshiyuki ^a   Koshi, Tomoyuki ^a   Yoshizaki, Hideo ^a   Kumai, Natuyo ^a   Habata, Yuriko ^a   Koide, Takashi ^a   Mizoguchi, Toshimi ^a   Yamamoto, Susumu ^a   Kimata, Hideki ^a   Ohkuchi, Masao ^a  

^a KOWA COMPANY LTD   (Japan)

Author keywords

Galactose oxidase; Plasma clearance; RCA lectin; Sialyltransferase; Thrombomodulin

Indexed keywords

ANTIBODY; ERYTHROPOIETIN; GALACTOSE; GLYCOPROTEIN; GLYCOSAMINOGLYCAN; LECTIN; RECOMBINANT THROMBOMODULIN; SIALIC ACID; SIALIDASE; SIALYLTRANSFERASE; THROMBOMODULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; ENZYME LINKED IMMUNOSORBENT ASSAY; MALE; MOUSE; NONHUMAN; PLASMA CLEARANCE; POLYACRYLAMIDE GEL ELECTROPHORESIS;

EID: 0031979283     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.21.382     Document Type: Article

References (23)

1. EsMon C. T., Owen W. G., Proc. Natl. Acad. Sci. U.S.A., 78, 2249-2252 (1981).
2. Owen W. G., Esmon C. T., J. Biol. Chem., 256, 5532-5535 (1981).
3. Esmon N. L., Owen W. G., Esmon C. T., J. Biol. Chem., 257, 859-864 (1982).
4. Esmon C. T., Esmon N. L., Harris K. W., J. Biol. Chem., 257, 7944-7947 (1982).
5. Esmon N. L., Carroll R.C., Esmon C. T., J. Biol. Chem., 258, 12238-12242 (1983).
6. Ishii H., Majerus P. W., J. Clin. Invest., 76, 2178-2181 (1985).
7. Yamamoto S., Mizoguchi T., Tamaki T., Ohkuchi M., Kimura S., Aoki N., J. Biochem. (Tokyo), 113, 433-440 (1993).
8. Bourin M.-C., Lindahl U., Biochem. J., 270, 419-425 (1990).
9. Iwasaki A., Doi T., Suda M., Mizoguchi T., Kimura S., Thromb. Haemostas., 69, 737 (1993).
10. Edano T., Kumai N., Mizoguchi T., Ohkuchi M., Int. J. Biochem. Cell Biol., in press.
11. Morell A. G., Gregoriadis G., Scheinberg I. H., J. Biol. Chem., 246, 1461-1467 (1971).
12. Ashwell G., Harford J., Ann. Rev. Biochem., 51, 531-554 (1982).
13. Goldwasser E., Kung C. K.-H., Eliason J., J. Biol. Chem., 249, 4202-4206 (1974).
14. Fukuda M. N., Sasaki H., Lopez L., Fukuda M., Blood, 73, 84-89 (1989).
15. Hara S., Yamaguchi M., Takemoh Y., Fukuhara K., Ogura H., Nakamura M., Anal. Biochem., 179, 162-166 (1989).
16. Kimura S., Nagoya T., Aoki N., J. Biochem. (Tokyo). 105, 478-483 (1989).
17. Takano S., Kimura S., Ohdama S., Aoki N., Blood, 76, 2024-2029 (1990).
18. Yamaoka K., Tanigawara Y., Nakagawa T., Uno T., J. Pharmacobio-Dyn., 4, 879-885 (1981).
19. Gibaldi M., Nagashima P., Levy G., J. Pharm. Sci., 58, 193-197 (1969).
20. Smedsrød B., Einarsson M., Pertoft H., Thromb. Haemostas., 59, 480-484 (1982).
21. Okuyama T., The Pharmaceutical Monthly, 30, 2503-2511(1988).
22. Lukowsky W. A., Painter R. H., Can. J. Biochem., 50, 909-917 (1972).
23. Spivak J. L., Hogans B. B., Blood, 73, 84-89 (1989).