Transferable, Plasmid-mediated VanB-type glycopeptide resistance in Enterococcus faecium

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 4, 1998, Pages 963-964

  Rice, Louis B ^a,b   Carias, Lenore L ^b   Donskey, Curtis L ^b   Rudin, Susan D ^b  

^a LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL MUTATION; ENTEROCOCCUS FAECALIS; NONHUMAN; OPERON; PLASMID; PRIORITY JOURNAL; STRAIN DIFFERENCE;

EID: 0031979234     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.4.963     Document Type: Article

References (19)

1. Bonafede, M. E., L. L. Carias, and L. B. Rice. 1997. Enterococcal transposon Tn5384: evolution of a composite transposon through cointegration of enterococcal and staphylococcal plasmids. Antimicrob. Agents Chemother. 41:1854-1858.
2. Boyce, J. M., S. M. Opal, J. W. Chow, M. J. Zervos, G. Potter-Bynoe, C. B. Sherman, R. L. Romulo, S. Fortna, and A. A. Medeiros. 1994. Outbreak of multidrug-resistant Enterococcus faecium with transferable vanB class vancomycin resistance. J. Clin. Microbiol. 32:1148-1153.
3. Centers for Disease Control and Prevention. 1993. Nosocomial enterococci resistant to vancomycin - United States, 1989-1993. Morbid. Mortal. Weekly Rep. 42:597-599.
4. Christie, P. J., R. Z. Korman, S. A. Zahler, J. C. Adsit, and G. M. Dunny. 1987. Two conjugation systems associated with plasmid pCF10: identification of a conjugative transposon that transfers between Streptococcus faecalis and Bacillus subtilis. J. Bacteriol. 169:2529-2536.
5. Clewell, D. B. 1981. Plasmids, drug resistance and gene transfer in genus Streptococcus. Microbiol. Rev. 45:409-436.
6. Ehrenfeld, E. E., and D. B. Clewell. 1987. Transfer functions of the Streptococcus faecalis plasmid pAD1 : organization of plasmid DNA encoding response to sex pheromone. J. Bacteriol. 169:3473-3481.
7. Eliopoulos, G. M., C. Wennersten, S. Zighelboim-Daum, E. Reiszner, D. Goldmann, and R. C. Moellering, Jr. 1988. High-level resistance to gentamicin in clinical isolates of Streptococcus (Enterococcus) faecium. Antimicrob. Agents Chemother. 32:1528-1532.
8. B two-component regulatory system in Enterococcus faecalis V583. J. Bacteriol. 178:1302-1309.
9. Heaton, M. P., L. F. Discotto, M. J. Pucci, and S. Handwerger. 1996. Mobilization of vancomycin resistance by transposon-mediated fusion of a VanA plasmid with an Enterococcus faecium sex pheromone-response plasmid. Gene 171:9-17.
10. Jacob, A. E., and S. J. Hobbs. 1974. Conjugal transfer of plasmid-borne multiple antibiotic resistance in Streptococcus faecalis var. zymogenes. J. Bacteriol. 117:360-372.
11. Lacroix, J. M., and C. B. Walker. 1995. Detection and incidence of the tetracycline resistance determinant tet(M) in the microflora associated with adult perodontitis. J. Periodontol. 66:102-108.
12. National Committee for Clinical Laboratory Standards. 1993. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. M7-A3. National Committee for Clinical Laboratory Standards, Wayne, Pa.
13. Quintiliani, R., Jr., and P. Courvalin. 1996. Characterization of Tn1547, a composite transposon flanked by the IS16 and IS256-like elements, that confers vancomycin resistance in Enterococcus faecium BM4281. Gene 172: 1-8.
14. Rice, L. B., S. H. Marshall, and L. L. Carias. 1992. Tn5381, a conjugative transposon identifiable as a circular form in Enterococcus faecalis. J. Bacteriol. 174:7308-7315.
15. Storrs, M. J., C. Poyart-Salmeron, P. Trieu-Cuot, and P. Courvalin. 1991. Conjugative transposition of Tn916 requires the excisive and integrative activities of the transposon-encoded integrase. J. Bacteriol. 173:4347-4352.
16. Swinfield, T.-J., J. D. Oultram, D. E. Thompson, J. K. Brehm, and N. P. Minton. 1990. Physical characterization of the replication region of Streptococcus faecalis plasmid pAMβ1. Gene 87:79-90.
17. Thorisdottir, A. S., L. L. Carias, S. H. Marshall, M. Green, M. J. Zervos, C. Giorgio, L. A. Mermel, J. M. Boyce, A. A. Medeiros, H. Fraimow, and L. B. Rice. 1994. IS6770, an enterococcal insertion-like clement useful for determining the clonal relationship of clinical enterococcal isolates. J. Infect. Dis. 170:1539-1548.
18. Woodford, N., P. R. Chadwick, D. Morrison, and B. D. Cookson. 1997. Strains of glycopeptide-resistant Enterococcus faecium can alter their van genotypes during an outbreak. J. Clin. Microbiol. 35:2966-2968.
19. Woodford, N., B. L. Jones, Z. Baccus, H. A. Ludlam, and D. F. Brown. 1995. Linkage of vancomycin and high-level gentamicin resistance genes on the same plasmid in a clinical isolate of Enterococcus faecalis. J. Antimicrob. Chemother. 35:179-184.