Expression of proliferating cell nuclear antigen (PCNA) and apoptosis related antigen (Le(Y)) in epithelial skin tumors

American Journal of Dermatopathology

Volumn 20, Issue 2, 1998, Pages 164-169

  Tsuji, Takuo ^a   Kitajima, Shinji ^a   Koashi, Yusuke ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

Immunohistochemistry; Le(Y); PCNA; Skin tumors

Indexed keywords

CYCLINE; LE(Y) ANTIGEN;

ACTINIC KERATOSIS; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; BOWEN DISEASE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM TUMOR; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINIZATION; PRIORITY JOURNAL; SEBORRHEIC KERATOSIS; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; TISSUE SECTION; TUMOR DIFFERENTIATION;

BOWEN'S DISEASE; CARCINOMA IN SITU; CARCINOMA, SQUAMOUS CELL; HUMANS; IMMUNOHISTOCHEMISTRY; KERATOSIS, SEBORRHEIC; LEWIS BLOOD-GROUP SYSTEM; PROLIFERATING CELL NUCLEAR ANTIGEN; SKIN NEOPLASMS;

EID: 0031979099     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000372-199804000-00011     Document Type: Article

References (23)

1. Lever WF, Schaumburg-Lever G. Tumors and cysts of the epidermis. In: Histopathology of the skin, 7th edn. New York: JB Lippincott, 1990:523-77.
2. Celis JE, Celis A. Cell cycle-dependent variations in the distribution of the nuclear protein cyclin proliferating cell nuclear antigen in cultured cells: Subdivision of S phase. Proc Natl Acad Sci USA 1985;82:3262-6.
3. Morris GF, Mathews MB. Regulation of proliferating cell nuclear antigen during the cell cycle. J Biol Chem 1989;264:13856-64.
4. Moore KS, Sullivan K, Tan EM, Prystowsky MB. Proliferating cell nuclear antigen/cyclin is an interleukin 2-responsive gene. J Biol Chem 1987;262:8447-50.
5. Y antigen in human immunodeficiency virus-infected human T cell lines and in peripheral lymphocytes of patients with acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC). J Exp Med 1988;167:323-31.
6. Y antigen expression in the CD8 subpopulation in peripheral blood of patients with viral hepatitis. In: Hollinger FB, Lemon SM, Margolis HS, eds. Proceedings of the 1990 international symposium on viral hepatitis and liver disease. Baltimore: Williams & Wilkins, 1991:289-90.
7. Y antigen expression is correlated with apoptosis (programmed cell death). Glycobiology 1993;3:381-90.
8. Y and nick-end labelling are positive in spinal motor neurons in amyotrophic lateral sclerosis. Acta Neuropathol 1994;88:207-11.
9. Y antigen, apoptosis and differentiation in human lung cancer cells. Anticancer Res 1995;15:2137-44.
10. Y antigen by 5-aza-2′-deoxycytidine in association with differentiation and apoptosis in human pancreatic cancer cells. Anticancer Res 1996;16:735-40.
11. Wyllie AH. Cell death: A new classification separating apoptosis from necrosis. In: Bowen ID, Lockskin RA, eds. Cell death in biology and pathology. London: Chapman & Hall, 1981:9-34.
12. Umansky SR. The genetic program of cell death: hypothesis and some applications: Transformation, carcinogenesis, ageing. J Theor Biol 1982;97:591-602.
13. Arends MJ, Wyllie AH. Apoptosis: mechanism and roles in pathology. Int Rev Exp Pathol 1991;32:223-54.
14. Hall PA, Levison DA, Woods AL, Yu CC, Kellock DB, Watkins JA, Bames DM, Gillett CE, Camplejohn R, Dover R, Waseem NH, Lane DP. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 1990;162:285-94.
15. Waseem NH, Lane DP. Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nuclear form. J Cell Sci 1990;96:121-9.
16. Fesus L, Davies PJA, Piacentini M. Apoptosis: molecular mechanisms in programmed cell death. Eur J Cell Biol 1991;56:170-7.
17. Alison MR, Sarraf CE. Apoptosis: a gene-directed programme of cell death. J R Coll Physicians Lond 1992;26:25-35.
18. Hockenberg D, Zutter M, Hickey W, Nahm M, Korsmeyer SJ. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci 1991;88:6961-5.
19. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
20. Kerr JFR, Harmon BV. Definition and incidence of apoptosis: a historical perspective. In: Tomei LD, Copa FO, eds. Apoptosis: the molecular basis of cell death. Current communications in cell and nuclear biology. New York: Cold Spring Harbor Laboratory Press, 1991.
21. Weedon D. Apoptosis. Adv Dermatol 1990;5:243-56.
22. Hashimoto K. Apoptosis in lichen planus and several other dermatoses - infra-epidermal cell death with filamentous degeneration. Acta Derm Venereol (Stockh) 1976;56:187-210.
23. Olson RL, Everett MA. Epidermal apoptosis: cell deletion by phagocytosis. J Cutan Pathol 1975;2:53-7.