Increased thromboxane metabolites excretion in liver cirrhosis

Thrombosis and Haemostasis

Volumn 79, Issue 4, 1998, Pages 747-751

  Davì, Giovanni ^a   Ferro, Domenico ^b   Basili, Stefania ^b   Iuliano, Luigi ^b   Camastra, Caterina ^b   Giammarresi, Carlo ^a   Santarone, Stella ^a   Rocca, Bianca ^c   Landolfi, Raffaele ^c   Ciabattoni, Giovanni ^c   Cordova, Corrado ^b   Violi, Francesco ^b  

^a UNIVERSITY OF CHIETI   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

11 OXOTHROMBOXANE B2; 2,3 DINORTHROMBOXANE B2; THROMBOXANE; THROMBOXANE A2;

ADULT; AGED; ARTICLE; BIOSYNTHESIS; BLOOD CLOTTING; CELL DAMAGE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LIVER CIRRHOSIS; LIVER FUNCTION; MALE; OXIDATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; THROMBOCYTE; THROMBOCYTE ACTIVATION; URINARY EXCRETION;

EID: 0031978947     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1615058     Document Type: Article

References (27)

1. 2 and prostacyclin in decompensated liver disease and hepatorenal syndrome. Gastroenterology 1991; 100: 1069-77.
2. Guarner F, Guarner C, Prieto J, Colina I, Quiroga J, Casas J, Freixa R, Rosello J, Gelpi E, Balanzo J. Increased synthesis of systemic prostacyclin in cirrhotic patients. Gastroenterology 1986; 90: 687-94.
3. Laffi G, Cinotti S, Filimberti E, Ciabattoni G, Caporale R, Marra F, Melani L, Grossi A, Gentilini P. Defective aggregation in cirrhosis is independent of in vivo platelet activation. J Hepatol 1996; 24: 436-43.
4. FitzGerald GA, Brash AR, Falardeau P, Gates JA. Estimated rate of prostacyclin secretion into the circulation of normal man. J Clin Invest 1981; 68: 1272-6.
5. FitzGerald GA, Pedersen AK, Patrono C. Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease. Circulation 1983; 67:1174-7.
6. Violi F, Leo R, Vezza E, Basili S, Cordova C, Balsano F, and the CALC Group. Bleeding time in patients with cirrhosis: relation with degree of liver failure and clotting abnormalities. J Hepatol 1994; 20: 531-6.
7. 2 in man: identification of twenty urinary metabolites. J Biol Chem 1981; 256: 8384-93.
8. 2 in man. Biochim Biophys Acta 1989; 992: 66-70.
9. Violi F, Ferro D, Basili S, Saliola S, Quintarelli C, Alessandri C, Cordova C. Association between low-grade disseminated intravascular coagulation and endotoxemia in patients with liver cirrhosis. Gastroenterology 1995; 109: 531-39.
10. Pugh RNH, Murray-Lyon IM, Dawson JL. Transection of oesophagus for bleeding oesophagus varices. Br J Surg 1973; 60: 646-9.
11. Conn HO. A peak at the Child-Turcotte classification. Hepatology 1981; 1: 673-6.
12. Clauss A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol 1957; 17: 237-40.
13. Cordova C, Violi F, Alessandri C, Ferro D, Saliola M, Musca A, Balsano F. Prekallikrein and factor VII as prognostic indexes of liver failure. Am J Clin Pathol 1986; 85: 579-82.
14. Pelzer H, Schwartz A, Stuber W. Determination of human prothrombin activation fragment 1+2 in plasma with an antibody against a synthetic peptide. Thromb Haemost 1991; 65: 153-9.
15. Violi F, Ferro D, Basili S, Quintarelli C, Musca A, Cordova C, Balsano F and the CALC Group. Hyperfibrinolysis resulting from clotting activation in patients with different degrees of liver cirrhosis. Hepatology 1993; 17: 78-83.
16. Carr JM. Disseminated intravascular coagulation in cirrhosis. Hepatology 1989; 10: 103-10.
17. 2 in human plasma and urine. Biochim Biophis Acta 1987; 918: 293-7.
18. Di Minno G, Davì G, Margaglione M, Cirillo F, Grandone E, Ciabattoni G, Catalano I, Strisciuglio P Andria G, Patrono C Mancini M. Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism. J Clin Invest 1993; 92: 1400-6.
19. 2 production in healthy subjects. Thromb Res 1980; 17: 317-27.
20. Armitage P, Berry G. Statistical methods in medical research. 2nd ed. Oxford: Blackwell Scientific Publications, 1990: 200-15.
21. FitzGerald GA, Brash AR, Oates JA, Pedersen AK. Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man. J Clin Invest 1983; 72: 1336-43.
22. Laffi G, Cominelli F, Ruggiero M, Fedi S, Chiarugi VP, La Villa G, Pinzani M, Gentilini P. Altered platelet function in cirrhosis of the liver: impairment of inositol lipid and arachidonic acid metabolism in response to agonists. Hepatology 1988; 6: 1620-6.
23. Laffi G, Marra F, Gresele P, Romagnoli P, Palermo A, Bartolini O, Simoni A, Orlandi L, Selli ML, Nenci GG, Gentilini P. Evidence for a Storage Pool Defect in Platelets from Cirrhotic Patients with Defective Aggregation. Gastroenterology 1992; 103: 641-6.
24. Violi F, Leo R, Davì G, Praticò D, Iuliano L, Balsano F. Thrombocytopenia and thrombocytopathia in liver cirrhosis. Platelets 1992; 3: 233-9.
25. Ferro D, Quintarelli C, Lattuada A, Leo R, Alessandroni M, Mannucci PM, Violi F. High plasma von Willebrand factor as marker of endothelial perturbation in liver cirrhosis: relationship to endotoxemia. Hepatology 1996 23: 1377-83.
26. Bauer KA, Rosemberg RD. The pathophysiology of the prothrombotic state in humans: insights gained from studies using markers of hemostatic system activation. Blood 1987; 70: 343-50.
27. Beer JH, Clerici N, Baillod P, von Felten A, Schlappritzi E, Buchi L. Quantitative and qualitative analysis of platelet GPIb and von Willebrand factor in liver cirrhosis. Thromb Haemost 1995; 73: 601-9.