Oxindole, a sedative tryptophan metabolite, accumulates in blood and brain of rats with acute hepatic failure

Journal of Neurochemistry

Volumn 70, Issue 5, 1998, Pages 1998-2003

  Carpenedo, Raffaella ^a   Mannaioni, Guido ^a   Moroni, Flavio ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Hepatic failure; Liver; Oxindole; Quinolinic acid; Sedation; Serotonin; Tryptophan; Tryptophanase

Indexed keywords

GALACTOSAMINE; INDOLE; NEOMYCIN; OXINDOLE; QUINOLINIC ACID; SEROTONIN; THIOACETAMIDE; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE DISEASE; AMINO ACID METABOLISM; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; BLOOD PRESSURE; BRAIN LEVEL; BRAIN METABOLISM; CONTROLLED STUDY; HEPATIC ENCEPHALOPATHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER DISEASE; LIVER FAILURE; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; RAT; TRYPTOPHAN BRAIN LEVEL; TRYPTOPHAN METABOLISM;

ANIMALIA;

EID: 0031978616     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.70051998.x     Document Type: Article

References (38)

1. Basile A. S., Jones E. A., and Skolnick P. (1991) The pathogenesis and treatment of hepatic encephalopathy: evidence for the involvement of benzodiazepine receptor ligands. Pharmacol. Rev. 42, 27-71.
2. Basile A. S., Saito K., Li H., and Heyes M. P. (1995) The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy in animal models of fulminant hepatic failure. J. Neurochem. 64, 2607-2614.
3. Bengtsson F. (1987) Chronic portal-systemic encephalopathy: an experimental study with special reference to brain serotonin [Bulletin 66, Department of Surgery; Ph.D. Thesis). University of Lund, Lund, Sweden.
4. Bengtsson F., Bugge M., Johansen K. H., and Butterworth R. F. (1991) Brain tryptophan hydroxylation in the portacaval shunted rat: a hypothesis for the regulation of serotonin turnover in vivo. J. Neurochem. 56, 1069-1074.
5. Bergqvist P. B. F. (1997) Tryptophan-related neurotransmission in the brain. Disturbances associated with experimental hepatic encephalopathy [Ph.D. Thesis]. University of Lund, Lund, Sweden.
6. Bergqvist P. B. F., Heyes M. P., Bugge M., and Bengtsson F. (1995a) Brain quinolinic acid in chronic hepatic encephalopathy: effects of an exogenous ammonium acetate challenge. J. Neurochem. 65, 2235-2240.
7. Bergqvist P. B. F., Vogels B. A. P. M., Bosman D. K., Maas M. A. V., Hjorth S., Chamuleau R. A. F. M., and Bengtsson F. (1995b) Neocortical dialysate monoamines of rats after acute, subacute, and chronic liver shunt. J. Neurochem. 64, 1238-1244.
8. Bucci L., Cardelli M., Chiavarelli R., Massotti M., and Morisi G. (1980) Behavioral, electroencephalographic and biochemical changes in porto-cava shunted rats. Int. J. Neurosci. 10, 129-134.
9. Butterworth R. (1992) Pathogenesis and treatment of portal systemic encephalopathy: an update. Dig. Dis. Sci. 37, 321-327.
10. Cabrera J., Cordoba J., and Blei A. T. (1997) Morning melatonin levels and sleep disturbance in patients with cirrhosis, in Advances in Hepatic Encephalopathy and Metabolism in Liver Disease (Record C. and Al-Mardini H., eds), pp. 501-507. Ipswich Book, Newcastle.
11. Capocaccia L., Merli M., and Riggio O., eds (1995) Advances in Hepatic Encephalopathy and Metabolic Nitrogen Exchange, pp. 99-142. CRC Press, Boca Raton, Florida.
12. Carpenedo R., Chiarugi A., Russi P., Lombardi G., Carlà V., Pellicciari R., Mattoli L., and Moroni F. (1994) Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenic acid and have sedative and anticonvulsant activities. Neuroscience 61, 237-244.
13. Carpenedo R., Carlà V., Chiarugi A., Mannaioni G., Galli A., Moneti G., and Moroni F. (1996) Identification and measurement in the mammalian brain of 2-indolinone, a tryptophan metabolite provided with neurodepressant properties. Soc. Neurosci. Abstr. 22, 2108.
14. Carpenedo R., Carlà V., Moneti G., Chiarugi A., and Moroni F. (1997) Identification and measurement of oxindole (2-indolinone) in the mammalian brain and other rat organs. Anal. Biochem. 244, 74-79.
15. Chiarugi A., Carpenedo R., Molina M. T., Mattoli L., Pellicciari R., and Moroni F. (1995) Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase. J. Neurochem. 65, 1176-1183.
16. Chiarugi A., Carpenedo R., and Moroni F. (1996) Kynurenine disposition in blood and brain of mice: effects of selective inhibitors of kynurenine hydroxylase and of kynureninase. J. Neurochem. 67, 692-698.
17. Conn H. E. and Lieberthal M. M. (1979) The Hepatic Coma Syndromes and Lactulose. Williams and Wilkins, Baltimore.
18. Curzon G., Kantamaneni B. D., Winch J., Rojas-Bueno A., Murray-Lyon I. M., and Williams R. (1973) Plasma and brain tryptophan changes in experimental acute hepatic failure. J. Neurochem. 21, 137-145.
19. Felipo V. and Grisolía S. (1994) Hepatic Encephalopathy, Hyperammonemia and Ammonia Toxicity, pp. 79-89. Plenum Press, New York.
20. Hirayama C. (1971) Tryptophan metabolism in liver disease. Clin. Chim. Acta 32, 191-197.
21. Kawata Y., Tani S., Sato M., Katsube Y., and Tokushige M. (1991) Preliminary X-ray crystallographic analysis of tryptophanase from Escherichia coli. FEBS Lett. 284, 270-272.
22. 14C]indole in the rat. Biochem. J. 98, 266-277.
23. Moroni F., Lombardi G., Carlà V., Lal S., Etienne P. E., and Nair N. P. V. (1986a) Increase in the content of quinolinic acid in cerebrospinal fluid and frontal cortex of patients with hepatic failure. J. Neurochem. 47, 1667-1671.
24. Moroni F., Lombardi G., Carlà V., Pellegrini D., Carassale G. L., and Cortesini C. (1986b) Content of quinolinic acid and of other tryptophan metabolites increases in brain regions of rats used as experimental models of hepatic encephalopathy. J. Neurochem. 46, 869-874.
25. Moroni F., Carpenedo R., Mannaioni G., Galli A., Chiarugi A., Carlà V., and Moneti G. (1997) Studies on the pharmacological properties of oxindole and 5 hydroxyindole: are they involved in hepatic encephalopathy?, in Advances in Cirrhosis, Hyperammonemia and Hepatic Encephalopathy (Felipo V. and Grisolía S., eds), pp. 57-75. Plenum Press, New York.
26. Mullen K. D. (1995) Optimal animal models for the study of hepatic encephalopathy and nitrogen metabolism, in Advances in Hepatic Encephalopathy and Metabolic Nitrogen Exchange (Capocaccia L., Merli M., and Riggio O., eds), pp. 279-292. CRC Press, Boca Raton, Florida.
27. Ono J., Huston D. G., Dombro R. S., Levi U. E., Livingstone A., and Zeppa R. (1978) Tryptophan and hepatic coma. Gastroenterology 74, 196-200.
28. Orcutt J. A., Prytherch J. P., Konicov M., and Michaelson S. M. (1964) Some new compounds exhibiting selective CNS-depressant activities. Arch. Int. Pharmacodyn. 152, 121-131.
29. Price K. L. (1986) Aminoglycoside research 1975-1985; prospects for development of improved agents. Antimicrob. Agents Chemother. 29, 543-547.
30. Rossi-Fanelli F., Freund H., Krause R., Smith A. R., James H., Castorina-Ziparo S., and Fischer J. E. (1982) Induction of coma in normal dogs by infusion of aromatic amino acids and its prevention by the addition of branched chain amino acids. Gastroenterology 83, 664-671.
31. Sherlock S. (1975) Diseases of the Liver and Biliary System. Blackwell, Oxford.
32. Sherlock S. (1997) Hepatic encephalopathy: historical review up to 1975, in Advances in Hepatic Encephalopathy and Metabolism in Liver Disease (Record C. and Al-Mardini H., eds), pp. 159-163. Ipswich Book, Newcastle.
33. Sourkes T. L. (1978) Tryptophan in hepatic coma. J. Neural Transm. Suppl. 14, 79-86.
34. Stone T. W. (1993) Neuropharmacology of quinolinic and kynurenic acids. Pharmacol. Rev. 45, 309-379.
35. Suyama Y. and Hirayama C. (1981) Serum indole and skatole in patients with various liver diseases. Clin. Chim. Acta 176, 203-206.
36. Vederas J. C., Schleicher E., Tsai M., and Floss H. G. (1978) Stereo-chemistry and mechanism of reactions catalyzed by tryptophanase from Escherichia coli. J. Biol. Chem. 253, 5350-5354.
37. Young S. and Lal S. (1980) CNS tryptamine metabolism in hepatic coma. J. Neural Transm. 47, 153-161.
38. Zeneroli M. L., Iuliano E., Racagni G., and Baraldi M. (1982) Metabolism and brain uptake of γ-aminobutyric acid in galactosamine-induced hepatic encephalopathy in rats. J. Neurochem. 38, 1219-1222.