HIV-1 induces human monocyte-derived macrophages to produce C3 and to fix C3 on their surface

Journal of Leukocyte Biology

Volumn 63, Issue 4, 1998, Pages 463-468

  Bajtay, Zsuzsa ^a   Kacani, Laco ^b   Erdei, Anna ^a   Dierich, Manfred P ^b  

^a EÖTVÖS LORÁND UNIVERSITY   (Hungary)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

C3 deposition; Complement activation; Interleukin 6

Indexed keywords

COMPLEMENT COMPONENT C3;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; COMPLEMENT ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPATHOGENESIS; MACROPHAGE ACTIVATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SYNTHESIS REGULATION; VIRUS CELL INTERACTION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; TRIXIS;

EID: 0031978470     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.63.4.463     Document Type: Article

References (23)

1. Balter, M. (1996) HIV's other immune-system targets: macrophages. Science 274, 1464-1465.
2. Sullivan, B. L., Knopoff, E. J., Saifuddin, M., Takefman, D. M., Saarloos, M.-N., Sha, B. E., Spear, G. T. (1996) Susceptibility of HIV-1 plasma virus to complement-mediated lysis. J. Immunol 157, 1791-1798.
3. Stoiber, H., Clivio, A., Dierich, M. P. (1997) The role of complement in HIV infection. Annu. Rev. Immunol. 15, 649-674.
4. Ebenbichler, C. F., Thielens, N. M., Vornhagen, R., Marschang, P., Arlaud, G. J., Dierich, M. P. (1991) Human immunodeficiency virus type 1 activates the classical pathway of complement by direct binding C1 through specific sites in the transmembrane glycoprotein gp41. J. Exp. Med. 174, 1417-1424.
5. Joling, P., Bakker, L. J., Van Strijp, J. A. G., Meerloo, T., De Graaf, L., Dekker, M. E. M., Goudsmit, J., Verhoef, J., Schuurman, H.-J. (1993) Binding of human immunodeficiency virus type-1 to follicular dendritic cells in vitro is complement dependent. J. Immunol. 150, 1065-1073.
6. Andrews, P. A., Zhou, W., Sacks, S. H. (1995) Tissue synthesis of complement as an immune regulator. Mol. Med. Today 1, 202-207.
7. Merrill, J. E. (1992) Cytokines and retroviruses. Clin. Immunol. Immunopathol. 64, 23-27.
8. Nakajima, K., Martinez-Maza, O., Hirano, T., Breen, E. C., Nishaman, P. G., Salazar-Gonzalez, J. F., Fahey, J. L., Kishimoto, T. (1989) Induction of IL-6 (B cell stimulatory factor-2/IFN-beta2) production by HIV. J. Immunol. 142, 531-536.
9. Merrill, J. E., Koyanagi, Y., Chen, I. S. (1989) Interleukin-1 and tumor necrosis factor alpha can be induced from mononuclear phagocytes by human immunodeficiency virus type 1 binding to the CD4 receptor. J. Virol. 63, 4404-4408.
10. Boyum, A. (1968) Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand. J. Lab. Invest. 97, 77-89.
11. Freundlich, B., Avdalovic, N. (1983) Use of gelatin/plasma coated flasks for isolating human peripheral blood monocytes. J. Immunol. Meth. 62, 31-37.
12. Di Renzo, L., De Cristofaro, M. R., Zicari, A., Viola, R., Pontieri, G., Lipari, M. (1994) IFN-γ and TNF-α cause an increased release of C3 by murine macrophages. Immunol. Lett. 42, 167-172.
13. Maison, C. M., Villiers, C. L., Colomb, M. G. (1989) Secretion, cleavage and binding of complement component C3 by the human monocytic cell line U937. Biochem. J. 261, 407-113.
14. Erdei, A., Bajtay, Z., Fabry, Z., Sim, R. B., Gergely, J. (1988) Appearance of acceptor-bound C3b on HLA-DR positive macrophages and on stimulated U937 cells; inhibition of Fc-receptors by the covalently fixed C3 fragments. Mol. Immunol. 25, 295-303.
15. Fauci, A. S. (1996) Host factors and the pathogenesis of HIV-induced disease. Nature 384, 529-534.
16. Erdei, A., Füst, G., Gergely, J. (1991) The role of C3 in the immune response. Immunol. Today 12, 332-338.
17. Erdei, A., Bajtay, Z., Kerekes, K. (1994) The role of C3 in cellular and molecular adhesion. In New Aspects of Complement Structure and Function. (A. Erdei, ed.) Austin, TX: R. G. Landes Co., 73-85.
18. Arvieux, J., Yssel, H., Colomb, M. G. (1988) Antigen-bound C3b and C4b enhance antigen-presenting cell function in activation of human T cell clones. Immunology 65, 229-235.
19. Dempsey, P. W., Allison, M. E., Akkaraju, S., Goodknow, C. C., Fearon, D. T. (1996) C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271, 348-350.
20. Ezekowitz, R. A. B., Sim, R. B., Hill, M., Gordon, S. (1983) Local opsonization by secreted macrophage complement components. J. Exp. Med. 159, 244-260.
21. Sutton, M. B. J., Strunk, R. C., Cole, F. (1986) Regulation of the synthesis of the third component of complement and factor B in cord blood monocytes by lipopolysaccharide. J. Immunol. 136, 1366-1371.
22. Hogasen, A. K. M., Hestdal, K., Abrahamsen, T. G. (1993) Granulocyte-macrophage colony stimulating factor, but not macrophage colony stimulating factor, supresses basal and lipopolysaccharide-stimulated component factor production in human monocytes. J. Immunol. 151, 3215-3224.
23. Simmons, G. D., Wilkinson, D., Reeves, J. D., Dittmar, M. T, Beddows, S., Weber, J., Carnegie, G., Desselberger, U., Gray, P. W., Weiss, R. A., Clapham, P. R (1996) Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry. J. Virol. 70, 8355-8360.