Cotransfection of second and third intracellular loop fragments inhibit angiotensin AT1a receptor activation of phospholipase C in HEK-293 cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 1, 1998, Pages 216-222

  Thompson, Joseph B ^a   Wade, Susan M ^a   Harrison, Jeffrey K ^c   Salafranca, Mina N ^c   Neubig, Richard R ^a,b,d  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1B ADRENERGIC RECEPTOR; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; INOSITOL PHOSPHATE; PHOSPHOLIPASE C;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KIDNEY CELL; NONHUMAN; PLASMID; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECEPTOR DENSITY;

ANIMALS; CELLS, CULTURED; COS CELLS; ENZYME ACTIVATION; GENETIC VECTORS; HUMANS; INOSITOL PHOSPHATES; KIDNEY; PEPTIDES; PHOSPHOLIPASE C; PROTEIN CONFORMATION; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, ANGIOTENSIN; TRANSFECTION;

EID: 0031978266     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. s by synthetic peptides corresponding to an intracellular loop of the β-adrenergic receptor. FEBS Lett 279:277-280.
2. Clapham DE and Neer EJ (1993) New roles for G-protein βγ dimers in transmembrane signalling. Nature 365:403-406.
3. Couraud PO, Delavier-Klutchko C, Durieu-Trautmann O and Strosberg AD (1981) Antibodies raised against beta-adrenergic receptors stimulate adenylate cyclase. Biochem Biophys Res Commun 99:1295-1302.
4. 2A-adrentrgic receptor alter receptor G protein coupling by distinct mechanisms. J Biol Chem 266:11025-11029.
5. Dudley DT, Panek RL, Major TC, Lu GH, Bruns RF, Klinkefus BA, Hodges JC and Weishaar RE (1990) Subclasses of angiotensin II binding sites and their functional significance. Mol Pharmacol 38:370-377.
6. Hawes BE, Luttrell LM, Exum ST and Lefkowitz RJ (1994) Inhibition of G protein-coupled receptor signalling by expression of cytoplasmic domains of the receptor. J Biol Chem 269:15776-15785.
7. Higashijima T, Uzu SD, Nakajima T and Ross EM (1988) Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins). J Biol Chem 263:6491-6494.
8. Huang RC, Dehaven RN, Cheung AH, Diehl RE, Dixon RAF and Strader CD (1990) Identification of allosteric antagonists of receptor-guanine nucleotide-binding protein interactions. Mol Pharmacol 37:304-310.
9. Johnson RM and Garrison JC (1987) Epidermal growth factor and angiotensin II stimulate formation of inositol 1,4,5-and inositol 1,3,4-triphosphate in hepatocytes. J Biol Chem 262:17285-17293.
10. Jouneaux C, Mallat A, Serradeil Le Gal C, Goldsmith P, Hanoune J and Lotersztajn S (1994) Coupling of endothelin B receptors to the calcium pump and phospholipase C via Gs and Gq in rat liver. J Biol Chem 269:1845-1851.
11. Kambayashi Y, Bardhan S, Takahashi K, Tsuzuki S, Inui H, Hamakubo T and Inagam T (1993) Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. J Biol Chem 268:24543-24546.
12. + currents involves an inhibitory GTP binding protein. Am J Physiol 267:C1389-1397.
13. Kjelsberg MA, Cotecchia S, Ostrowski J, Caron MG and Lefkowitz RJ (1992) Constitutive activation of the α IB-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation. J Biol Chem 267:1430-1433.
14. König B, Arendt A, McDowel JH, Kahlert M, Hargrave PA and Hofmann KP (1989) Three cytoplasmic loops of rhodopsin interact with transducin. Proc Natl Acad Sci USA 86:6878-6882.
15. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
16. Luttrell LM, Ostrowski J, Cotecchia S, Kendall H and Lefkowitz RJ (1993) Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. Science (Wash DC) 259:1453-1457.
17. Moro O, Lameh J, Hogger P and Sadee W (1993) J Hydrophobic amino acid in the i2 loop plays a key role in receptor-G protein coupling. J Biol Chem 268:22273-22276.
18. Munch G, Dees C, Hekman M and Palm D (1991) Multisite contacts involved in coupling of the b-adrenergic receptor with the stimulatory guanine-nucleotide binding regulatory protein. Structural and functional studies by β-receptor-site-specific peptides. Ear J Biochem 198:357-364.
19. Murphy TJ, Alexander RW, Griendling KK, Runge MS and Bernstein KE (1995) Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature (Lond) 351:233-236.
20. Neer EJ (1994) G proteins: Critical control points for transmembrane signals. Protein Sci 3:3-14.
21. 2 adrenergic receptors: Evidence for a precoupled receptor-guanine nucleotide protein complex. Biochemistry 27:2374-2384.
22. Nishimoto I, Murayama Y, Katada T, Ui M and Ogata E (1989) Possible direct linkage of insulin-like growth factor-II receptor with guanine nucleotide-binding proteins. J Biol Chem 264:14029-14038.
23. Ohnishi H, Ishido M, Shibata T, Inagami T, Murakami K and Miyazaki H (1992) The rat angiotensin II at 1A receptor couples with three different signal transduction pathways. Biochem Biophys Res Comm 186:1094-1101.
24. Ohyama K, Yamano Y, Chaki S, Kondo T and Inagami T (1992) Domain for G protein coupling in angiotensin II receptor type I: Studies by site-directed mutagenesis. Biochem Biophys Res Commun 189:677-683.
25. Okamoto T, Takeda S, Murayama Y, Ogata E and Nishimoto I (1995) Ligand-dependent G protein coupling function of amyloid transmembrane precursor. J Biol Chem 270:4205-4208.
26. Ostrowski J, Kjelsberg MA, Caron MG and Lefkowitz RJ (1992) Mutagenesis of the beta 2-adrenergic receptor: How structure elucidates function. Annu Rev Pharmacol Toxicol 32:167-183.
27. Palm D, Munch G, Dees C and Hekman M (1989) Mapping of b-adrenoceptor coupling domains to Gs-protein by site-specific synthetic peptides. FEBS Lett 254:89-93.
28. Parma J, Duprez L, Van Sande J, Cochaux P, Gervy C, Mockel J, Dumont J and Vassart G (1993) Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature (Lond) 365:649-651.
29. Pobiner BF, Northup JK, Bauer PH, Fraser ED and Garrison JC (1991) Inhibitory GTP-binding regulatory protein Gi3 can couple angiotensin II receptors to inhibition of adenylyl cyclase in hepatocytes. Mol Pharmacol 40:156-167.
30. 2-adrenergic receptor. Extending the ternary complex model. J Biol Chem 268:4625-4636.
31. Sambrook J, Fritsch EF and Maniatis T (1989) Plasmid vectors, in Molecular Cloning: A laboratory Manual. Ford N, Nolan C and Fergusson M (eds) pp 1.21-1.52, Cold Spring Harbor, NY.
32. Shenker A, Laue L, Kosugi S, Merendino JJJ, Minegishi T and Cutler GBJ (1993) A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty. Nature (Lond) 365:652-654.
33. Shibata T (1996) Identification of regions in the human angiotensin II receptor type 1 responsible for Gi and Gq coupling by mutagenesis study. Biochem Biophys Res Commun 218:383-389.
34. Shirai H, Takahashi K, Katada T and Inagami T (1995) Mapping of G protein coupling sites of the angiotensin II type 1 receptor. Hypertension 25:726-730.
35. Strader CD, Dixon RA, Cheung AH, Candelore MR, Blake AD and Sigal IS (1987) Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity. J Biol Chem 262:16439-16443.
36. Strader CD, Pickel VM, Joh TH, Strohsacker MW, Shorr RG, Lefkowitz RJ and Caron MG (1983) Antibodies to the beta-adrenergic receptor: Attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain. Proc Natl Acad Sci USA 80:1840-1844.
37. Strosberg AD (1985) Monoclonal antibodies as tools for the study of membrane receptors. Biochem Soc Trans 13:1106-1107.
38. A/B chimeras. J Biol Chem 270:10072-10078.
39. Takahasi K, Bardhan S, Kambayashi Y, Shirai H and Inagami T (1994) Protein tyrosine phosphate inhibition by angiotensin II in rat pheochromocytoma cells through type 2 receptor. AT2. Biochem Biophys Res Commun 198:60-66.
40. Taylor JM, Jacob-Mosier GG, Lawton RG, Vandort M and Neubig RR (1996) Receptor and membrane interaction sites on Gβ - a receptor-derived peptide binds to the carboxyl terminus. J Biol Chem 271:3336-3339.
41. Thompson JB, Wade SM, Salafranca MN, Harrison JK and Neubig RR (1995) The second intracellular loup of angiotensin la receptor blocks receptor-stimulated phospholipase C (PLC) activity when expressed in human 293 cells, (Abstract) FASEB J 9:A949 (5508).
42. 2-advenergic receptor i3c region. Mol Pharmacol 50:351-358.
43. Wang C, Jayadev S and Escobedo JA (1995) Identification of a domain in the angiotensin II type 1 receptor determining Gq coupling by the use of receptor chimeras. J Biol Chem 270:16677-16682.
44. s in response to muscarinic agonists, J Biol Chem 265:6219-6224.
45. Wu D, Katz A, Lee CH and Simon MI (1992) Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family. J Biol Chem 267:25798-25802.
46. ++ currents in cultured neurons by angiotensin II type la receptor peptide. Am J Physiol 273:C1040-1048.