Emergence of drug resistance during an influenza epidemic: Insights from a mathematical model

Journal of Infectious Diseases

Volumn 177, Issue 4, 1998, Pages 863-873

  Stilianakis, Nikolaos I ^b   Perelson, Alan S ^c   Hayden, Frederick G ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; RIMANTADINE;

ARTICLE; EPIDEMIC; HUMAN; INFECTION CONTROL; INFLUENZA; MATHEMATICAL MODEL; PRIORITY JOURNAL; VIRUS MUTATION; VIRUS TRANSMISSION;

EID: 0031978256     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/515246     Document Type: Article

References (8)

1. Hayden FG, Belshe RB, Clover RD, Hay AJ, Oakes MG, Soo W. Emergence and apparent transmission of rimantadine-resistant influenza A virus in families. N Engl J Med 1989;321:1696-702.
2. Mast EE, Harmon MW, Gravenstein S, et al. Emergence and possible transmission of amantadine-resistant viruses during nursing home outbreaks of influenza A (H3N2). Am J Epidemiol 1991;134:988-97.
3. Houck P, Hemphill M, LaCroix S, Hirsh D, Cox N. Amantadine-resistant influenza A in nursing homes: identification of a resistant virus prior to drug use. Arch Intern Med 1995;155:533-7.
4. Hayden FG. Amantadine and rimantadine-clinical aspects. In: Richman DD, ed. Antiviral drug resistance. Chichester, UK: John Wiley and Sons, 1996:59-77.
5. Degelau J, Somani SK, Cooper SL, Guay DRP, Crossley KB. Amantadine-resistant influenza A in a nursing facility. Arch Intern Med 1992;152: 390-2.
6. Patriarca PA, Cox NJ. Influenza pandemic preparedness plan for the United States. J Infect Dis 1997;176(suppl 1):S4-7.
7. Monto AS. Prospects for pandemic influenza control with currently available vaccines and antivirals. J Infect Dis 1997;176(suppl l):S32-7.
8. Hayden FG. Antivirals for pandemic influenza. J Infect Dis 1997;176(suppl 1):S56-61.