Palladium and nickel catalyzed hydroxycarbonylation of a steroidal bromodiene in the synthesis of episteride, a potent 5α-reductase inhibitor

Synthetic Communications

Volumn 28, Issue 9, 1998, Pages 1611-1615

  McGuire, Michael A ^a   Sorenson, Edmund ^a   Klein, Donald N ^a   Baine, Neil H ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPRISTERIDE; NICKEL; OXIDOREDUCTASE INHIBITOR; PALLADIUM;

ARTICLE; CARBOXYLATION; COMPLEX FORMATION; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROLYSIS; NONHUMAN; PROSTATE HYPERTROPHY; RELIABILITY;

EID: 0031978238     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1080/00397919808006865     Document Type: Article

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19. 4 and filtered. The solvent was removed by vacuum distillation. This yielded crude 3, which was recrystallized from boiling acetonitrile (50 mL) to yield SK&F 105657 (1.41 g, 77%) as a white crystalline solid. The product was identical to previously reported 3. 13
20. 4 and filtered. The solvent was removed under vacuum. The crude product was recrystallized from boiling acetonitrile (50 mL) to yield SK&F 105657 (1.10 g, 60%) as a white crystalline solid. The product was identical to previously reported 3. 13
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