Identification of a single nucleotide insertion polymorphism in the upstream region of the insulin promoter factor-1 gene: An association study with diabetes mellitus

Diabetologia

Volumn 41, Issue 5, 1998, Pages 603-605

  Yamada, K ^a   Yuan, X ^a   Ishiyama, S ^a   Ichikawa, F ^a   Kohno, S ^a   Shoji, S ^a   Hayashi, H ^a   Nonaka, K ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Insulin promoter factor 1; Insulin dependency; Mutation; Polymorphism

Indexed keywords

C PEPTIDE; GUANINE; INSULIN; NUCLEOTIDE;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE INSERTION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE SEQUENCE; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOSITY; HOMOZYGOTE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROMOTER REGION;

ADOLESCENT; ADULT; ALLELES; BASE SEQUENCE; C-PEPTIDE; CHILD; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENES; GENOTYPE; GUANINE NUCLEOTIDES; HETEROZYGOTE; HOMEODOMAIN PROTEINS; HOMOZYGOTE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MUTAGENESIS, INSERTIONAL; POLYMORPHISM, GENETIC; TRANS-ACTIVATORS;

EID: 0031977918     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050954     Document Type: Article

References (6)

1. Ohlsson H, Karlsson K, Edlund T (1993) IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12: 4251-4259
2. Inoue H, Riggs AC, Tanizawa Y et al. (1996) Isolation, characterization, and chromosomal mapping of the human insulin promoter factor 1 (IPF-1) gene. Diabetes 45: 789-794
3. Jonsson J, Carlsson L, Edlund T, Edlund H (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371: 606-609
4. Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Hahener JF (1997) Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nature Genetics 15: 106-110
5. Fernandes A, King LC, Guz Y, Stein R, Wright CVE, Teitelman G (1997) Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology 138: 1750-1762
6. Olson LK, Sharma A, Peshavaria M et al. (1995) Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiological glucose concentration is associated with loss of STF-1 transcription fact or expression. Proc Natl Acad Sci USA 92: 9127-9131