Antisense oligonucleotides targeting c-fos mRNA inhibit rheumatoid synovial fibroblast proliferation

Annals of the Rheumatic Diseases

Volumn 57, Issue 2, 1998, Pages 122-124

  Morita, Yoshitaka ^a   Kashihara, Naoki ^a   Yamamura, Masahiro ^a   Okamoto, Hideyuki ^a   Harada, Seishi ^a   Kawashima, Masanori ^a   Makino, Hirofumi ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; INTERLEUKIN 1; MESSENGER RNA; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;

ARTICLE; CELL PROLIFERATION; ELECTROPHORETIC MOBILITY; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIUM;

EID: 0031976639     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.57.2.122     Document Type: Article

References (16)

1. Gay S, Gay R E, Koopman W J. Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction. Ann Rheum Dis 1993;52:S39-47.
2. Greenberg M E, Ziff E B. Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature 1984; 311:433-8.
3. Angel P, Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta 1991;1072:129-57.
4. Dooley S, Herlitzka I, Hanselmann R, Ermis A, Henn W, Remberger K, et al. Constitutive expression of c-fos and c-jun, overexpression of ets-2, and reduced expression of metastasis suppression gene nm23-H1 in rheumatoid arthritis. Ann Rheum Dis 1996;55:298-304.
5. Trabandt A, Aicher W K, Gay R E, Sukhatme V P, Fassbender H-G, Gay S. Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts. Rheumatol Int 1992;12:53-9.
6. Shiozawa S, Tanaka Y, Fujita T, Tokuhisa T. Destructive arthritis without lymphocyte infiltration in H2-c-fos transgenic mice. J Immunol 1992;148:3100-4.
7. Wagner R W. Gene inhibition using antisense oligodeoxynucleotides. Nature 1994;372:333-5.
8. Morita Y, Kashihara N, Yamamura M, Okamoto H, Harada S, Maeshima Y, et al. Inhibition of rheumatoid synovial fibroblast proliferation by antisense oligonucleotides targeting proliferating cell nuclear antigen messenger RNA. Arthritis Rheum 1997;40:1292-7.
9. Okamoto H, Yamamura M, Morita Y, Harada S, Makino H, Ota Z. The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritis. Arthritis Rheum 1997;40:1096-105.
10. Schreiber H, Matthias P, Müller M M, Schaffner W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 1989;17:6419.
11. Asahara H, Fujisawa K, Kobata T, Hasunuma T, Maeda T, Asanuma M, et al. Direct evidence of high DNA binding activity of transcription factor AP-1 in rheumatoid arthritis synovium. Arthritis Rheum 1997;40:912-18.
12. Schönthal A, Herrlich P, Rahmsdorf H J, Ponta H. Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters. Cell 1988;54:325-34.
13. Shiozawa S, Shimizu K, Tanaka K, Hino K. Studies on the contribution of c-fos/AP-1 to arthritis joint destruction. J Clin Invest 1997;49:1210-16.
14. Yakubov L, Khaled Z, Zhnag L M, Truneh A, Vlassov V, Stein C A. Oligodeoxynucleotides interact with recombinant CD4 at multiple sites. J Biol Chem 1993;268: 18818-23.
15. Perez J R, Li Y, Stein C A, Majumder S, Oorschot A V, Narayanan R. Sequence-independent induction of Sp1 transcription factor activity by phosphorothioate oligodeoxynucleotides. Pro Natl Acad Sci USA 1994;91:5957-61.
16. Kashihara N, Maeshima Y, Makino H. Therapeutic Intervention in glomerulonephritis by oligunucleotides. Exp Nephrol 1997;5:126-131.