Modulation of vincristine cytotoxicity by dexverapamil in sensitive and resistant HL-60 cell lines as a function of extracellular protein binding

International Journal of Clinical Pharmacology and Therapeutics

Volumn 36, Issue 2, 1998, Pages 103-106

  Stratmann, G ^a   Harder, S ^a   Holzer D ^a   Hoffmann, W K ^a   Ottmann, O G ^a   Woodcock, B G ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEXVERAPAMIL; VINCRISTINE;

CELL GROWTH; CELL STRAIN HL 60; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; ISOTOPE LABELING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOOD; CALCIUM CHANNEL BLOCKERS; CELL DIVISION; DRUG RESISTANCE, MULTIPLE; EXTRACELLULAR MATRIX; HL-60 CELLS; HUMANS; OROSOMUCOID; P-GLYCOPROTEIN; PROTEIN BINDING; VERAPAMIL; VINCRISTINE;

EID: 0031975786     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (8)

1. 1-acid glycoprotein in wild-type and multidrug-resistant Chinese hamster ovary cell lines. Cancer Res 50: 2818-2822
2. Echizen H, Manz M, Eichelbaum M 1988 Electrophysiologic effects of dextro- and levo-verapamil on sinus node and AV node function in humans. J Cardiovasc Pharmacol 12: 543-546
3. Gross A, Heuer B, Eichelbaum M 1988 Stereoselective protein binding of verapamil enantiomers. Biochem Pharmacol 37: 4623-4627
4. Keefe D, Yee Y-G, Kates R 1981 Verapamil protein binding in patients and in normal subjects. Clin Pharmacol Ther 29: 21-26
5. Kremer J, Wilting J, Janssen L 1988 Drug binding to human alpha-1-acid glycoprotein in health and disease. Pharmacol Rev 40: 1-47
6. Sur P, Matsua Y, Otani T, Minovade J 1991 Modulation of methotrexat cytotoxicity with natural interferon upon human leukemia cell-line HL-60. Oncology 48: 469-473
7. Tsuruo T, Lida H, Tsukagoshi S, Sakurai Y 1983 Potentiation of vincristine and adriamycin effects in human hemopoietic tumor cell lines by calcium antagonists and calmodulin inhibitors. Cancer Res 43: 2267-2272
8. 1-acid glycoprotein. Eur J Cancer 29: 559