Different pharmacokinetics of (4R)-hexahydro-7,7-dimethyl-6-oxo-1, 2,5-(3-14C)dithiazocine-4-carboxylic acid between the fasting and non-fasting rat: Role of intestinal microorganisms

Xenobiotica

Volumn 28, Issue 1, 1998, Pages 53-62

  Tsuji, F ^a   Morikawa, N ^a   Takashina, H ^a  

^a SANTEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DISULFIDE; HEXAHYDRO 7,7 DIMETHYL 6 OXO 1,2,5 DITHIAZOCINE 4 CARBOXYLIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DRUG METABOLISM; INTESTINE; INTESTINE FLORA; METABOLITE; MICROORGANISM; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; RAT;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; AZOCINES; CARBON RADIOISOTOPES; CECUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISULFIDES; FASTING; FECES; INTESTINES; MALE; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0031975706     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982598239759     Document Type: Article

References (21)

1. BARTH, C., SLADEK, M. and DECKER, K., 1971, The subcellular distribution of short-chain fatty acyl-CoA synthetase activity in rat tissues. Biochimica et Biophysica Acta, 248, 24-33.
2. CUMMINGS, J. H., 1981, Short chain fatty acids in the human colon. Gut, 22, 763-779.
3. GIBSON, S. A. W., MCFARLAN, C., HAY, S. and MACFARLANE, G. T., 1989, Significance of microflora in proteolysis in the colon. Applied and Environmental Microbiology, 55, 679-683.
4. HARAGUCHI, Y., SASAKI, H., NAKAMURA, J. and SHIBASAKI, J., 1989, Formation of salicylic acid from salicyluric acid by intestinal microflora - effects of fasting and pretreatment with antibiotics. Journal of Pharmacobio-Dynamics, 12, S72.
5. ISHIDA, N., NAKATA, K., TANAKA, M., TAKASE, K. and MITA, S., 1991, The protective effects of (4R)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide, on chemically-induced acute liver injury. Japanese Journal of Pharmacology, 55, 275-278.
6. LARSEN, G. L. and BAKKE, J. E., 1983, Metabolism of mercapturic acid-pathway metabolites of 2-chloroN-isopropylacetanilide (propachlor) by gastrointestinal bacteria. Xenobiotica, 13, 115-126.
7. NAKATA, K., SASANO, M., MATSUNAGA, K., TANAKA, M. and MITA, S., 1991, Protective effect of (4R)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithiazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide compound, on immunology induced liver injuries in mice. Archives Internationales de Pharmacodynamie et de Therapie, 309, 170-184.
8. PERRETT, D., SNEDDON, W. and STEPHENS, A. D., 1976, Studies on D-penicillamine metabolism in cystinuria and rheumatoid arthritis: isolation of S-methyl-D-pencillamine. Biochemical Pharmacology, 25, 259-264.
9. ROWLAND, I. R., MALLETT, A. K. and WISE, A., 1985, The effect of diet on the mammalian gut flora and its metabolic activities. CRC Critical Reviews in Toxicology, 16, 31-103.
10. SASANO, M., NAKATA, K. and MITA, S., 1991, Modulatory effects of SA3443 on interleukin-2 and interferon-γ production in human peripheral blood mononuclear cells. International Journal of Immunotherapy, 7, 117-122.
11. SAWAMOTO, T., KUROSAKI, Y., KIMURA, T. and NAKAYAMA, T., 1996. Pharmacokinetics of acetaminophen sulfate after oral administration in rats: analysis of plasma profiles exhibiting a nonlinear second peak. Biological and Pharmaceutical Bulletin, 19, 77-82.
12. SHIMIZU, K., AMAGAYA, S. and OGIHARA, Y., 1985, Structural transformation of saikosaponins by gastric juice and intestinal flora. Journal of Pharmacobio-Dynamics, 8, 718-725.
13. STRUGALA, G. J., RAUWS, A. G. and ELBERS, R., 1986, Intestinal first pass metabolism of amygdalin in the rat in vitro. Biochemical Pharmacology, 35, 2123-2128.
14. SUZUKI, S., TOMISAWA, H., ICHIHARA, S., FUKAZAWA, H. and TATEISHI, M., 1982, A C=S bond cleavage enzyme of cysteine conjugates in intestinal microorganisms. Biochemical Pharmacology, 31, 2137-2140.
15. TAKEDA, S., ISHIHARA, K., WAKUI, Y., AMAGAYA, S., MARUNO, M., AKAO, T. and KOBASHI, K., 1996, Bioavailability study of glycyrrhetic acid after oral administration of glycyrrhizin in rats: relevance to the intestinal bacterial hydrolysis. Journal of Pharmacy and Pharmacology, 48, 902-905.
16. TANAKA, M., NAKATA, K., TAKASE, K. and MITA, S., 1991, The protective effects of (4R)-hexahydro-7,7-dimethyl-6-oxo-1,2,5-dithioazocine-4-carboxylic acid (SA3443), a novel cyclic disulfide compound, on acetaminophen-induced liver injury. Folia Pharmacologica Japonica, 97, 191-198.
17. TATEISHI, M., SUZUKI, S. and SHIMIZU, H., 1978, Cysteine conjugate β-lyase in rat liver. Journal of Biological Chemistry, 253, 8854-8859.
18. TOMISAWA, H., SUZUKI, S., ICHIHARA, S., FUKAZAWA, H. and TATEISHI, M., 1984, Purification and characterization of C-S lyase from Fusobacterium varium. Journal of Biological Chemistry, 259, 2588-2593.
19. TOZAKI, H., EMI, Y., HORISAKA, E., FUJITA, T., YAMAMOTO, A. and MURANISHI, S., 1995, Metabolism of peptide drugs by the microorganisms in rat cecal contents. Biological and Pharmaceutical Bulletin, 18, 929-931.
20. WATANABE, K., YAMASHITA, S., FURUNO, K., KAWASAKI, H. and GOMITA, Y., 1995, Metabolism of omeprazole by gut flora in rats. Journal of Pharmaceutical Sciences, 84, 516-517.
21. YANG, M. G., MANOHARAN, K. and MICKELSEN, O., 1970, Nutrition contribution of volatile fatty acids from the cecum of rats. Journal of Nutrition, 100, 545-550.