A structural model of picornavirus leader proteinases based on papain and bleomycin hydrolase

Journal of General Virology

Volumn 79, Issue 2, 1998, Pages 301-307

  Skern, Tim ^a   Fita, Ignasi ^b   Guarné, Alba ^b  

^a UNIVERSITY OF VIENNA   (Austria)

^b DEPT OF ENVIRONMENTAL CHEMISTRY   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; HYDROLASE; PAPAIN; PROTEINASE; VIRUS ENZYME;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME STRUCTURE; FOOT AND MOUTH DISEASE VIRUS; GENETIC PROCEDURES; NONHUMAN; PICORNAVIRUS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE; RHINOVIRUS; SEQUENCE ANALYSIS; STEREOCHEMISTRY;

APHTHOVIRUS; EQUIDAE; EQUINE RHINITIS A VIRUS; EQUINE RHINOVIRUS; EUKARYOTA; FOOT-AND-MOUTH DISEASE VIRUS; PICORNAVIRIDAE; RHINOVIRUS; RNA VIRUSES;

EID: 0031975650     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-79-2-301     Document Type: Article

References (21)

1. Allaire, M., Chernaia, M., Malcolm, B. A. & James, M. N. G. (1994). Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsinlike serine proteinases. Nature 369, 72-76.
2. Bazan, J. F. & Fletterick, R. J. (1989). Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications. Proceedings of the National Academy of Sciences, USA 85, 7872-7876.
3. Berti, P. & Storer, A. C. (1995). Alignment/phylogeny of the papain superfamily of cysteine proteinases. Journal of Molecular Biology 246, 273-283.
4. Cao, X., Bergmann, I. E., Füllkrug, R. & Beck, E. (1995). Functional analysis of the two alternative translation initiation sites of foot-and-mouth disease virus. Journal of Virology 69, 560-563.
5. Devaney, M. A., Vakharia, V. N., Lloyd, R. E., Ehrenfeld, E. & Grubman, M. J. (1988). Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex. Journal of Virology 62, 4407-4409.
6. Gorbalenya, A. E., Donchenko, A. P., Blinov, V. M. & Koonin, E. V. (1989). Cysteine proteases of positive strand RNA viruses and chymotrypsin-like serine proteases. A distinct protein superfamily with a common structural fold. FEBS Letters 243, 103-114.
7. Gorbalenya, A. E., Koonin, E. V. & Lai, M. M. (1991). Putative papain-related thiol proteases of positive-strand RNA viruses. Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, alpha- and coronaviruses. FEBS Letters 288, 201-205.
8. Guarné, A., Kirchweger, R., Verdaguer, R., Liebig, H.-D., Blaas, D., Skern, T. & Fita, I. (1996). Crystallization and preliminary X-ray diffraction studies of the Lb proteinase of foot-and-mouth disease virus. Protein Science 5, 1931-1933.
9. Joshua-Tor, L., Xu, H. E., Johnston, S. A. & Rees, D. C. (1995). Crystal structure of a conserved protease that binds DNA: the bleomycin hydrolase, Gal6. Science 269, 945-950.
10. Kamphuis, I. G., Kalk, K. H., Swarte, M. B. A. & Drenth, J. (1984). Structure of papain refined at 1·65 Å resolution. Journal of Molecular Biology 179, 233-256.
11. Kirchweger, R., Ziegler, E., Lamphear, B. J., Waters, D., Liebig, H. D., Sommergruber, W., Sobrino, F., Hohenadl, C., Blaas, D., Rhoads, R. E. & Skern, T. (1994). Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4γ. Journal of Virology 68, 5677-5684.
12. Kleina, L. G. & Grubman, M. J. (1992). Antiviral effects of a thiol protease inhibitor on foot-and-mouth disease virus. Journal of Virology 66, 7168-7175.
13. Kraulis, P. J. (1991). MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. Journal of Applied Crystallography 24, 946-950.
14. Lamphear, B. J., Kirchweger, G., Skern, T. & Rhoads, R. R. (1995). Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Journal of Biological Chemistry 270, 21975-21983.
15. Matthews, D. A., Smith, W. W., Ferre, R. A., Condon, B., Budahazi, G., Sisson, W., Villafranca, J. E., Janson, C. A., McElroy, H. E., Gribskov, C. L. & Worland, S. (1994). Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein. Cell 77, 761-771.
16. Piccone, M. E., Zellner, M., Kumosinski, T. F., Mason, P. W. & Grubman, M. J. (1995). Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus. Journal of Virology 69, 4950-4956.
17. Roberts, P. J. & Belsham, G. J. (1995). Identification of critical amino acids within the foot-and-mouth disease virus leader protein, a cysteine protease. Virology 213, 140-146.
18. Rost, B. (1996). PHD: predicting one-dimensional protein structure by profile based neural networks. Methods in Enzymology 266, 525-539.
19. Rost, B. & Sander, C. (1993). Prediction of protein structure at better than 70% accuracy. Journal of Molecular Biology 232, 584-599.
20. Sangar, D. V., Newton, S. E., Rowlands, D. J. & Clarke, B. E. (1987). All foot and mouth disease virus serotypes initiate protein synthesis at two separate AUGs. Nucleic Acids Research 15, 3305-3315.
21. Wutz, G., Auer, H., Nowotny, N., Grosse, B., Skern, T. & Kuechler, E. (1996). Equine rhinovirus serotypes 1 and 2: relationship to each other and to aphthoviruses and cardioviruses. Journal of General Virology 77, 1719-1730.