Flow-mediated regulation of G-protein expression in cocultured vascular smooth muscle and endothelial cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 1, 1998, Pages 75-83

  Redmond, Eileen M ^a,b   Cahill, Paul A ^a   Sitzmann, James V ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Flow; G proteins; Shear stress; Vascular endothelial cells; Vascular smooth muscle

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENYLATE CYCLASE; GUANINE NUCLEOTIDE BINDING PROTEIN; INDOMETACIN; NITRIC OXIDE SYNTHASE; PERTUSSIS TOXIN; PROSTACYCLIN; PROSTAGLANDIN SYNTHASE;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ARTICLE; CATTLE; COCULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; FLOW; IMMUNOBLOTTING; MALE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; SHEAR STRESS; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

EID: 0031974210     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.1.75     Document Type: Article

References (10)

1. Davies P. Flow mediated endothelial mechanotransduction. Physiol Rev. 1995;75:519-560.
2. Osol G. Mechanotransduction by vascular smooth muscle. J Vasc Res. 1995;32:275-292.
3. Skalak TC, Price RJ. The role of mechanical stresses in microvascular remodeling. Microcirculation. 1996;3:143-165.
4. Frangos JA, Eskin SG, McIntire LV, Ives CL. Flow effects on prostacyclin production by cultured human endothelial cells. Science. 1985;227:1477-1479.
5. Ranjan V, Xiao Z, Diamond SL. Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress. Am J Physiol. 1995;269: H550-H555.
6. Kuchan MJ, Frangos JA. Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells. Am J Physiol. 1993;264:H150-H156.
7. Lan Q, Mercurius KO, Davies PF. Stimulation of transcription factors NFκB and AP-1 in endothelial cells subjected to shear stress. Biochem Biophys Res Commun. 1994;201:950-956.
8. Awolesi MA, Sessa WC, Sumpio BE. Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells. J Clin Invest. 1995;96:1449-1454.
9. Cheng JJ, Wung BS, Chao WJ, Wang DL. Cyclic strain enhances adhesion of monocytes to endothelial cells by increasing intracellular adhesion molecule-1 expression. Hypertension. 1996;28:386-391.
10. Cheng JJ, Chao WJ, Wung BS, Wang DL. Cyclic strain-induced plasminogen activator inhibitor-1 (PAI-1) release from endothelial cells involves reactive oxygen species. Biochem Biophys Res Commun. 1996;225:100-105.