Mini- and full-length dystrophin gene transfer induces the recovery of nitric oxide synthase at the sarcolemma of mdx4(cv) skeletal muscle fibers

Gene Therapy

Volumn 5, Issue 1, 1998, Pages 59-64

  Decrouy, A ^a   Renaud, J M ^a   Lunde, J A ^a   Dickson, G ^b   Jasmin, B J ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Duchenne muscular dystrophy; Dystrophin; Gene therapy; mdx; nNOS; Skeletal muscles

Indexed keywords

DYSTROPHIN; MUTANT PROTEIN; NITRIC OXIDE SYNTHASE; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DUCHENNE MUSCULAR DYSTROPHY; ENZYME LOCALIZATION; GENE TRANSFER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOLEMMA; SKELETAL MUSCLE; TIBIALIS ANTERIOR MUSCLE;

ANIMALIA;

EID: 0031973686     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300553     Document Type: Article

References (36)

1. Matsumara K, Campbell KP. Dystrophin-glycoprotein complex: its role in the molecular pathogenesis of muscular dystrophies. Musc Nerve 1994, 17: 2-15.
2. Ahn AH, Kunkel LM. The structural and functional diversity of dystrophin. Nat Genet 1993; 3: 283-291.
3. Worton R. Muscular dystrophies: diseases of the dystrophinglycoprotein complex. Science 1995, 270: 819-822.
4. Meuke A, Jockush H. Decreased osmotic stability of dystrophinless muscle cells from the mdx mouse. Nature 1991; 349: 69-71.
5. Weller B, Karpati G, Carpenter S. Dystrophin-deficient mdx muscle fibres are preferentially vulnerable to necrosis induced by experimental lengthening contractions. J Neurol Sci 1990; 100: 9-13.
6. Moens P, Baatsen PHWW, Maréchal G Increased susceptibility of EDL muscles from mdx mice to damage induced by contractions with stretch. J Musc Res Cell Mot 1993; 14: 446-451.
7. Petrof BJ et al. Dystrophin protects the sarcolemma from stresses developed during muscle contraction. Proc Natl Acad Sci USA 1993; 90: 3710-3714.
8. 6v diaphragm muscle fibres increases sarcolemunal stability. Gene Therapy 1997; 4: 401-408.
9. England SB et al. Very mild muscular dystrophy associated with the deletion of 46% of dystrophin. Nature 1990; 343: 180-182.
10. Nakane M et al. Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett 1993; 316: 175-180.
11. Kobzik L, Reid MB, Bredt DS, Stamler JS. Nitric oxide in skeletal muscle. Nature 1994; 372: 546-548.
12. Mészáros LG, Minarovic I, Zahradnikova A. Inhibition of the skeletal muscle ryanodine receptor calcium release channel by nitric oxide. FEBS Lett 1996; 380: 49-52.
13. Brenman JE et al. Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy. Cell 1995; 82: 743-752.
14. Brenman JE et al. Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α1-syntrophin mediated by PDZ domains. Cell 1996; 84: 757-767.
15. Grozdanovic Z, Gosztonyi G, Gossrau R. Nitric oxide synthase I (NOS-I) is deficient in the sarcolemma of striated muscle fibres in patients with Duchenne muscular dystrophy, suggesting an association with dystrophin. Acta Histochem 1996; 98: 61-69.
16. Deconinck N et al. Functional protection of dystrophic mouse (mdx) muscles after adenovirus-mediated transfer of a dystrophin mmigene. Proc Natl Acad Sci USA 1996; 93: 3570-3574.
17. Schuman EM, Madison DV. Nitric oxide and synaptic function. Annu Rev Neurosci 1994; 17: 153-183.
18. Bredt DS, Snyder SH. Nitric oxide: a physiologic messenger molecule. Annu Rev Biochem 1994; 63: 175-195.
19. Danko I, Chapman V, Wolff JA. The frequency of revertants in mdx mouse genetic models for Duchenne muscular dystrophy. Pediatr Res 1992; 32: 128-131.
20. Stedman HH et al. The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy. Nature 1991; 352: 536-539.
21. Dupont-Versteegden EE, McCarter RJ. Differential expression of muscular dystrophy in diaphragm versus hindlimb muscles of mdx mice. Musc Nerve 1992; 15: 1105-1110
22. Boland B, Himpens B, Denef JF, Gillis JM. Site-dependent pathological differences in smooth muscles and skeletal muscles of the adult mdx mouse. Muse Nerve 1995; 18: 649-657.
23. Dunckley MG, Wells DJ, Walsh FS, Dickson G. Direct retroviral-mediated transfer of a dystrophin minigene into mdx mouse muscle in vivo. Hum Mol Genet 1993; 2: 717-723.
24. Chao DS et al. Selective loss of sarcolemmal nitric oxide synthase in Becker muscular dystrophy. J Exp Med 1996; 184: 608-618
25. Grozdanovic Z et al. Absence of nitric oxide synthase 1 despite the presence of dystrophin complex in human striated muscle. Histochem J 1997; 29: 97-104.
26. Acsadi G et al. Human dystrophin expression in mdx mice after intramuscular injection of DNA constructs. Nature 1991; 352: 815-818.
27. Phelps SF et al. Expression of full-length and truncated dystrophin mini-genes in transgenic mdx mice. Hum Mol Genet 1995; 4: 1251-1258.
28. Cox GA et al. Overexpression of dystrophin in transgenic mdx mice eliminates dystrophic symptoms without toxicity. Nature 1993; 364: 725-729.
29. Im WB et al. Differential expression of dystrophin isoforms in strain of mdx mice with different mutations. Hum Mol Genet 1996; 5: 1149-1153.
30. Legay C, Mankal FA, Massoulié J, Jasmin BJ. Expression and targeting of GPI-linked and asymmetric forms of acetylcholinesterase in skeletal muscle cells. Mol Biol Cell 1996; 7: 538a.
31. Jones G et al. Induction by agrin of ectopic and functional post-synaptic-like membrane in innervated muscle. Proc Natl Acad Sci USA 1997; 94: 2654-2659.
32. d'Albis A, Couteaux R, Janmot C, Mira JC Myosin isofortn transitions in regeneration of fast and slow muscles during postnatal development of the rat. Dev Biol 1989; 135: 320-325.
33. Wells DJ. Improved gene transfer by direct plasmid injection associated with regeneration in mouse skeletal muscle. FEBS Lett 1993; 332: 179-182.
34. Davis HL et al. Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle. Hum Gene Ther 1993; 4: 733-740.
35. Davis HL, Jasmin BJ. Direct gene transfer into mouse diaphragm. FEBS Lett 1993; 333: 146-150.
36. Cartaud A et al. Localization of dystrophin and dystrophin-related protein at the electromotor synapse and neuromuscular junction in Torpedo marmorata. Neurosci 1992; 48: 995-1003.