Functional expression and localization of vascular endothelial growth factor and its receptors in the human epididymis

Biology of Reproduction

Volumn 58, Issue 1, 1998, Pages 160-168

  Ergun S ^a   Luttmer, W ^a   Fiedler, W ^a   Holstein, A F ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN TYROSINE KINASE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

AGED; ARTICLE; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; EPIDIDYMIS; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LYMPH VESSEL; MALE; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CAPILLARIES; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; EPIDIDYMIS; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOKINES; MALE; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0031973546     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod58.1.160     Document Type: Article

References (45)

1. Morita J. Some observations on the fine structure of the human ductuli efferentes testis. Arch Histol Jpn 1966; 26:341-365.
2. Holstein AF. Morphologische Studien am Nebenhoden des Menschen. Zwanglose Abhandlungen aus dem Gebiet der normalen und pathologischen Anatomie 20. Berlin, Heidelberg, New York: Springer; 1969.
3. Robaire B, Hermo L. Efferent ducts, epididymidis, and vas deferens: structure, functions, and their regulation. In: Knobil E, Neill J (eds.), The Physiology of Reproduction. New York: Raven Press; 1988: 999-1080.
4. Saitho K, Terada T, Matekeyama S. A morphocological study of the efferent ducts of the human epididymis. Int J Androl 1990; 13:369-376.
5. Yeung CH, Cooper TG, Bergmann M, Schulze H. Organization of tubules in the human caput epididymidis and the ultrastructure of their epithelia. Am J Anat 1991; 191:261-279.
6. Reid BL, Cleland KW. The structure and function of the epididymis. I. The histology of the rat epididymis. Aust J Zool 1957; 5:223-246.
7. Orgebin-Crist MC, Olsen GE. Epididymal sperm maturation. In: Courot M (ed.), The Male in Farm Animal Reproduction. Amsterdam: Martinus Nijhoff; 1984: 80-102.
8. Blandau RJ, Rumery RE. The relationship of swimming movements of epididymal spermatozoa to their fertilizing capacity. Fertil Steril 1964; 15:571-579.
9. Setchell BP. Anatomy, vasculature, innervation, and fluids of the male reproductive tract. In: Knobil E, Neill J (eds.), The Physiology of Reproduction. New York: Raven; 1994: 1065-1175.
10. Suzuki F. Microvasculature of the mouse testis and excurrent duct system. Am J Anat 1982; 163:309-325.
11. Abe K, Takano H, Ito T. Mikrovasculature of the mouse epididymis, with special reference to fenestrated capillaries localized in the initial segment. Anat Rec 1984; 209:209-218.
12. Senger DR, Peruzzi CA, Feder J, Dvorak HF. A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines. Cancer Res 1986; 46:5629-5632.
13. Senger DR, Connolly DT, Van De Water D, Feder J, Dvorak HF. Purification and N-terminal amino acid sequence of guinea pig tumor secreted vascular permeability factor. Cancer Res 1990; 50:1774-1778.
14. Roberts WG, Palade GE. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci 1995; 108:2369-2379.
15. Ferrara N, Henzel WJ. Pituitary follicular cells secrete a novel heparin binding growth factor special for vascular endothelial cells. Biochem Biophys Res Commun 1989; 161:851-858.
16. Ferrara N, Houck K, Jakeman I, Leung D. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 1992; 13:18-32.
17. Brown LF, Berse B, Tognazzi K, Manseau EJ, Van De Water L, Senoer D, Dvorak HF, Rosen S. Vascular permeability factor mRNA and protein expression in human kidney. Kidney Int 1992; 42:1457-1461.
18. Fava RA, Olsen NJ, Spencer-Green G, Yeo KT, Berse B, Jackman RJ, Senger D, Dvorak HF, Brown LF. Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J Exp Med 1994; 180:341-346.
19. Koch A, Harlow L, Haines G, Arnento E, Unemori E, Wong W, Pope R, Ferrara N. Vascular endothelial growth factor. A cytokine modulating endothelial functions in rheumatoid arthritis. J Immunol 1994; 152:4149-4156.
20. Berkman RA, Merrill MJ, Reinhold WC, Monacci WT, Saxena A, Clark WC, Robertson JT, Ali IU, Oldfield EH. Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms. J Clin Invest 1993; 91:153-159.
21. Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE, Nguyen HV, Aiello LM, Ferrara N, King GL. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331:1480-1487.
22. Breier G, Albrecht U, Sterrer S, Risau W. Expression of vascular endothelial growth factor during embryogenic angiogenesis and endothelial cell differentiation. Development 1992; 114:521-532.
23. Millauer B, Wizigmann-Voos S, Schnürch H, Martinez R, Møller NPH, Risau W, Ullrich A. A high affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 1993; 72:835-846.
24. Tischer E, Mitchel B, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing J Biol Chem 1991; 266:11947-11954.
25. Quinn TP, Peters KG, De VC, Ferrara N, Williams LT. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc Natl Acad Sci USA 1993; 90:7533-7537.
26. De Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. The fms-tyrosine kinase, a receptor for vascular endothelial growth factor. Science 1992; 255:989-991.
27. Terman BI, Dougher-Vermazen M, Carrion ME, Dimitrov D, Armellino DC, Gospodarowicz D, Bohlen P. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor Biochem Biophys Res Commun 1992; 187:1579-1586.
28. Takagi H, King GL, Aiello LP. Identification and characterization of vascular endothelial growth factor receptor (Flt) in bovine retinal pericytes. Diabetes 1996; 45:1016-1023.
29. Takahashi T, Shirasawa T, Miyake K, Yahagi Y, Maruyama N, Kasahara N, Kawamura T, Matsumura O, Mitarai T, Sakai O. Protein tyrosine kinases expressed in glomeruli and cultured glomerular cells: Flt-1 and VEGF expression in renal mesangial cells. Biochem Biophys Res Commun 1995; 209:218-226.
30. Ergün S, Kilic N, Fiedler W, Mukhopadhyay A. Vascular endothelial growth factor (VEGF) and its receptors in the normal human testicular tissue. Mol Cell Endocrinol 1997; 131:9-20.
31. Klagsbrun M, D'Amore PA. Vascular endothelial growth factor and its receptors. Cytokine Growth Factor Rev 1996; 7:259-270.
32. Fiedler W, Graeven U, Ergün S, Verago S, Kilic N, Stockschläder M, Hossfeld DK. Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia. Blood 1997; 89:1870-1875.
33. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227:680.
34. Davidoff MS, Schulze W. Combination of the peroxidase anti-peroxidase (PAP)- and avidin-biotin-peroxidase complex (ABC)-techniques: an amplification alternative in immunocytochemical staining. Histochemistry 1990; 93:531-536.
35. Itoh Z, Akiva K, Nakamura S, Miguno M, Nakamura Y, Sugimoto T. Application of coupled oxidation reaction to electron microscopic demonstration of horseradish peroxidase: cobalt glucose oxidase method. Brain Res 1979; 75:341-346.
36. Záborszky L, Léránth C. Simultaneous ultrastructural demonstration of retrogradely transported horseradish peroxidase and choline acetyltransferase immunoreactivity. Histochemistry 1985; 82:529-537.
37. Simionescu N, Simionescu M. The cardiovascular system. In: Weiss L (ed.), Cell and Tissue Biology. Baltimore, Munich: Urban und Schwarzenberg; 1988: 355-398.
38. Schnittler HJ, Wilke A, Gress TH, Suttorp N, Drenckhahn D. Role of actin and myosin in the control of paracellular permeability in pig, rat and human vascular endothelium. J Physiol (Lond) 1990; 431:379-401.
39. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86:353-364.
40. Parra RO, Boullier J, Mehan DJ. Malignant tumor of the colon metastatic to the epididymis as a first sign of recurrence of colon cancer. MO Med 1992; 89:298-300.
41. Clauss M, Gerlach M, Gerlach H, Brett J, Wang F, Familletti PC, Pan YCE, Olander JV, Connolly DT, Stern D. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte migration. J Exp Med 1990; 172:1535-1545.
42. Yoshida A, Anand-Apte B, Zetter BR. Differential endothelial migration and proliferation to basic fibroblast growth factor and vascular endothelial growth factor. Growth Factors 1996; 13:57-64.
43. Olson GE, Hinton BJ. Regional differences in luminal fluid polypeptides of the rat testis and epididymis revealed by two-dimensional gel electrophoresis. J Androl 1985; 6:20-34.
44. Brooks DE. Secretion of proteins and glycoproteins by the rat epididymis: regional differences, androgen dependence and effects of protease inhibitors, procaine and tunicamycin. Biol Reprod 1981; 25:1099-1117.
45. Krull N, Ivell R, Osterhoff C, Kirchhoff C. Region-specific variation of gene expression in the human epididymis as revealed by in situ hybridization with tissue specific cDNAs. Mol Reprod Dev 1993; 34:16-24.