Cotinine: Effects with and without nicotine

Psychopharmacology

Volumn 135, Issue 2, 1998, Pages 141-150

  Hatsukami, Dorothy ^a   Pentel, Paul R ^b   Jensen, Joni ^a   Nelson, David ^a   Allen, Sharon S ^a   Goldman, Anne ^a   Rafael, Donna ^c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b HENNEPIN COUNTY MEDICAL CENTER   (United States)

^c MINNEAPOLIS MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Cotinine; Nicotine patch; Tobacco withdrawal

Indexed keywords

COTININE; NICOTINE; PLACEBO;

ABSTINENCE; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG WITHDRAWAL; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; METABOLITE; MOOD; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PERFORMANCE; PRIORITY JOURNAL; SMOKING CESSATION; TOBACCO; TRANSDERMAL DRUG ADMINISTRATION; WITHDRAWAL SYNDROME;

ADMINISTRATION, TOPICAL; ADULT; AFFECT; BLOOD PRESSURE; COTININE; DRUG THERAPY, COMBINATION; FEMALE; HEART RATE; HUMANS; MALE; MIDDLE AGED; NICOTINE; NICOTINIC AGONISTS; SMOKING CESSATION; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0031973237     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050495     Document Type: Article

References (52)

1. Abood LG, Reynolds DT, Booth H, Bidlack JM (1981) Sites and mechanisms for nicotine's action in the brain. Neurosci Biobehav Rev 5:479-486
2. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington, DC
3. Andersson K, Jansson A, Kuylenstierna F, Eneroth P (1993) Nicotine and its major metabolite cotinine have different effects on aldosterone and prolactin serum levels in the normal male rat. Eur Pharmacol Environ Toxicol Pharmacol Sect 8:305-313
4. Barbieri RL, Gochberg J, Ryan KT (1986) Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro. Clin Invest 77:1727-1733.
5. Barbieri RL, York CM, Cherry ML, Ryan KT (1987) The effects of nicotine, cotinine, and anabasine on rat adrenal 11β-hydroxylase and 21-hydroxylase. Steroid Biochem 28:25-28
6. Beckett AH, Gorrod JW, Jenner P (1972) A possible relationship between pKa1 and lipid solubility and the amounts excreted in urine of some tobacco alkaloids given to man. Pharm Pharmacol 24:115-120
7. Benowitz NL (1983) The use of biologic fluid samples in assessing tobacco smoke consumption. In: Grabowski J, Bell CS (eds) Measurement in the analysis and treatment of smoking behavior. NIDA Res Monogr 48, Washington, DC, pp 6 26
8. Benowitz NL, Kuyt F, Jacob P, Jones RT, Osman AL (1983) Cotinine disposition and effects. Clin Pharmacol Ther 34:604-611
9. Borzelleca JF, Bowman ER, McKennis H (1962) Studies on the respiratory and cardiovascular effects of ( - )-cotinine. Pharmacol Exp Ther 137:313-318
10. Bowman ER, McKennis H (1962) Studies on the metabolism of ( - )-cotinine in the human. Pharmacol Exp Ther 135:306-311
11. Bowman ER, McKennis H (1963) ( - )-Cotinine. In: Brown BG (ed) Biochemical preparations. Wiley, New York, pp 36-39
12. Chahine R, Calderone A, Navarro-Delmasure C (1990) The in vitro effects of nicotine and cotinine on prostacyclin and thromboxane biosynthesis. Prostaglandins Leukot Essent Fatty Acids 40:261-266
13. Chahine R, Aftimos G, Wainberg MC, Navarro-Delmasure C, Abou Khalil K, Chahoud B (1996) Cotinine modulates the cardiovascular effects of nicotine. Med Sci Res 24:21-23
14. Crooks PA, Teng L, Li M, Bardo MT, Wilkins LH, Dwoskin LP (1997) Cotinine pharmacology: brain uptake and metabolism, effects on dopamine release and lack of behavioral sensitization after chronic administration to rats. In: Harris L (ed) Problems of drug dependence 1996: Proceedings of the 58th Annual Scientific Meeting. The College on Problems of Drug Dependence. NIDA Res Monogr 174, Rockville MD, p 203
15. Curvall M, Elwin CE, Kazemi-Vala E, Warholm C, Enzell DR (1990) The pharmacokinetics of cotinine in plasma and saliva from non-smoking healthy volunteers. Eur Clin Pharmacol 38:281-287
16. DeClercq M, Truhaut R (1963) Recherches sur le metabolisme du tryptophane chez le rat soumis a l'intoxication chronique par la cotinine. Etude de l'elimination urinaire et dosage dans le cerveau et les intestins de certains derives inoliques. Bull Soc Chim Biol (Paris) 45:995-1001
17. DeSchepper PJ, Van Hecken A, Daenens P, Van Rossum JM (1987) Kinetics of cotinine after oral and intravenous administration to man. Eur Clin Pharmacol 31:583-588
18. Diller L, Ben-Yishay Y, Gerstman LJ et al. (1974) Studies in cognition and rehabilitation in hemiplegia. Rehabilitation Monograph 50. New York University Medical Center, Institute of Rehabilitation Medicine, New York
19. Dominiak P, Fuch G, VonToth S, Grobecker H (1985) Effects of nicotine and its major metabolites on blood pressure in anesthetized rats. Klin Wochenschr 63:90-92
20. Erenmemisoglu A, Tekol Y (1994) Do nicotine metabolites have an effect on pain perception? Antinociceptive effect of cotinine in mice. Pharmazie 49:374-375
21. Essman WB (1973) Nicotine-related neurochemical changes: some implications for motivational mechanisms and differences. In: Dunn WL Jr (ed) Smoking behavior: motives and incentives. VH Winston, Washington, DC, pp 51-65
22. Fagerström K-O (1978) Measuring degree of physical dependence to tobacco smoking with reference to individualization of treatment. Addict Behav 3:235-241
23. Fuxe K, Everett BJ, Hökfelt T (1979) On the action of nicotine and cotinine on central 5-hydroxytryptamine neurons. Pharmacol Biochem Behav 10:671-677
24. Goldberg SR, Risner ME, Stolerman IP, Reavill C, Garcha HS (1989) Nicotine and some related compounds: effects on schedule-controlled behavior and discriminative properties in rats. Psychopharmacology 97:265-302
25. Hatsukami D, Fletcher L, Morgan S, Keenan R, Amble P (1989) The effects of varying cigarette deprivation on cognitive and performance tasks. J Subst Abuse 1:407-416
26. Hatsukami DK, Grillo M, Pentel PR, Oncken C, Bliss R (1997) Safety of cotinine in humans: physiologic, subjective and cognitive effects. Pharmacol Biochem Behav 57: 643-650
27. Heishman SJ, Taylor RC, Henningfield JE (1994) Nicotine and smoking: a review of effects on human performance. Exp Clin Psychopharmacol 2:345-395
28. Hughes JR, Hatsukami DK (1986) Signs and symptoms of tobacco withdrawal. Arch Gen Psychiatry 43:289-294
29. Hughes JR, Higgins ST, Hatsukami D (1990) Effects of abstinence from tobacco. A critical review. In: Kozlowski LT, Annis HM, Cappell HD, Glaser FB, Goodstadt MS, Israel Y, Kalant H, Sellers EM, Vinigilis ER (eds) Research advances in alcohol and drug problems, vol 10. Plenum Press, New York
30. Hughes JR, Gust SW, Skoog K, Keenan RM, Fenwick JW (1991) Symptoms of tobacco withdrawal: a replication and extension. Arch Gen Psychiatry 48:52-59
31. Jacob P III, Wilson M, Benowitz NL (1981) Improved gas chromatographic method for the determination of nicotine and cotinine in biologic fluids. J Chromatogr 222:61-70
32. Jorenby DE, Hatsukami DK, Smith SS, Fiore MC, Allen S, Jensen J, Baker TB (1996) Transdermal nicotine replacement reduces tobacco withdrawal symptoms. Psychopharmacology 128: 130-138
33. Keenan RM, Hatsukami DK, Pentel PR, Thompson T, Grillo MA (1994) Pharmacodynamic effects of cotinine in abstinent cigarette smokers. Clin Pharmacol Ther 55:581-590
34. Kim KS, Borzelleca JF, Bowman ER, McKennis H (1964) Effect of cotinine and other nicotine metabolites in vitro on duodenum and ileum segments. Fed Proc 23:330
35. Kim KS, Borzelleca JF, Bowman ER, McKennis H (1968) Effects of some nicotine metabolites and related compounds on isolated smooth muscle. Pharmacol Exp Ther 161:59-69
36. McKennis H, Turnbull LB, Bowman ER (1963) N-Methylation of nicotine and cotinine in vivo. Biol Chem 238:719-723
37. McNair DM, Lorr M, Droppleman LF (1971) Manual for the profile of mood states. Educational and Industrial Testing Service, San Diego
38. Meikle AW, Liu XH, Taylor GN, Stringham JD (1988) Nicotine and cotinine effects on 3-alpha-hydroxysteroid dehydrogenase in canine prostate. Life Sci 43:1845-1850
39. Patterson TR, Stringham JD, Meikle AW (1990) Nicotine and cotinine inhibit steroidogenesis in mouse Leydig cells. Life Sci 46:265-272
40. Risner ME, Goldberg SR, Prada JA, Cone EJ (1985) Effects of nicotine, cocaine, and some of their metabolites on schedule-controlled responding by beagle dogs and squirrel monkeys. Pharmacol Exp Ther 234:113-119
41. Rosecrans JA, Chance WT (1977) Cholinergic and non-cholinergic aspects of the discriminative stimulus properties of nicotine. In: Lal H (ed) Discriminative stimulus properties of drugs. Plenum Press, New York, pp 155-185
42. Scherer G, Jarczyk L, Heller WD, Biber A, Neurath GB, Adlkofer F (1988) Pharmacokinetics of nicotine, cotinine and 3′-hydroxycotinine in cigarette smokers. Klin Wochenschr 66 [Suppl XI]: 5 11
43. Smith A (1968) The Symbol Digit Modalities test: a neuropsychological test for economic screening of learning and other cerebral disorders. Learn Disord 3:91-93
44. Smith TL, Russell GB, Mosberg AT (1994) Long-term systemic hemodynamic effects of cotinine in rats. Cardiovasc Pharmacol 23:458-465
45. Stroop JR (1935) Studies of interference in serial verbal reactions. Exp Psychol 18:643-661
46. Takada K, Swedberg MD, Goldberg SR, Katz JL (1989) Discriminative stimulus effects of intravenous 1-nicotine and nicotine analogs or metabolites in squirrel monkeys. Psychopharmacology 99:208-212
47. Tiffany ST, Drobes DT (1991) The development and initial validation of a questionnaire on smoking urges. Br Addict 86:1467-1476
48. Transdermal Nicotine Study Group (1991) Transdermal nicotine for smoking cessation. JAMA 266:3133-3138
49. US Department of Health and Human Services (1988) The health consequences of smoking: nicotine addiction. A report of the Surgeon General. DHHS Publication No. (CDC) 88-8406
50. Yamamoto K-I, Domino EF (1965) Nicotine-induced EEG and behavioral arousal. Int Neuropharmacol 4:359-373
51. Yeh J, Barbieri RJ, Friedman AJ (1989) Nicotine and cotinine inhibit rat testes androgen biosynthesis in vitro. Steroid Biochem 33:627-630
52. Zevin S, Jacob P, Benowitz N (1997) Cotinine effects on nicotine metabolism. Clin Pharmacol Ther 61:649-654