Pharmacological mechanism of topical lodoxamide treatment in vernal keratoconjunctivitis: A flow-cytometric study

Ophthalmic Research

Volumn 30, Issue 1, 1998, Pages 37-43

  Avunduk, Avni Murat ^a   Avunduk, Mustafa Cihat ^b   Dayanir, Volkan ^c   Tekelioǧlu, Yavuz ^a   Dayioǧlu, Yavuz Selim ^a  

^a KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

^b SELCUK UNIVERSITY   (Turkey)

^c Air Force Hospital   (Turkey)

Author keywords

Flow cytometry; Helper T lymphocyte; Lodoxamide treatment; T helper 2 lymphocyte; Vernal keratoconjunctivitis

Indexed keywords

HISTAMINE RELEASE INHIBITOR; LODOXAMIDE TROMETAMOL;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG MECHANISM; FLOW CYTOMETRY; HELPER CELL; HUMAN; KERATOCONJUNCTIVITIS; LACRIMAL FLUID; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; TOPICAL DRUG ADMINISTRATION; VERNAL CONJUNCTIVITIS;

ADMINISTRATION, TOPICAL; ADOLESCENT; ADULT; CHILD; CONJUNCTIVITIS, ALLERGIC; FLOW CYTOMETRY; FOLLOW-UP STUDIES; HUMANS; LYMPHOCYTE COUNT; OPHTHALMIC SOLUTIONS; OXAMIC ACID; TEARS; TH1 CELLS; TH2 CELLS; TREATMENT OUTCOME;

EID: 0031972748     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055452     Document Type: Article

References (25)

1. Allansmith MR: Vernal conjunctivitis; in Tasman W, Jaeger EA (eds): Duane's Clinical Ophthalmology, rev. Philadelphia, Harper & Row, 1991, vol 4.
2. Buckley RJ: Vernal keratoconjunctivitis. Int Ophthalmol 1988;28: 303-306.
3. Rice NSC, Jones BR: Vernal keratoconjunctivitis: An allergic disease of the eyes of children. Clin Allergy 1973;3:269-272.
4. Abelson MB, Udell IJ, Allansmith MR: Allergic and toxic reactions; in Albert DM, Jacobiec FA (eds): Principles and Practise of Ophthalmology: Clinical Practise. Philadelphia, Saunders, 1994, pp 77-100.
5. Santos CI, Huang AJ, Abelson MB, Foster CS, Friedlander M, McCulley JP: Efficacy of lodoxamide 0.1% ophthalmic solution in resolving corneal epitheliopathy associated with vernal keratoconjunctivitis. Am J Ophthalmol 1994;117:488-497.
6. Lodoxamide for vernal keratoconjunctivitis. Med Lett Drug Ther 1994;18:26.
7. Abelson MB, Schaefer K: Conjunctivitis of allergic origin: Immunologic mechanisms and current approaches to therapy. Surv Ophthalmol 1993;38(suppl):115-127.
8. Abbas AK, Lichtman HA, Pober JS: Cellular and Molecular Immunology. Philadelphia, Saunders, 1995, pp 283-284.
9. Peltz G: A role for CD4+ T cell subsets producing a selective pattern of lymphokines in the pathogenesis of human chronic inflammatory and allergic diseases. Immunol Rev 1991;123:23-35.
10. Bonini S, Bonini S: IgE and non-IgE mechanisms in ocular allergy. Ann Allergy 1993;71:196-198.
11. Maggi EJ, Biswas P, Del Prete G: Accumulation of Th2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis. J Immunol 1991;146:1169-1174.
12. Johnson RL: Flow cytometry: From research to clinical applications. Clin Lab Med 1993;13:831-838.
13. Coon JS, Weinstein RS: Diagnostic Flow Cytometry. Baltimore, Williams & Wilkins, 1991.
14. Norn MS: The conjunctival fluid: Its height, volume, density of cells, and flow. Acta Ophthalmol 1966;44: 212-216.
15. Avunduk AM, Çetinkaya K, Kapicioǧlu Z: Comparison of T helper/T suppressor ratios in aqueous humour and blood samples by flow cytometric analysis. Ophthalmologica 1997;211:84-86.
16. Avunduk AM, Avunduk MC, Çetinkaya K, Dayioǧlu YS: Flow cytometric analysis of tears in patients with chronic allergic conjunctivitis. Jpn J Ophthalmol 1997;41:67-70.
17. Yanni JM, Weimer LK, Glaser RL, Lang LS, Robertson SM, Spellman JM: Effect of lodoxamide on in vitro and in vivo conjunctival immediate hypersensitivity responses in rats. Int Arch Allergy Immunol 1993; 101:102-106.
18. Hingorani M, Lighman S: Therapeutic options in ocular allergic diseases. Drugs 1995;50:208-221.
19. Cerqueti PM, Ricca V, Tosca MA, Buscaglia S, Ciprandi G: Lodoxamide treatment of allergic conjunctivitis. Int Arch Allergy Immunol 1994; 105:185-189.
20. Jaanus SD: Anti-inflammatory drugs; in Bartlett JD, Jaanus SD (eds): Clinical Ocular Pharmacology. Boston, Butterworth, 1984, p 164.
21. Gonzales JP, Brogden RN: Nedocromil sodium: A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of reversible obstructive airway disease. Drugs 1987;34:560-577.
22. Foreman JC: Substance P and calcitonin gene-related peptide: Effects on mast cells and human skin. Int Arch Allergy Appl Immunol 1987; 82:366.
23. Bonini S, Bonini S, Lamblase A: Vernal conjunctivitis: A model of 5q cytokine gene cluster disease. Int Arch Allergy Immunol 1995;107: 95-98.
24. Montan PG, Biberfeld PS, Scheynius A: IgE, IgE receptors and other immunocytochemical markers in atopic and non-atopic patients with vernal conjunctivitis. Ophthalmology 1995;102:725-732.
25. Fusishima H, Takeuchi T, Shinozaki N: Measurement of IL-4 in tears of patients with seasonal allergic conjunctivitis and vernal keratoconjunctivitis. Clin Exp Immunol 1995; 102:395-398.