Comparative bioavailability of two tablet formulations of ranitidine hydrochloride in healthy volunteers

International Journal of Clinical Pharmacology and Therapeutics

Volumn 36, Issue 5, 1998, Pages 270-274

  Bawazir, S A ^a   Wafik Gouda, M ^a   El Sayed, Y M ^a   Al Khamis, K I ^a   Al Yamani, M J ^a   Niazy, E M ^b   Al Rashood, K A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b Tabuk Pharmaceutical Mfg Company   (Saudi Arabia)

Author keywords

Comparative bioavailability; Healthy volunteers; Ranid; Ranitidine; Zantac

Indexed keywords

HISTAMINE H2 RECEPTOR ANTAGONIST; RANITIDINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; RANDOMIZED CONTROLLED TRIAL;

ADULT; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; FASTING; HISTAMINE H2 ANTAGONISTS; HUMANS; MALE; MIDDLE AGED; RANITIDINE; THERAPEUTIC EQUIVALENCY;

EID: 0031972249     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Brogden RN, Carmin AA, Heel RC 1982 Ranitidine. A review of its pharmacology and therapeutic use in peptic ulcer disease and other allied diseases. Drugs 24: 267-303
2. Grag DC, Weidler DJ, Eshelman FN 1983 Ranitidine bioavailability and kinetics in normal male subjects. Clin Pharmacol Ther 33: 445-452
3. Grag DC, Eshelman FN 1985 Pharmacokinetics of ranitidine following oral administration with ascending doses and with multiple-fixed doses. J Clin Pharmacol 25: 434-443
4. Grant SM, Langtry HD, Brogden RN 1989 Ranitidine: uptake review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in peptic ulcer disease and other allied diseases. Drugs 37: 801-870
5. Hauschke D, Steinijans VW, Diletti E 1990 A distribution-free procedure for the statistical analysis of bioequivalence studies. Int J Clin Pharmacol Ther Toxicol 28: 72-78
6. Physician's Desk Reference 1994 48th edn, Medical Economic Company, Montvale, pp 1019-1021
7. Schuirmann DJ 1987 A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability. J Pharmacokin Biopharm 15: 657-680
8. Shim CK, Hong JS 1989 Inter-and intrasubject variations of ranitidine pharmacokinetics after oral administration to normal male subjects. J Pharm Sci 78: 990-994
9. Vanhecken AM, Tjandramage TB, Mullie A, Verbesselt R, Deschepper PJ 1982 Ranitidine: Single dose pharmacokinetics and absolute bioavailability in man. Br J Clin Pharmacol 14: 195-200
10. 2 receptor antagonist. Gut 21: 187-191