Overexpression of MDM2, p53, and NCAM proteins in human radiation- induced skin ulcers

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 17, Issue 2, 1998, Pages 125-127

  Zhao, Po ^a   Wang, Dewen ^b   Gao, Yabing ^b   Yang, Zhixiang ^b   Li, Xiaoying ^a  

^a Chinese General Hospital   (China)

^b BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Chronic skin ulcer; Oncogene; Radiation

Indexed keywords

GENE PRODUCT; NERVE CELL ADHESION MOLECULE; ONCOPROTEIN; PROTEIN P53;

ARTICLE; CLINICAL ARTICLE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION INJURY; SKIN ULCER; TUMOR SUPPRESSOR GENE;

GENE EXPRESSION; GENES, TUMOR SUPPRESSOR; HUMANS; NEURAL CELL ADHESION MOLECULES; NUCLEAR PROTEINS; ONCOGENES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RADIATION INJURIES; SKIN ULCER; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031971797     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 1992; 358:80-83.
2. Patel K, Rossell RJ, Bourne S, Moore SE, Walsh FS, Kemshead JT. Monoclonal antibody UJ13A recognizes the neural cell adhesion molecule (NCAM). Int J Cancer 1989; 44:1062-1068.
3. Jin L, Hemperly JJ, Lloyd RV. Expression of neural cell adhesion molecule in normal and neoplastic human neuroendocrine tissues. Am J Pathol 1991; 138:961-969.
4. Po Z, Yang Z, Wang DW, Gao Y, Li XY, Li G. Overexpression of c-erbB-2 and p21 oncoproteins in human radiation-induced skin ulcers. J Environ Pathol Toxicol Oncol 1995; 14:21-23.
5. Shi SR, Key ME, Kalra KL. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J Histochem Cytochem 1991; 39:741-748.
6. Kovar H, Auinger A, Jug G, Aryee D, Zoubek A, Salzer-Kuntschik M, Gadner H. Narrow spectrum of infrequent p53 mutations and absence of MDM2 amplification in Ewing tumors. Oncogene 1993; 8:2683-2690.