TP53 genetic alterations in head-and-neck carcinomas from Brazil

International Journal of Cancer

Volumn 76, Issue 1, 1998, Pages 13-18

  Nagai, Maria A ^a   Miracca, Elisabete C ^a   Yamamoto, Lidia ^a   Moura, Ricardo P ^b   Simpson, Andrew J G ^c   Kowalski, Luiz P ^b   Brentani, Ricardo R ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b A C CAMARGO CANCER CENTER   (Brazil)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; DNA SEQUENCE; FAMILY HISTORY; FEMALE; GENE DELETION; GENE INSERTION; GENE MUTATION; HEAD AND NECK CANCER; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MARKER GENE; NUCLEIC ACID BASE SUBSTITUTION; PATHOGENESIS; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ALCOHOL DRINKING; BRAZIL; CARCINOMA, SQUAMOUS CELL; FEMALE; FRAMESHIFT MUTATION; GENES, P53; HEAD AND NECK NEOPLASMS; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MUTATION; SEQUENCE DELETION; SMOKING;

EID: 0031971038     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19980330)76:1<13::AID-IJC3>3.0.CO;2-0     Document Type: Article

References (19)

1. AHOMADEGBE, J.C., BARROIS, M., FOGEL, S., LE BIHAN, M.L., DOLC-RASY, S., DUVILLARD, P., ARMAND, J.P. and RIOU, G., High incidence of p53 alterations (mutations, deletions, over-expression) in head-and-neck primary tumors and metastases: absence of correlation with clinical outcome. Frequent protein over-expression in normal epithelium and in early non-invasive lesions. Oncogene, 10, 1217-1227 (1995).
2. BOYLE, J.O., HAKIM, J., KOCH, W., VAN DER RIET, P., HRUBAN, R.H., ROA, R.A., CORREO, R., EBY, Y.J., RUPPERT, M. and SIDRANSKY, D., The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Res., 53, 4477-1480 (1993).
3. CHO, Y., GORINA, S., JEFFREY, P.D. and PAVLETICH, N.P., Crystal structure of a p53-tumor-suppressor-DNA complex: understanding tumorigenic mutations. Science, 265, 346-355 (1994).
4. CHUNG, K.Y., MUKHOPADHYAY, T. KIM, J. CASSON, A., RO, J.Y., GOEPFERT, H., HONG, W.K. and ROTH, J.A., Discordant p536-gene mutations in primary head-and-neck cancers and corresponding second primary cancers of the upper aerodigestive tract. Cancer Res., 53, 1676-1683 (1993).
5. DITTMER, D., PATI, S., ZAMBETTI, G., CHU, S., TERESKY, A.K., MOORE, M., FINLAY, C. and LEVINE, A.J., Gain of function mutations in p53. Nature Genet., 4, 42-46 (1993).
6. EL-NAGGAR, A.K., LAI, S., LUNA, M.A., ZHOU, X-D., WEBER, R.S., GOEPFERT, H. and BATSAKIS, J.G., Sequential p55-mutation analysis of pre-invasive and invasive head-and-neck squamous carcinoma. Int. J. Cancer (Pred. Oncol.), 64, 196-201 (1995).
7. EYFJORD, J.E., THORLACIUS, S., STEINARSDOTTIR, M., VALGARDSDOTTIR, R., OGMUNDSDOTTIR, H.M. and ANAMTHAWAT-JONSSON, K., p53 abnormalities and genomic instability in primary human breast carcinomas. Cancer Res., 55, 646-651 (1995).
8. FINLAY, C.A., HINDS, P.W., TAN, T.-H., ELIYAHU, D., OREN, D. and LEVINE, A.J., Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol. cell. Biol. 8, 531-539 (1988).
9. FRANCO, E.L., Estimativas de incidência de concerna Estado de São Paulo. Fundação Oncocentro de São Paulo, São Paulo (1990).
10. GREENBLATT, M.S., BENNET, W.P., HOLLSTEIN, M.and HARRIS, C.C., Mutations in the p53 tumor-suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54, 4855-1878 (1994).
11. HOLLSTEIN, M., SHOMER, B., GREENBLATT, M., SOUSSI, T., HOVIG, E., MONTESANO, R.and HARRIS, C.C., Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation. Nucleic Acids Res., 21, 141-146 (1996).
12. JONES, M.H. and NAKAMURA, Y. Detection of loss of heterozygosity at the human TP53 locus using a dinucleotide repeat. Genes, Chromosomes Cancer, 5, 89-90 (1992).
13. LAZARUS, P., GAREWAL, H.S., SCIUBBA, J., ZWIEBEL, N., FAIR, A., SCHAEFER, S. and RICHIE, J.P.JR., A low incidence of p53 mutations in pre-malignant lesions of the oral cavity from non-tobacco users. Int. J. Cancer, 60, 458-463 (1995).
14. LEVINE, A.J., p53, the cellular gatekeeper for growth and division. Cell, 88, 323-331 (1997).
15. MURAKAMI, Y., HAYASHI, K. and SEKIYA, T., Detection of aberrations of the p53 alleles and the gene transcript in human tumor cell lines by single-strand conformation polymorphism analysis. Cancer Res., 51, 3356-3361 (1991).
16. RAYBAUD-DIOGÈNE, H., TÉTU, B., MORENCY, R., FORTIN, A., and MONTEIL, R.A., p53 over-expression in head-and-neck squamous-cell carcinoma: review of the literature. Oral. Oncol. Europ. J. Cancer, 32B 143-149 (1996).
17. SPITZ, M.R., Epidemiology and risk factors for head-and-neck cancer. Semin. Oncology, 21, 282-288 (1994).
18. YIN, Y. TAINSKI, M.A., BISCHOFF, F.Z., STRONG, L.C. and WAHL, G.M., Wild-type p53 restores cell-cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell, 70, 937-948 (1992).
19. ZARIWALA, M., SCHMID, S., PFALTZ, M., OHGAKI, H., KLEIHUES, P.and SCHAFER, R., p53 mutations in oropharyngeal carcinomas: a comparison of solitary and multiple primary tumours and lymph-node metastases. Int. J. Cancer, 56, 807-811 (1994).