Carbohydrate malabsorption following acarbose administration

Diabetic Medicine

Volumn 15, Issue 5, 1998, Pages 393-397

  Sobajima, H ^a   Mori, M ^a   Niwa, T ^a   Muramatsu, M ^b   Sugimoto, Y ^b   Kato, K ^b   Naruse, S ^c   Kondo, T ^c   Hayakawa, T ^c  

^a OGAKI MUNICIPAL HOSPITAL   (Japan)

^b Department of Internal Medicine   (Japan)

^c NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Acarbose; Breath hydrogen; Carbohydrate malabsorption; Gastrointestinal symptoms; Glycaemic control

Indexed keywords

ACARBOSE; CARBOHYDRATE; GLUCOSE; HEMOGLOBIN A1C;

ADULT; AGED; ARTICLE; CARBOHYDRATE ABSORPTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE HOMEOSTASIS; HUMAN; HYDROGEN BREATH TEST; INTESTINE ABSORPTION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS;

ACARBOSE; ADOLESCENT; ADULT; AGED; BREATH TESTS; DIABETES MELLITUS, TYPE 2; DIETARY CARBOHYDRATES; ENZYME INHIBITORS; FEMALE; HUMANS; HYDROGEN; HYPOGLYCEMIC AGENTS; INTESTINAL ABSORPTION; MALABSORPTION SYNDROMES; MALE; TRISACCHARIDES;

EID: 0031969865     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9136(199805)15:5<393::AID-DIA597>3.0.CO;2-K     Document Type: Article

References (24)

1. Schmidt DD, Frommer W, Junge B, Müller L, Wingender W, Truscheit E. α-Glucosidase inhibitors. New complex oligosaccharides of microbial origin. Naturwissenschaften 1977; 64: 535-536.
2. Caspary WF, Graf S. Inhibition of human intestinal α-glucosidehydrolases by a new complex oligosaccharide. Res Exp Med (Berl) 1979; 175: 1-6.
3. Suehiro I, Otsuki M, Yamasaki T, Ohki A, Sakamoto C, Yuu H, et al. Effect of α-glucosidase inhibitor on human pancreatic and salivary α-amylase. Clin Chem Acta 1981; 117: 145-152.
4. Puls W, Keup U, Krause HP, Thomas G, Hoffmeister F. Glucosidase inhibition: a new approach to the treatment of diabetes, obesity, and hyperlipoproteinaemia. Naturwissenschaften 1977; 64: 536-537.
5. Hayakawa T, Noda A, Kondo T, Okumura N. Effects of acarbose, an α-glucosidase inhibitor (BAY g 5421), on orally loaded glucose, maltose and sucrose and on blood glucose control in non-insulin dependent diabetics. Nagoya J Med Sci 1984; 47: 35-41.
6. Baron AD, Eckel RH, Schmeiser L, Kolterman OG. The effect of short-term α-glucosidase inhibition on carbohydrate and lipid metabolism in type II (noninsulin-dependent) diabetics. Metabolism 1987; 36: 409-415.
7. Caspary WF. Sucrose malabsorption in man after ingestion of α-glucosidehydrolase inhibitor. Lancet 1978; 1: 1231-1233.
8. Calloway DH. Respiratory hydrogen and methane as affected by consumption of gas-forming foods. Gastroenterology 1966; 51: 383-389.
9. Levitt MD. Production and excretion of hydrogen gas in man. N Engl J Med 1969; 281: 122-127.
10. 2) excretion to detect carbohydrate malabsorption. J Lab Clin Med 1970; 75: 937-945.
11. Jenkins DJA, Taylor RH, Goff DV, Fielden H, Misiewicz JJ, Sarson DL, et al. Scope and specificity of acarbose in slowing carbohydrate absorption in man. Diabetes 1981; 30: 951-954.
12. Carulli N, Salvioli GF, Manenti F. Absorption of lactulose in man. Digestion 1972; 6: 139-145.
13. 2) concentrations to quantity carbohydrate malabsorption by means of lactulose standards. Gut 1990; 31: 37-42.
14. Peters AL, Davidson MB. Effects of various enteral feeding products on postprandial blood glucose response in patients with type I diabetes. J Parent Enteral Natr 1992; 16: 69-74.
15. Kondo T, Liu F, Toda Y. Milk is a useful test meal for measurement of small bowel transit time. J Gastroenterol 1994; 29: 715-720.
16. American Diabetes Association. Nutritional recommendations and principles for individuals with diabetes mellitus: 1986. Diabetes Care 1987; 10: 126-132.
17. Hyams JS. Sorbitol intolerance: an unappreciated cause of functional gastrointestinal complaints. Gastroenterology 1983; 84: 30-33.
18. Kolars JC, Levitt MD, Aouji M, Savaiano DA. Yogurt -an autodigesting source of lactose. N Engl J Med 1984; 310: 1-3.
19. 2 excretion after ingestion of complex carbohydrates. Gastroenterology 1987; 92: 383-389.
20. Christopher NL, Bayless TM. Role of the small bowel and colon in lactose-induced diarrhea. Gastroenterology 1971; 60: 845-852.
21. Cummings JH. Quantitating short chain fatty acid production in humans. In: Binder HJ, Cummings J, Soergel K, eds. Short Chain Fatty Acids. Dordrecht: Kluwer Academic Publishers, 1994: 11-19.
22. Wisker E, Feldheim W. Energy value of fermentation. In: Binder HJ, Cummings J, Soergel K, eds. Short Chain Fatty Acids. Dordrecht: Kluwer Academic Publishers, 1994: 20-28.
23. Sakamoto N, Shibata M, Hotta N, Kakuta H, Tomita A, Tsuchida I, et al. Clinical study on BAY g 5421 (acarbose) for non-insulin-dependent diabetes mellitus. Jpn Pharmacol Ther 1989; 17: 633-649.
24. Maruhama Y, Nagasaki A, Kanazawa Y, Hirakawa H, Goto Y, Hishiyama H, et al. Effect of a glucoside-hydrolase inhibitor (BAY g 5421) on serum lipids, lipoproteins and bile acids, fecal tat and bacterial flora, and intestinal gas production in hyperlipidemic patients. Tohoku J Exp Med 1980; 132: 453-462.