Characterization of a human foamy virus 170-kilodalton Env-Bet fusion protein generated by alternative splicing

Journal of Virology

Volumn 72, Issue 5, 1998, Pages 4088-4094

  Lindemann, Dirk ^a   Rethwilm, Axel ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; MESSENGER RNA; VIRUS ENVELOPE PROTEIN; VIRUS GLYCOPROTEIN;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; CELL STRAIN BHK; CONTROLLED STUDY; ENVELOPE GENE; HUMORAL IMMUNITY; MOLECULAR CLONING; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RADIOIMMUNOPRECIPITATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPUMA VIRUS; VIRUS CAPSID; VIRUS PARTICLE;

EID: 0031969427     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.5.4088-4094.1998     Document Type: Article

References (38)

1. Baunach, G., B. Maurer, H. Hahn, M. Kranz, and A. Rethwilm. 1993. Functional analysis of human foamy virus accessory reading frames. J. Virol. 67:5411-5418.
2. Benko, D. M., S. Schwartz, G. N. Paviakis, and B. K. Felber. 1990. A novel human immunodeficiency virus type 1 protein, Tev, shares sequences with Tat, Env, and Rev proteins. J. Virol. 64:2505-2518.
3. Bieniasz, P. D., O. Ertwein, A. Aguzzi, A. Rethwilm, and M. O. McClure. 1997. Gene transfer using replication-defective human foamy virus vectors. Virology 235:65-72.
4. Bieniasz, P. D., A. Rethwilm, R. Pitman, M. D. Daniel, I. Chrystie, and M. O. McClure. 1995. A comparative study of higher primate foamy viruses, including a new virus from a gorilla. Virology 207:217-228.
5. Du Bridge, R. B., P. Tang, H. C. Hsia, P. M. Leong, J. H. Miller, and M. P. Calos. 1987. Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. Mol. Cell. Biol. 7:379-387.
6. Enssle, J., I. Jordan, B. Mauer, and A. Rethwilm. 1996. Foamy virus reverse transcriptase is expressed independently from the gag protein. Proc. Natl. Acad. Sci. USA 93:4137-4141.
7. Fischer, N., M. Heinkelein, D. Lindemann, J. Enssle, C. Baum, E. Werder, H. Zentgraf, J. G. Müller, and A. Rethwilm. 1998. Foamy virus particle formation. J. Virol. 72:1610-1615.
8. Furtado, M. R., R. Balachandran, P. Gupta, and S. M. Wolinsky. 1991. Analysis of alternatively spliced human immunodeficiency virus type-1 mRNA species, one of which encodes a novel tat-env fusion protein. Virology 185:258-270.
9. Giron, M. L., F. Rozain, M. C. Debons-Guillemin, M. Canivet, J. Peries, and R. Emanoil-Ravier. 1993. Human foamy virus polypeptides: identification of env and bel gene products. J. Virol. 67:3596-3600.
10. Goepfert, P. A., K. L. Shaw, G. D. Ritter, Jr., and M. J. Mulligan. 1997. A sorting motif localizes the foamy virus glycoprotein to the endoplasmic reticulum. J. Virol. 71:778-784.
11. Goepfert, P. A., G. Wang, and M. J. Mulligan. 1995. Identification of an ER retrieval signal in a retroviral glycoprotein. Cell 82:543-544.
12. Green, M. R. 1986. Pre-mRNA splicing. Annu. Rev. Genet. 20:671-708.
13. Guatelli, J. C., T. R. Gingeras, and D. D. Richman. 1990. Alternative splice acceptor utilization during human immunodeficiency virus type 1 infection of cultured cells. J. Virol. 64:4093-4098.
14. Hahn, H., G. Baunach, S. Bräutigam, A. Mergia, D. Neumann-Haefelin, M. D. Daniel, M. O. McClure, and A. Rethwilm. 1994. Reactivity of primate sera to foamy virus Gag and Bet proteins. J. Gen. Virol. 75:2635-2644.
15. Hammes, S. R., E. P. Dixon, M. H. Malim, B. R. Cullen, and W. C. Greene. 1989. Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor. Proc. Natl. Acad. Sci. USA 86:9549-9553.
16. He, F., W. S. Blair, J. Fukushima, and B. R. Cullen. 1996. The human foamy virus Bel-1 transcription factor is a sequence-specific DNA binding protein. J. Virol. 70:3902-3908.
17. Keller, A., K. M. Partin, M. Löchelt, H. Bannert, R. M. Flügel, and B. R. Cullen. 1991. Characterization of the transcriptional trans activator of human foamy retrovirus. J. Virol. 65:2589-2594.
18. Kestler, H. W. D., D. J. Ringler, K. Mori, D. L. Panicali, P. K. Sehgal, M. D. Daniel, and R. C. Desrosiers. 1991. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651-662.
19. Kim, S., K. Ikeuchi, R. Byrn, J. Groopman, and D. Baltimore. 1989. Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 86:9544-9548.
20. Lehrmann, H., D. Lindemann, S. Bräutigam, and A. Rethwilm. Expression of foamy virus envelope proteins by recombinant baculoviruses and generation of protein-specific antisera. Submitted for publication.
21. Lindemann, D., M. Bock, M. Schweizer, and A. Rethwilm. 1997. Efficient pseudotyping of murine leukemia virus particles with chimeric human foamy virus envelope proteins. J. Virol. 71:4815-4820.
22. Löchelt, M., R. M. Flügel, and M. Aboud. 1994. The human foamy virus internal promoter directs the expression of the functional Bel 1 transactivator and Bet protein early after infection. J. Virol. 68:638-645.
23. Löchelt, M., W. Muranyi, and R. M. Flügel. 1993. Human foamy virus genome possesses an internal, Bel-1-dependent and functional promoter. Proc. Natl. Acad. Sci. USA 90:7317-7321.
24. Mergia, A., K. E. Shaw, E. Pratt Lowe, P. A. Barry, and P. A. Luciw. 1991. Identification of the simian foamy virus transcriptional transactivator gene (taf). J. Virol. 65:2903-2909.
25. Moebes, A., J. Enssle, P. D. Bieniasz, M. Heinkelein, D. Lindemann, M. Bock, M. O. McClure, and A. Rethwilm. 1997. Human foamy virus reverse transcription that occurs late in the viral replication cycle. J. Virol. 71:7305-7311.
26. Montell, C., E. F. Fisher, M. H. Caruthers, and A. J. Berk. 1982. Resolving the functions of overlapping viral genes by site-specific mutagenesis at a mRNA splice site. Nature 295:380-384.
27. Muranyi, W., and R. M. Flügel. 1991. Analysis of splicing patterns of human spumaretrovirus by polymerase chain reaction reveals complex RNA structures. J. Virol. 65:727-735.
28. 60Co gamma rays. Int. J. Cancer 35:275-280.
29. Netzer, K. O., A. Rethwilm, B. Maurer, and V. ter Meulen. 1990. Identification of the major immunogenic structural proteins of human foamy virus. J. Gen. Virol. 71:1237-1241.
30. Parren, W. H., D. R. Burton, and Q. J. Sattentau. 1997. HIV-1 antibody - debris or virion? Nat. Med. 3:366-367.
31. Rethwilm, A., O. Erlwein, G. Baunach, B. Maurer, and V. ter Meulen. 1991. The transcriptional transactivator of human foamy virus maps to the bel 1 genomic region. Proc. Natl. Acad. Sci. USA 88:941-945.
32. Saib, A., J. Peries, and H. d. The. 1993. A defective human foamy provirus generated by pregenome splicing. EMBO J. 12:4439-4444.
33. Salfeld, J., H. G. Göttlinger, R. A. Sia, R. E. Park, J. G. Sodroski, and W. A. Haseltine. 1990. A tripartite HIV-1 tat-env-rev fusion protein. EMBO J. 9:965-970.
34. Schmidt, M., S. Niewiesk, J. Heeney, A. Aguzzi, and A. Rethwilm. 1997. Mouse model to study the replication of primate foamy viruses. J. Gen. Virol. 78:1929-1933.
35. Schmidt, M., and A. Rethwilm. 1995. Replicating foamy virus-based vectors directing high level expression of foreign genes. Virology 210:167-178.
36. Weiss, R. A. 1996. Foamy viruses bubble on. Nature 380:201.
37. Yu, S. F., D. N. Baldwin, S. R. Gwynn, S. Yendapalli, and M. L. Linial. 1996. Human foamy virus replication: a pathway distinct from that of retroviruses and hepadnaviruses. Science 271:1579-1582.
38. Zou, J. X., and P. A. Luciw. 1996. The transcriptional transactivator of simian foamy virus 1 binds to a DNA target element in the viral internal promoter. Proc. Natl. Acad. Sci. USA 93:326-330.