The epidemiology of Epstein-Barr virus-associated human cancers

Gann Monographs on Cancer Research

Volumn 45, Issue , 1998, Pages 51-74

  Levin, Lynn I ^a   Levine, Paul H ^b  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BURKITT LYMPHOMA; EPSTEIN BARR VIRUS; HODGKIN DISEASE; HUMAN; INFECTIOUS MONONUCLEOSIS; MALIGNANT TRANSFORMATION; NASOPHARYNX CARCINOMA; NONHUMAN; PRIORITY JOURNAL; REVIEW; STOMACH CARCINOMA; VIRUS CARCINOGENESIS; VIRUS GENE; VIRUS INFECTION;

EID: 0031969164     PISSN: 00720151     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (189)

1. Albeck, H., Nielsen, N. H., Hansen, H. E. et al. Epidemiology of nasopharyngeal and salivary gland carcinoma in Greenland. Arctic Med. Res., 51, 189-195 (1992).
2. Ambinder, R. F., Browning, P. J., Lorenzana, I. et al. Epstein-Barr virus and childhood Hodgkin's disease in Honduras and the United States. Blood, 81, 462-467 (1993).
3. Anagnostopoulos, I., Herbst, H., Niedobitek, G., and Stein, H. Demonstration of monoclonal EBV genomes in Hodgkin's disease and Ki-1-positive anaplastic large cell lymphoma by combined Southern blot and in situ hybridization. Blood, 74 (2), 810-816 (1989).
4. Axelsen, S. M. and Stamp, I. M. Lymphoepithelioma-like carcinoma of the vulvar region. Histopathology, 27, 281-283 (1995).
5. Barriga, F., Kiwanuka, J., Alvarez-Mon, M. et al. Significance of chromosome 8 breakpoint location in Burkitt's lymphoma: correlation with geographical origin and association with Epstein-Barr virus. Curr. Top. Microbiol. Immunol., 141, 129-137 (1988).
6. Biggar, R. J., Nkrumah, F. K., Neequaye, J., and Levine, P. H. Changes in presenting tumor site of Burkitt's lymphoma in Ghana, West Africa 1965-78. Br. J. Cancer, 43, 632-636 (1981).
7. Burke, A. P., Yen, T. S. B., Shekitka, K. M., and Sobin, L. H. Lymphoepithelial carcinoma of the stomach with Epstein-Barr virus demonstrated by polymerase chain reaction. Mod. Pathol., 3, 377-380 (1990).
8. Burkitt, D. P. A sarcoma involving the jaws in African children. Br. J. Surg., 46, 218-223 (1958).
9. Burkitt, D. P. General features and facial tumours in Burkitt's lymphoma. In "Burkitt's Lymphoma," ed. D. P. Burkitt and D. H. Wright, pp. 6-15 (1970). E & S Livingstone, Edinburgh.
10. Burkitt, D. P. Discovering Burkitt's lymphoma. In "Epstein-Barr Virus and Human Disease: 1988," ed. P. H. Levine et al., pp. xxi-xxxi (1989). Humana Press Inc., Clifton, New Jersey.
11. Burt, R. D., Vaughan, T. L., and McKnight, B. Descriptive epidemiology and survival analysis of nasopharyngeal carcinoma in the United States. Int. J. Cancer, 52, 549-556 (1992).
12. Butler, A., Colby, T. V., Weiss, L. M., and Lombard, C. Lymphoepithelioma-like carcinoma of the lung. Am. J. Surg. Pathol., 13, 632-639 (1989).
13. Carr, K. A., Bulengo, S., Weiss, L. M., and Nickoloff, B. J. Lymphoepithelioma-like carcinoma of the skin: a case report with immunophenotypic analysis and in situ hybridization for Epstein-Barr viral genome. Am. J. Surg. Pathol., 16, 909-913 (1992).
14. Carter, C. D., Brown, T. M. Jr., Herbert, J. T., and Heath, C. W. Jr. Cancer incidence following infectious mononucleosis. Am. J. Epidemiol., 105 (1), 30-36 (1977).
15. Chan, J. K. C., Hui, P.-K., Tsang, W. Y. W. et al. Primary lymphoepithelioma-like carcinoma of the lung. A clinicopathologic study of 11 cases. Cancer, 76, 413-422 (1995).
16. Chan, J. K. C., Yip, T. T. C., Tsang, W. Y. W. et al. Specific association of Epstein- Barr virus with lymphoepithelial carcinoma among tumors and tumor-like lesions of the salivary gland. Arch. Pathol. Lab. Med., 118, 994-997 (1994).
17. Chang, K. L., Albújar, P. F., Chen, Y.-Y., Johnson, R. M., and Weiss, L. M. High prevalence of Epstein-Barr virus in the Reed-Sternberg cells of Hodgkin's disease occurring in Peru. Blood, 81 (2), 496-501 (1993).
18. Cinque, P., Brytting, M., Vago, L. et al. Epstein-Barr virus DNA in cerebrospinal fluid from patients with AIDS-related primary lymphoma of the central nervous system. Lancet, 342, 398-401 (1993).
19. Connelly, R. R. and Christine, B. W. A cohort study of cancer following infectious mononucleosis. Cancer Res., 34, 1172-1178 (1974).
20. Correa, P. and O'Conor, G. T. Epidemiologic patterns of Hodgkin's disease. Int. J. Cancer, 8, 192-201 (1971).
21. de-Thé, G. The epidemiology of Burkitt's lymphoma: evidence for a causal association with Epstein-Barr virus. Epidemiol. Rev., 1, 32-54 (1979).
22. de-Thé, G., Geser, A., Day, N. E. et al. Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study. Nature, 274, 756-761 (1978).
23. de-Thé, G., Ho, J. H. C., and Muir, C. S. Nasopharyngeal carcinoma. In "Viral Infections of Humans: Epidemiology and Control," 3rd ed., ed. A. S. Evans, pp. 737-767 (1989). Plenum Publishing Corp., New York.
24. Desgranges, C., Wolf, H., de-Thé, G. et al. Nasopharyngeal carcinoma. X. Presence of Epstein-Barr genomes on separated epithelial cells of tumors in patients from Singapore, Tunisia, and Kenya. Int. J. Cancer, 16 (1), 7-15 (1975).
25. Devesa, S. S. and Fears, T. Non-Hodgkin's lymphoma time trends: United States and International Data. Cancer Res., 52, 5432s-5440s (1992).
26. Dickens, P., Srivastava, G., Loke, S. L., Chan, C. W., and Liu, Y. T. Epstein-Barr virus DNA in nasopharyngeal carcinoma from Chinese patients in Hong Kong. J. Clin. Pathol., 45 (5), 396-397 (1992).
27. Dietl, J., Horny, H.-P., and Kaiserling, E. Lymphoepithelioma-like carcinoma of the vagina: a case report with special reference to the immunophenotype of the tumor cells and tumor-infiltrating lymphoreticular cells. Int. J. Gynecol. Pathol., 13, 186-189 (1994).
28. Dimery, I. W., Lee, J. S., Blick, M., Pearson, G., Spitzer, G., and Hong, W. K. Association of the Epstein-Barr virus with lymphoepithelioma of the thymus. Cancer, 61, 2475-2480 (1988).
29. 28a. Enblad, G., Sandvej, K., Lennette, E. et al. Lack of correlation between EBV serology and presence of EBV in the Hodgkin and Reed-Sternberg cells of patients with Hodgkin's disease. Int. J. Cancer, 72, 394-397 (1997).
30. Epstein, M. A., Achong, B. H., and Barr, Y. M. Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet, i, 702-703 (1964).
31. Evans, A.S. The spectrum of infections with Epstein-Barr virus: a hypothesis. J. Infect. Dis., 124, 330-337 (1971).
32. Evans, A. S. and Comstock, G. W. Presence of elevated antibody titers to Epstein-Barr virus before Hodgkin's disease. Lancet, i, 1183-1186 (1981).
33. Forman, D., Newell, D. G., Fullerton, F. et al. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. Br. Med. J., 302 (6788), 1302-1305 (1991).
34. Fujii, T., Kawai, T., Saito, K. et al. EBER-1 expression in thymic carcinoma. Acta Pathol. Jpn., 43, 107-110 (1993).
35. Gaffey, M. J., Frierson, H. F., Mills, S. E. et al. Medullary carcinoma of the breast: identification of lymphocyte subpopulations and their significance. Mod. Pathol., 6 (6), 721-728 (1993).
36. Gal, A. A., Unger, E. R., Koss, M. N., and Yen, T. S. B. Detection of Epstein-Barr virus in lymphoepithelioma-like carcinoma of the lung. Mod. Pathol., 4, 264-268 (1991).
37. Gallo, O., Di Lollo, S., Graziani, P., Gallina, E., and Baroni, G. Detection of Epstein-Barr virus genome in sinonasal undifferentiated carcinoma by use of in situ hybridization. Otolaryngol. Head Neck Surg., 112, 659-664 (1995).
38. Gallo, O., Santucci, M., Calzolari, A., and Storchi, O.F. Epstein-Barr virus (EBV) infection and undifferentiated carcinoma of the parotid gland in Caucasian patients. Acta Otolaryngol. (Stockh), 114 (5), 572-575 (1994).
39. Glaser, S.L. and Jarrett, R. F. The epidemiology of Hodgkin's disease. Bailliere's Clin. Haematol., 9, 401-416 (1996).
40. Glaser, S. L., Ruby, J. L., Stewart, S. L. et al. Epstein-Barr virus-associated Hodgkin's disease: epidemiologic characteristics in international data. Int. J. Cancer, 70, 375-382 (1997).
41. Green, M. H., Fraumeni, J. F. Jr., and Hoover, R. Nasopharyngeal cancer among adults in the United States: racial variations by cell type. JNCI, 58, 1267-1270 (1977).
42. Gulley, M. L., Amin, M. B., Nicholls, J. M. et al. Epstein-Barr virus is detected in undifferentiated nasopharyngeal carcinoma but not in lymphoepithelioma-like carcinoma of the urinary bladder. Hum. Pathol., 26 (11), 1207-1214 (1995).
43. Gulley, M. L., Eagan, P. A., Quintanilla-Martinez, L. et al. Epstein-Barr virus DNA is abundant and monoclonal in the Reed-Sternberg cells of Hodgkin's disease: association with mixed cellularity subtype and Hispanic American ethnicity. Blood, 83, 1595-1602 (1994).
44. Gulley, M. L., Pulitzer, D. R., Eagan, P. A., and Schneider, B. G. Epstein-Barr virus infection is an early event in gastric carcinogenesis and is independent of bcl-2 expression and p53 accumulation. Hum. Pathol., 27, 20-27 (1995).
45. Haenszel, W. Variation in incidence of and mortality from stomach cancer, with particular reference to the United States. JNCI, 21, 213-262 (1958).
46. Hamilton-Dutoit, S., Hamilton-Therkildsen, M., Nielsen, H., Jensen, H., Hansen, H., and Pallesen, G. Undifferentiated carcinoma of the salivary gland in Greenlandic eskimos: demonstration of Epstein-Barr virus DNA by in situ nucleic acid hybridization. Hum. Pathol., 22, 811-815 (1991).
47. Hanto, D.W., Frizzera, G., Purtilo, D. T. et al. Clinical spectrum of lympho-proliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus. Cancer Res., 41, 4253-4261 (1981).
48. Harada, S., Tatsumi, E., Lipscomb, H., and Purtilo, D. T. Responses to Epstein-Barr virus in immune deficient patients. In "Immune Deficiency and Cancer," ed. D. T. Purtilo, pp. 123-141 (1984). Plenum Medical Book Co., New York and London.
49. Harabuchi, Y., Yamanaka, N., Kataura, A. et al. Epstein-Barr virus in nasal T-cell lymphomas in patients with lethal midline granuloma. Lancet, 335, 128-130 (1990).
50. Hartge, P., Devesa, S. D., and Fraumeni, J. F. Hodgkin's and non-Hodgkin's lymphomas cancer surveys. Cancer Surv., 19/20, 423-453 (1994).
51. Henle, G. and Henle, W. Immunofluorescence in cells derived from Burkitt's lymphoma. J. Bacteriol., 91, 1248-1256 (1966).
52. Henle, G. and Henle, W. Epstein-Barr virus-specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma. Int. J. Cancer, 17, 1-7 (1976).
53. Henle, W., Henle, G., and Ho, H.-C. Antibodies to Epstein-Barr virus in nasopharyngeal carcinoma, other head and neck neoplasms, and control groups. JNCI, 44, 225-231 (1970).
54. Henle, W., Ho, J.H.-C., Henle, G., and Kwan, H.C. Antibodies to Epstein-Barr virus-related antigens in nasopharyngeal carcinoma. Comparison of active cases with long-term survivors. JNCI, 51 (2), 361-369 (1973).
55. Henle, W., Ho, J.H.C., Henle, G., Chau, J.C., and Kwan, H.C. Nasopharyngeal carcinoma: significance of changes in Epstein-Barr virus-related antibody patterns following therapy. Int. J. Cancer, 20 (5), 663-672 (1977).
56. Hildesheim, A. and Levine, P. H. Etiology of nasopharyngeal carcinoma: a review. Epidemiol. Rev., 15, 466-485 (1993).
57. Ho, J. H. C. Current knowledge of the epidemiology of nasopharyngeal carcinoma - a review. IARC Sci. Publ., 2, 357-366 (1972).
58. Ho, J. H. An epidemiologic and clinical study of nasopharyngeal carcinoma. Int. J. Radiat. Oncol. Biol. Phys., 4, 193-198 (1978).
59. Ho, J. H. C. Genetic and environmental factors in nasopharyngeal carcinoma. In "Recent Advances in Human Tumor Virology and Immunology," ed. W. Nakahara, pp. 275-295 (1971). University Park Press, Baltimore, Maryland.
60. Ho, J. H. C. Nasopharyngeal carcinoma (NPC). Adv. Cancer Res., 15, 57-92 (1972).
61. Hsu, H.-C., Chen, C.-C., Huang, G.-T., and Lee, P.-H. Clonal Epstein-Barr virus associated cholangiocarcinoma with lymphoepithelioma-like component. Hum. Pathol., 27, 848-850 (1996).
62. Huang, D. P., Ng, H. K., Ho, Y. H., and Chan, K. M. Epstein-Barr virus (EBV)-associated undifferentiated carcinoma of the parotid gland. Histopathology, 13, 509-517 (1988).
63. Huh, J., Park, C., Sangwoo, J., Kim, C. E., Poppema, S., and Kim, C. A pathologic study of Hodgkin's disease in Korea and its association with the Epstein-Barr virus infection. Cancer, 77, 949-955 (1996).
64. lezzoni, J. C., Gaffey, M. J., and Weiss, L. M. The role of Epstein-Barr virus in lymphoepithelioma-like carcinoma. Am. J. Clin. Pathol., 103, 308-315 (1995).
65. Imai, S., Koizumi, S., Sugiura, M. et al. Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc. Natl. Acad. Sci. USA, 91, 9131-9135 (1994).
66. Jarrett, R. F., Gallagher, A., Jones, D. B. et al. Detection of Epstein-Barr virus genomes in Hodgkin's disease: relation to age. J. Clin. Pathol., 44, 844-848 (1991).
67. Johannson, B., Klein, G., Henle, W., and Henle, G. Epstein-Barr virus (EBV)-associated antibody patterns in malignant lymphoma and leukemia. I. Hodgkin's disease. Int. J. Cancer, 6, 450-462 (1970).
68. Jones, E. H., Biggar, R. J., Nkrumah, F. K., and Lawler, S. D. HLA-DR7 association with African Burkitt's lymphoma. Human Imuunol., 13, 211-217 (1985).
69. Jones, J. F., Shurin, S., Abramowsky, C. et al. T-cell lymphoma containing Epstein- Barr viral DNA in patients with chronic Epstein-Barr virus infections. N. Engl. J. Med., 318, 733-741 (1988).
70. Kikuta, H., Taguchi, Y., Tomizawa, K. et al. Epstein-Barr virus genome-positive T lymphocytes in a boy with chronic active EBV infection associated with Kawasaki-like disease. Nature, 333, 455-457 (1988).
71. Kinlen, L. J. Immunosuppressive therapy and cancer. Cancer Surv., 1, 565-583 (1982).
72. Klein, G., Giovanella, B. C., Lindahl, T., Fialkow, P. J., Singh, S., and Stehlin, J. S. Direct evidence for the presence of Epstein-Barr virus DNA and nuclear antigen in malignant epithelial cells from patients with poorly differentiated carcinoma of the nasopharynx. Proc. Natl. Acad. Sci. USA, 71 (12), 4737-4741 (1974).
73. Kotsianti, A., Costopoulos, J., Morgello, S., and Papadimitriou, C. Undifferentiated carcinoma of the parotid gland in a white patient: detection of Epstein-Barr virus by in situ hybridization. Hum. Pathol., 27, 87-90 (1996).
74. Krishnamurthy, S., Lanier, A. P., Dohan, P., Lanier, J. F., and Henle, W. Salivary gland cancer in Alaskan natives, 1966-1980. Hum. Pathol., 18, 986-996 (1987).
75. Kvale, G., Hoiby, E. A., and Pedersen, E. Hodgkin's disease in patients with previous infectious mononucleosis. Int. J. Cancer, 23, 593-597 (1979).
76. Lange, B., Arbeter, A., Hervetson, J., and Henle, W. Longitudinal study of Epstein-Barr virus antibody titers and excretion in pediatric patients with Hodgkin's disease. Int. J. Cancer, 22, 521-527 (1978).
77. Lanier, A. P., Bender, T. R., Blot, W. J., Fraumeni, J. F. Jr., and Ward, B. H. Cancer incidence in Alaska natives. Int. J. Cancer, 18, 409-412 (1976).
78. Lanier, A., Clift, S. R., Bornkamm, G., Henle, W., Goepfert, H., and Raab-Traub, N. Epstein-Barr virus and malignant lymphoepithelial lesions of the salivary gland. Arct. Med. Res., 50, 55-61 (1991).
79. Lanier, A. P., Henle, W., Bender, T. R., Henle, G., and Talbot, M. L. Epstein-Barr virus-specific antibody titers in seven Alaskan natives before and after diagnosis of nasopharyngeal carcinoma. Int. J. Cancer, 26 (2), 133-138 (1980).
80. Lanier, A. P., Bornkamm, G. W., Henle, W. et al. Association of Epstein-Barr virus with nasopharyngeal carcinoma in Alaskan native patients: serum antibodies and tissue EBNA and DNA. Int. J. Cancer, 28 (3), 301-305 (1981).
81. Lantorp, K., Wahren, B., and Hanngren, A. Infectious mononucleosis and depression of cellular immunity. BMJ, 4, 668 (1972).
82. Lee, E. S., Locker, J., Nalesnik, M. et al. The association of Epstein-Bar virus with smooth-muscle tumors occurring after organ transplantation. N. Engl. J. Med., 332, 19-25 (1995).
83. Leoncini, L., Spina, D., Nyong'o, A. et al. Neoplastic cells of Hodgkin's disease show differences in EBV expression between Kenya and Italy. Int. J. Cancer, 65, 781-784 (1996).
84. Leoncini, L., Vindigni, C., Megha, T. et al. Epstein-Barr virus and gastric cancer: data and unanswered questions. Int. J. Cancer, 53, 898-901 (1993).
85. Lespagnard, L., Cochaux, P., Larsimont, D., Degeyter, M., Velu, T., and Heimann, R. Absence of Epstein-Barr virus in medullary carcinoma of the breast as demonstrated by immunophenotyping, in situ hybridization and polymerase chain reaction. Am. J. Clin. Pathol., 103, 449-452 (1995).
86. Leung, S. Y., Chung, L. P., Yuen, S. T., Ho, C. M., Wong, M. P., and Chan, S. Y. Lymphoepithelial carcinoma of the salivary gland: in situ detection of Epstein-Barr virus. J. Clin. Pathol., 48, 1022-1027 (1995).
87. Levine, P. H. The etiology of Hodgkin's disease. In "Pathobiology Annual," ed. H. L. Ioachim, pp. 143-170 (1974). Appleton-Century-Crofts, New York.
88. Levine, P. H., Ablashi, D. V., Berard, C. W., Carbone, P. P., Waggoner, D. E., and Malan, L. Elevated antibody titers to herpes-type virus in Hodgkin's disease. Proc. Am. Assoc. Cancer Res., 11, 49 (1970).
89. Levine, P. H. Immunologic markers for Epstein-Barr virus in the control of nasopharyngeal carcinoma and Burkitt's lymphoma. Cancer Detect. Prev. Suppl., 1, 217-223 (1987).
90. Levine, P. H., Ablashi, D. V., Berard, C. W., Carbone, P. P., Waggoner, D. E., and Malan, L. Elevated antibody titers to Epstein-Barr virus in Hodgkin's disease. Cancer, 27, 416-421 (1971).
91. Levine, P. H. and Blattner, W. A. The epidemiology of human virus-associated hematologic malignancies. Leukemia and related diseases. Leukemia, 6, 54S-59S (1992).
92. Levine, P. H., Connelly, R. R., and McKay, F. W. Burkitt's lymphoma cases reported to the American Burkitt's Lymphoma Registry compared with population-based incidence and mortality data. In "Burkitt's Lymphoma: A Human Cancer Model," ed. G. M. Lenior, G. T. O'Conor, and C. L. M. Olweny, pp. 217-224 (1985). International Agency for Research on Cancer, Lyon, France.
93. Levine, P. H., Fraumeni, J. F. Jr., Reisher, J. I., and Waggoner, D. E. Antibodies to Epstein-Barr virus-associated antigens in relatives of cancer patients. J. Natl. Cancer Inst., 52, 1037-1040 (1974).
94. Levine, P. H., Kamaraju, L. S., Connelly, R. R. et al. The American Burkitt's lymphoma registry: eight years' experience. Cancer, 49, 1016-1022 (1982).
95. Levine, P. H., Pallesen, G., Ebbesen, P., Harris, N., Evans, A. S., and Mueller, N. Evaluation of Epstein-Barr virus antibody patterns and detection of viral markers in the biopsies of patients with Hodgkin's disease. Int. J. Cancer, 59, 48-50 (1994).
96. Levine, P. H., Stemmermann, G., Lennette, E. T., Hildesheim, A., Shibata, D., and Nomura, A. Elevated antibody titers to Epstein-Barr virus prior to the diagnosis of Epstein-Barr-virus-associated gastric adenocarcinoma. Int. J. Cancer, 60, 642-644 (1995).
97. Leyvraz, S., Henle, W., Chahinian, A. P. et al. Association of Epstein-Barr virus with thymic carcinoma. N. Engl.J. Med., 312 (20), 1296-1299 (1985).
98. Lin, A. Y., Kingma, D. W., Lennette, E. T. et al. Epstein-Barr virus and familial Hodgkin's disease. Blood, 88 (8), 3160-3165 (1996).
99. Lopatequi, J. R., Gaffey, M. J., Fierson, H. F. Jr. et al. Detection of Epstein-Barr viral RNA in sinonasal undifferentiated carcinoma from Western and Asian patients. Am. J. Surg. Pathol., 18, 391-398 (1994).
100. Mack, T. M., Cozen, C., Shibata, D.K. et al. Concordance for Hodgkin's disease in identical twins suggesting genetic susceptibility to the young-adult form of the disease. N. Engl. J. Med., 332, 413-418 (1995).
101. MacMahon, B. Epidemiological evidence on the nature of Hodgkin's disease. Cancer, 10, 1045-1054 (1957).
102. MacMahon, E. M. E., Glass, J. D., Hayward, S. D. et al. Epstein-Barr virus in AIDS- related primary central nervous system lymphoma. Lancet, 338, 969-973 (1991).
103. Mangi, R. J., Niederman, J. C., and Helleher, J. E. Jr. Depression of cell-mediated immunity during acute infectious mononucleosis. N. Engl. J. Med., 291, 1149-1153 (1974).
104. Matias-Guiu, X., Komminoth, P., and Prat, J. Absence of Epstein-Barr virus DNA in lymphoepithelioma-like carcinoma of the uterine cervix. Am. J. Pathol., 101, 117 (1994).
105. McClain, K. L., Leach, C. T., Jenson, H. B. et al. Association of Epstein-Barr virus with leiomyosarcomas in young people with AIDS. N. Engl. J. Med., 332, 12-18 (1995).
106. McGuire, L. J., Huang, D. P., Teoh, R., Arnold, M., Wong, K., and Lee, J. C. Epstein-Barr virus genome in thymoma and thymic lymphoid hyperplasia. Am. J. Pathol., 131 (3), 385-390 (1988).
107. Miller, B., Montgomery, C., Watne, A. L., Johnson, D., Bailey, T., and Kowalski, P. Lymphoepithelioma-like carcinoma of the lung. J. Surg. Oncol., 48 (1), 62-68 (1991).
108. Miller, R. W. and Beebe, G. W. Infectious mononucleosis and the empirical risk of cancer. J. Natl. Cancer Inst., 50, 315-321 (1973).
109. Min, K.-W., Holmquist, S., Peiper, S. C., and O'Leary, T.J. Poorly differentiated adenocarcinoma with lymphoid stroma (lymphoepithelioma-like carcinomas) of the stomach: report of three cases with Epstein-Barr virus genome demonstrated by the polymerase chain reaction. Am. J. Clin. Pathol., 96, 219-227 (1991).
110. Mori, M., Watanabe, M., Tanaka, S., Mimori, K., Kuwano, H., and Sugimachi, K. Epstein-Barr virus-associated carcinomas of the esophagus and stomach. Arch. Pathol. Lab. Med., 118, 998-1001 (1994).
111. Morrow, R. H., Pike, M. C., Smith, P. G., Ziegler, J. L., and Kisuule, A. Burkitt's lymphoma: a time-space cluster of cases in Bwamba county of Uganda. Br. Med. J., 2 (760), 491-492 (1971).
112. Mosier, D. E., Picchio, G. R., Baird, S. M., Kobayashi, R., and Kipps, T. J. Epstein-Barr virus-induced human B-cell lymphomas in SCID mice reconstituted with human peripheral blood leukocytes. Cancer Res., 52, 5552s-5553s (1992).
113. Mueller, N. Hodgkin's disease. In "Cancer Epidemiology and Prevention," ed. D. Schottenfeld and J. F. Fraumeni, Jr., pp. 893-919 (1996). Oxford University Press, New York.
114. Mueller, N. The EBV and Hodgkin's disease: an epidemiologic paradox. Epstein-Barr Virus Rep., 4, 1-2 (1997).
115. Mueller, N., Evans, A., Harris, N. L. et al. Hodgkin's disease and Epstein-Barr virus: altered antibody pattern before diagnosis. N. Engl. J. Med., 320, 689-695 (1989).
116. Muir, C., Waterhouse, J., Mack, T. et al. (eds.) "Cancer Incidence in Five Continents, Vol. 5," (1987). IARC Scientific Publications, No. 88, International Agency for Research on Cancer, Lyon, France.
117. Munoz, N., Davidson, R. J. L., Witthoff, B., Ericsson, J. E., and de-Thé, G. Infectious mononucleosis and Hodgkin's disease. Int. J. Cancer, 22 (1), 10-13 (1978).
118. Naegele, R.F., Champion, J., Murphy, S., Henle, G., and Henle, W. Nasopharyngeal carcinoma in American children: Epstein-Barr virus-specific antibody titers and prognosis. Int. J. Cancer, 29 (2), 209-212 (1982).
119. Nagao, T., Ishida, Y., Sugano, I. et al. Epstein-Barr virus-associated undifferentiated carcinoma with lymphoid stroma of the salivary gland in Japanese patients. Cancer, 78, 695-703 (1996).
120. Niederman, J. C., McCollum, R. W., Henle, G., and Henle, W. Infectious mononucleosis: clinical manifestations in relation to EB virus antibodies. JAMA, 203, 205-209 (1968).
121. Niedobitek, G., Hansmann, M. L., Berbst, H. et al. Epstein-Barr virus and carcinomas: undifferentiated carcinomas but not squamous cell carcinomas of the nasopharynx are regularly associated with the virus. J. Pathol., 165, 17-24 (1991).
122. Niedobitek, G., Herbst, H., Young, L.S. et al. Epstein-Barr virus and carcinomas: expression of the viral genome in an undifferentiated gastric carcinoma. Diagn. Mol. Pathol., 1 (2), 103-108 (1992).
123. Niehues, T., Harms, D., Jurgens, H., and Gobel, U. Treatment of pediatric malignant thymoma: long-term remission in a 14-year-old boy with EBV-associated thymic carcinoma by aggressive, combined modality treatment. Med. Pediatr. Oncol., 26, 419-424 (1996).
124. Nomura, A. Stomach cancer. In "Cancer Epidemiology and Prevention," ed. D. Schottenfeld and J. F. Fraumeni, Jr., pp. 707-724 (1996). Oxford University Press, New York.
125. Nutting, P. A., Freeman, W. L., Risser, D. R. et al. Cancer incidence among American Indians and Alaska Natives, 1980 through 1987. Am. J. Public Health, 83 (11), 1589-1598 (1993).
126. Oda, K., Tamaru, J., Takenouchi, T. et al. Association of Epstein-Barr virus with gastric carcinoma with lymphoid stroma. Am. J. Pathol., 143 (4), 1063-1071 (1993).
127. Ohshima, K., Kikuchi, M., Eguchi, F. et al. Analysis of Epstein-Barr viral genomes in lymphoid malignancy using Southern blotting, polymerase chain reaction and in situ hybridization. Virchows Arch. B, 59, 383-390 (1990).
128. Old, L. J., Boyse, E. A., Oettgen, H. F. et al. Precipitation antibody in human serum to an antigen present in cultured Burkitt's lymphoma cells. Proc. Natl. Acad. Sci. USA, 56, 1699-1704 (1966).
129. Ortiz-Frutos, F. J., Zarco, C., Gil, R., Ballestin, C., and Iglesias, L. Lymphoepithelioma-like carcinoma of the skin. Clin. Exp. Dermatol., 18, 83-86 (1993).
130. Pagano, J. S., Huang, C. H., Klein, G. et al. Homology of Epstein-Barr viral DNA in nasopharyngeal carcinoma from Kenya, Taiwan, Singapore and Tunis. In "Oncogenesis and Herpesviruses II," ed. G. de-Thé, M. A. Epstein, and H. zur Hausen, pp. 191-193 (1975). International Agency for Research on Cancer, Lyon, France.
131. Pallesen, G., Hamilton-Dutoit, S. J., Rowe, M., and Young, L. S. Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin's disease. Lancet, 337, 320-322 (1991).
132. Pallesen, G., Hamilton-Dutoit, S.J., and Zhou, X. The association of Epstein-Barr virus (EBV) with T cell lymphoproliferation and Hodgkin's disease: two new developments in the EBV field. Adv. Cancer Res., 62, 179-239 (1993).
133. Parkin, D. M., Sohier, R., and O'Conor, G. T. Geographic distribution of Burkitt's lymphoma. In "Burkitt's Lymphoma: A Human Cancer Model," IARC Scientific Publications, No. 60, (1985). International Agency for Research on Cancer, Lyon.
134. Parkin, D.M., Muir, C. S., Whelan, S. L. et al. (eds.) "Cancer Incidence in Five Continents, Vol. 6," (1992). IARC Scientific Publications, No. 120, International Agency for Research on Cancer, Lyon.
135. Parsonnet, J., Friedman, G. D., Vanderstein, D. P. et al. Helicobacter pylori infection and the risk of gastric carcinoma. N. Engl. J. Med., 325 (16), 1127-1131 (1991).
136. Patton, D. F., Ribeiro, R. C., Jenkins, J. J., and Sixbey, J. W. Thymic carcinoma with a detective Epstein-Barr virus encoding the BZLF1 transactivation. J. Infect. Dis., 170, 7-12 (1994).
137. Pike, M. C. and Morrow, R. H. Some epidemiological problems with "EBV + Malaria gives BL" - A review. In "Oncogenesis and Herpesviruses," ed. P. M. Biggs, G. de-Thé, and L. N. Payne, pp. 349-350 (1972). International Agency for Research in Cancer, Lyon.
138. 136a. Pisani, P., Parkin, D. M., Muñoz, N., and Ferlay, J. Cancer and infection: estimates of the attributable fraction in 1990. Cancer Epid. Biomarkers and Prevention, 6, 387-400 (1997).
139. Pittaluga, S., Loke, S. L., So, K. C., Cheung, K. N., and Ma, L. Clonal Epstein-Barr virus in lymphoepithelioma-like carcinoma of the stomach: demonstration of viral genome by in situ hybridization and Southern blot analysis. Mod. Pathol., 5, 661-664 (1992).
140. Pittaluga, S., Wong, M. P., Chung, L. P., and Loke, S.-L. Clonal Epstein-Barr virus in lymphoepithelioma-like carcinoma of the lung. Am. J. Surg. Pathol., 17, 678-682 (1993).
141. Purtilo, D. T. Immune deficiency predisposing to Epstein-Barr virus-induced lymphoproliferative diseases: the X-linked lymphoproliferative syndrome as a model. Adv. Cancer Res., 34, 279-312 (1981).
142. Purtilo, D. T. X-linked lymphoproliferative syndrome. An immunodeficiency disorder with acquired agammaglobulinemia, fatal infectious mononucleosis, or malignant lymphoma. Arch. Pathol. Lab. Med., 105 (3), 119-121 (1981).
143. Purtilo, D. T., Cassell, C. K., Yang, J. P., and Harper, P. X-linked recessive progressive combined variable immunodeficiency (Duncan's disease). Lancet, i, 935-940 (1975).
144. Raab-Traub, N., Flynn, K., Pearson, G. et al. The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA. Int. J. Cancer, 39, 25-29 (1987).
145. Raab-Traub, N., Rajadurai, P., Flynn, K., and Lanier, A. P. Epstein-Barr virus infection in carcinoma of the salivary gland. J. Virol., 65, 7032-7036 (1991).
146. Rabkin, C. S., Ward, M. H., Manns, A., and Blattner, W. A. Epidemiology of non-Hodgkin's lymphoma. In "Non-Hodgkin's Lymphomas: Epidemiology and Pathogenesis," ed. I. P. Magrath, pp. 171-186 (1997). Edward Arnold, London.
147. Rosdahl, N., Larsen, S. O., and Clemmesen, J. Hodgkin's disease in patients with previous infectious mononucleosis: 30 years' experience. Br. Med. J. 2, 253-256 (1974).
148. Saemundsen, A. K., Albeck, H., Hansen, J. P. et al. Epstein-Barr virus in nasopharyngeal and salivary gland carcinomas in Greenland Eskimos. Br. J. Cancer, 46 (5), 721-728 (1982).
149. Shek, T. W. H., Luk, I. S. C., Ng, I. O. L., and Lo, C. Y. Lymphoepithelioma-like carcinoma of the thyroid gland: lack of evidence of association with Epstein-Barr virus. Hum. Pathol., 27, 851-853 (1996).
150. Shepherd, J. J. and Wright, D. H. Burkitt's tumour presenting as bilateral swelling of the breast in women of child-bearing age. Br. J. Surg., 54 (9), 776-780 (1967).
151. Shibata, D., Hawes, D., Stemmermann, G. N., and Weiss, L. M. Epstein-Barr virus-associated gastric adenocarcinoma among Japanese Americans in Hawaii. Cancer Epidemiol. Biomarkers Prev., 2, 213-217 (1993).
152. Shibata, D., Tokunaga, M., Uemura, Y., Sato, E., Tanaka, S., and Weiss, L. M. Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Lymphoepithelioma-like carcinoma. Am. J. Pathol., 139 (3), 469-474 (1991).
153. Shibata, D. and Weiss, L. M. Epstein-Barr virus associated gastric adenocarcinoma. Am. J. Pathol., 140, 769-774 (1992).
154. Shin, W. S., Kang, M. W., Kang, J. H. et al. Epstein-Barr virus-associated gastric adenocarcinomas among Koreans. Am. J. Clin. Pathol., 105, 173-181 (1996).
155. Shiramizu, B., Barriga, F., Neequaye, J. et al. Patterns of chromosomal breakpoint locations in Burkitt's lymphoma: relevance to geography and EBV association. Blood, 77, 1516-1526 (1991).
156. Shope, T. C., Khalifa, S., Smith, S. T., and Cushing, B. Epstein-Barr virus antibody in childhood Hodgkin's disease. Am. J. Dis. Child., 136, 701-703 (1982).
157. Smith, R. D. Epstein-Barr virus: a ubiquitous agent that can immortalize cells. Hum. Pathol., 24, 233-234 (1993).
158. Su, I. J. and Hsieh, H. C. Clinicopathological spectrum of Epstein-Barr virus-associated T cell malignancies. Leuk. Lymphoma, 7 (1-2), 47-53 (1992).
159. Tamada, A., Makimoto, K., Yamabe, H. et al. Titers of Epstein-Barr virus-related antibodies in nasopharyngeal carcinoma in Japan. Cancer, 53 (3), 430-440 (1984).
160. Timmons, C. F., Dawson, D. B., Richards, C. S., Andrews, W. S., and Katz, J. A. Epstein-Barr virus-associated leiomyosarcomas in liver transplantation recipients. Cancer, 76, 1481-1489 (1995).
161. Tirelli, U., Errante, D., Dolcetti, R. et al. Hodgkin's disease and human immunodeficiency virus infection: clinicopathologic and virologic features of 114 patients from the Italian cooperative group on AIDS and tumors. J. Clin. Oncol., 13, 1758-1767 (1995).
162. Tokunaga, M., Imai, S., Uemura, Y., Tokudome, T., Osato, T., and Sato, E. Epstein-Barr virus in adult T-cell leukemia/lymphoma. Am. J. Pathol., 143, 1263-1269 (1993).
163. Tokunaga, M., Land, C.E., Uemura, Y., Tokudome, T., Tanaka, S., and Sato, E. Epstein-Barr virus in gastric carcinoma. Am. J. Pathol., 143, 1250-1254 (1993).
164. Tokunaga, M., Uemura, Y., Tokudome, T. et al. Epstein-Barr virus related gastric cancer in Japan: a molecular patho-epidemiological study. Acta Pathol. Jpn., 43, 574-581 (1993).
165. Tomita, Y., Ohsawa, M., Kanno, H. et al. Epstein-Barr virus in Hodgkin's disease patients in Japan. Cancer, 77, 186-192 (1996).
166. Tsai, C.-C., Chen, C.-L., and Hsu, H.-C. Expression of Epstein-Barr virus in carcinomas of major salivary glands: a strong association with lymphoepithelioma-like carcinoma. Hum. Pathol., 27, 258-262 (1996).
167. Uccini, S., Monardo, F., Stoppacciaro, A. et al. High frequency of Epstein-Barr virus genome detection in Hodgkin's disease of HIV-positive patients. Int. J. Cancer, 46, 581-585 (1990).
168. Vaughan, T. L., Shapiro, J. A., Burt, R. D. et al. Nasopharyngeal cancer in a low-risk population: defining risk factors by histological type. Cancer Epidemiol. Biomarkers Prev., 5, 587-593 (1996).
169. Wara, W. M., Wara, D. W., Phillips, T. L., and Ammann, A. J. Elevated IgA in carcinoma of the nasopharynx. Cancer, 35 (5), 1313-1315 (1975).
170. Warren, J. R. and Marshall, B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet, i, 1273-1275 (1983).
171. Weinberg, E., Hoisington, S., Eastman, A. Y., Rice, D. K., Malfetano, J., and Ross, J.S. Uterine cervical lymphoepithelioma-like carcinoma. Absence of Epstein-Barr virus genomes. Am. J. Clin. Pathol., 99 (2), 195-199 (1993).
172. Weiss, L. M., Movahed, L. A., Butler, A. E. et al. Analysis of lymphoepithelioma and lymphoepithelioma-like carcinomas for Epstein-Barr virus genomes by in situ hybridization. Am. J. Surg. Pathol., 13 (8), 625-631 (1989).
173. Weiss, L. M., Strickler, J. G., Warnke, R. A., Purtilo, D. T., and Sklar, J. Epstein-Barr viral DNA in tissue of Hodgkin's disease. Am. J. Pathol., 129 (1), 86-91 (1987).
174. Wolf, H., zur Hausen, H., and Becker, V. EB viral genomes in epithelial nasopharyngeal carcinoma cells. Nature New Biol., 244, 245-257 (1973).
175. Wolf, H., zur Hausen, H., Klein, G., Becker, V., Henle, G., and Henle, W. Attempts to detect virus-specific DNA sequences in human tumors. III. Epstein-Barr viral DNA in non-lymphoid nasopharyngeal carcinoma cells. Med. Microbiol. Immunol., 161 (1), 15-21 (1975).
176. Wong, M. P., Chung, L. P., Yuen, S. T. et al. In situ detection of Epstein-Barr virus in non-small cell lung carcinomas. J. Pathol., 177, 233-240 (1995).
177. Wu, T.-C. and Kuo, T.-T. Study of Epstein-Barr virus early RNA1 (EBER1) expression by in situ hybridization in thymic epithelial tumors of Chinese patients in Taiwan. Hum. Pathol., 24, 235-238 (1993).
178. Wu, T.-C., Mann, R. B., Charache, P. et al. Detection of EBV gene expression in Reed-Sternberg cells of Hodgkin's disease. Int. J. Cancer, 46, 801-804 (1990).
179. Yeung, W. M., Zong, Y. S., Chiu, C. T. et al. Epstein-Barr virus carriage by nasopharyngeal carcinoma in situ. Int. J. Cancer, 53 (5), 746-750 (1993).
180. Yu, M. C. and Henderson, B. E. Nasopharyngeal cancer. In "Cancer Epidemiology and Prevention," ed. D. Schottenfeld and J. F. Fraumeni, Jr., pp. 893-919 (1996). Oxford University Press, New York.
181. Zarate-Osorno, A., Roman, L. N., Kingma, D.W., Meneses-Garcia, A., and Jaffe, E. S. Hodgkin's disease in Mexico. Prevalence of Epstein-Barr virus sequences and correlations with histologic subtype. Cancer, 75, 1360-1366 (1995).
182. Zeng, Y. Sero-epidemiological studies on nasopharyngeal carcinoma in China. Adv. Cancer Res., 44, 121-138 (1985).
183. Zeng, Y., Zhang, L. G., Wu, Y. C. et al. Prospective studies on nasopharyngeal carcinoma in Epstein-Barr virus IgA/VCA antibody-positive persons in Wuzhou City, China. Int. J. Cancer, 36, 545-547 (1985).
184. Zeng, Y., Zhong, J. M., Li, L. Y. et al. Follow-up studies on Epstein-Barr virus IgA/ VCA antibody-positive persons in Zangwu County, China. Intervirology, 20, 190-194 (1983).
185. Zheng, Y. M., Tuppin, P., Hubert, A. et al. Environmental and dietary risk factors for nasopharyngeal carcinoma: a case-control study in Zangwu County, Guangxi, China. Br. J. Cancer, 69 (3), 508-514 (1994).
186. Zhou, X. G., Hamilton-Dutoit, S., Yan, Q.H., and Pallesen, G. The association between Epstein-Barr virus and Chinese Hodgkin's disease. Int. J. Cancer, 55, 359-363 (1993).
187. Zukerberg, L. R., Harris, N. L., and Young, R. H. Carcinomas of the urinary bladder simulating malignant lymphoma: a report of five cases. Am. J. Surg. Pathol., 15, 569-576 (1991).
188. zur Hausen, H., Schulte-Holthausen, H., Klein, G. et al. EB-virus DNA in biopsies of Burkitt tumors and anaplastic carcinomas of the nasopharynx. Nature, 228, 1056-1057 (1970).
189. Zutter, M. M., Martin, P. J., Sale, G.E. et al. Epstein-Barr virus lymphoproliferation after bone marrow transplantation. Blood, 72, 520-529 (1988).