A novel histamine 2(H2) receptor antagonist with gastroprotective activity. II. Synthesis and pharmacological evaluation of 2-furfuryl-thio and 2-furfurylsulfinyl acetamide derivatives with heteroaromatic rings

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 4, 1998, Pages 616-622

  Hirakawa, Nobuhiko ^a   Matsumoto, Hajime ^a   Hosoda, Akihiko ^a   Sekine, Akihiro ^a   Yamaura, Tetsuaki ^a   Sekine, Yasuo ^a  

^a FUJIREBIO INC   (Japan)

Author keywords

FRG 8813; Furfurylsulfinyl group; Gastroprotection; Histamine H2 receptor antagonist; N 4 4 (piperidinomethyl) 2 pyridyloxy (Z) 2 butenyl acetamide derivative

Indexed keywords

ANTIULCER AGENT; HISTAMINE H2 RECEPTOR ANTAGONIST; LAFUTIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; MALE; NONHUMAN; RAT; STOMACH ACID SECRETION; STOMACH PROTECTION; STOMACH ULCER; STRUCTURE ACTIVITY RELATION;

EID: 0031967716     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.616     Document Type: Article

References (7)

1. Part I Sekine Y., Hirukuwa N., Kashiwaba N., Matsumoto H., Kutsuma T., Yamaura T., Sekine S., Preceding paper in this journal.
2. Brimlecombe R. W., Duncan W. A., Durant G. J., Ganellin C. R., Parsons M. E., Black J. W., Br. J. Pharmacol., 53, 435-436 (1975).
3. Takeda M., Takagi T., Yoshida Y., Maeno H., Arzneim. Forsch., 32(II), 734-737 (1982).
4. Tarunami M., Sakuma H., Shiratsuchi K., Mieda M., Arzneim. Forsch., 35(I), 703-706 (1985).
5. Onodera S., Shihata M.,Tanaka M., Inaha N., Yamaura T., Ohnisi H., Jpn. J. Pharmacol., 68, 161-173 (1995).
6. Ichikawa T., Ishihara K., Shihata M., Yamaura T., Suigenji K., Hotta K., Eur. J. Pharmacol., 297, 87-92 (1996).
7. Ghosh M. N., Schild H. O., Br. J. Phamcol., 13, 54-61 (1958).