A novel histamine 2(H2) receptor antagonist with gastroprotective activity. I. Synthesis and pharmacological evaluation of N- phenoxypropylacetamide derivatives with thioether function

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 4, 1998, Pages 610-615

  Sekine, Yasuo ^a   Hirakawa, Nobuhiko ^a   Kashiwaba, Noriaki ^a   Matsumoto, Hajime ^a   Kutsuma, Teruo ^a   Yamaura, Tetsuaki ^a   Sekine, Akihiro ^a  

^a FUJIREBIO INC   (Japan)

Author keywords

FRG 8701; Furfurylsulfinyl group; Gastroprotection; Histamine H2 receptor antagonist; N (phenoxypropyl)acetamide with thioether moiety

Indexed keywords

2 FURFURYLSULFINYL N [3 [3 (PIPERIDINOMETHYL)PHENOXY]PROPYL]ACETAMIDE; ANTIULCER AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG CONFORMATION; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; MALE; NONHUMAN; RAT; STOMACH ACID SECRETION; STOMACH PROTECTION; STOMACH ULCER; STRUCTURE ACTIVITY RELATION;

EID: 0031967651     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.610     Document Type: Article

References (16)

1. Brimlecombe R. W., Duncan W. A., Durant G. J., Ganellin C. R., Parsons M. E., Black J. W., Br. J. Pharmacol., 53, 435-436 (1975).
2. Takeda M., Takagi T., Yoshida Y., Maeno H., Arzneim. Forsch., 32(II), 734-737 (1982).
3. Tarunami M., Sakuma H., Shiratsuchi K., Mieda M., Arzneim. Forsch., 35(I), 703-706 (1985).
4. Bradshaw J., Brittan R. T., Clitherow J. W., Daly M. J., Jack D., Price B, J., Stables R., Br. J. Pharmacol., 66, 464 (1979).
5. Yellin T. O., Buck S. H., Oilman D. J., Jones D. F., Waldleworth J. M., Life Sci., 25, 2001-2009 (1979).
6. Blakemore R. C., Brown T. H., Durant G. J., Emmett J. C., Ganellin C. R., Parson M. E., Rasmussen A. C., Br. J. Pharmacol., 70, 105 (1980).
7. Cavanugh R. L., Usakewiez J. J., Buyniski J. P., J. Pharmacol. Exp. Ther., 224, 171-179 (1983).
8. Black J. W., Duncan W. A. M., Emmett J. C., Ganellin C. R., Hesselbo T., Parsons M. E., Wyllie J. H., Agents and Actions., 3, 133-137 (1973).
9. Dronfield M. W., Batchelor A. J., Larkworthy., Langman M. J. S., Gut 20, 526-539 (1979).
10. Martin D. F., Hollanders D., May S. J., Ravenscroft M. M., Tweedle D. E., Miller J. P., Lancet. 1, 7-10 (1981).
11. Rune S. J., Greibe L., Mollman H. R., Madsen J. R., Rahbek I., Willumsen L., Wilf H. R., Gut, 21, 151-153 (1980).
12. Burhan I, G., H. B. Matthews., Robert R. M., Gastroenterology, 92, 106-111 (1987).
13. Morita T., Yoshino K., Kanazawa T., Ito K., Nose T., Arzneim. Forsch., 32(II), 1037-1042 (1982).
14. Studies on FRG-8813, a compound structurally analogous to KRG-8701 (referred to in the following article in this journal) arc in progress. Onodera S., Shibata M., Tanaka M., Inaba N., Yamaura T., Ohnisi H., Jpn. J. Pharmacol., 68, 161-173 (1995).
15. Shibata M., Yamaura T., Sekine A., Nishikawa M., Chida Y., Ohnisi H., Jpn. J. Pharmacol., 54, 277-285 (1990).
16. Ghosh M. N., Schild H. O., Br. J. Phamacol., 13, 54-61 (1958).