Direct enantiomeric separation of mianserin and 6-azamianserin derivatives using chiral stationary phases

Journal of Chromatography A

Volumn 803, Issue 1-2, 1998, Pages 169-177

  Selditz, Ulrike ^a   Liao, Yi ^b   Franke, Jan Piet ^a   De Zeeuw, Rokus A ^a   Wikström, Håkan ^b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

6 Azamianserin; Chiral stationary phases, LC; Enantiomer separation; Mianserin

Indexed keywords

MIANSERIN; MIRTAZAPINE;

ARTICLE; DRUG DETERMINATION; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPOPHILICITY; PRIORITY JOURNAL;

EID: 0031967615     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(97)01288-0     Document Type: Article

References (33)

1. Okamoto Y., Kawashima M., Hatada K. J. Chromatogr. 363:1986;173.
2. Pirkle W.H., Finn J.M., Schreiner J.L., Hamper B.C. J. Am. Chem. Soc. 103:1981;3964.
3. Armstrong D.W., DeMond W. J. Chromatogr. Sci. 22:1984;411.
4. Armstrong D.W., Liu Y., Ekborgott K.H. Chirality. 7:1995;474.
5. Terfloth G.J., Pirkle W.H., Lynam K.G., Nicolas E.C. J. Chromatogr. A. 705:1995;185.
6. Allenmark S., Andersson S., Möller P., Sanchez D. Chirality. 7:1995;248.
7. Hand T.H., Marek G.J., Seiden L.S. Psychopharmacology. 105:1991;453.
8. Fink M., Irwin P. Psychopharmacology. 78:1982;44.
9. Smith W.T., Glaudin V., Panagides J., Gilvary E. Psychopharmacol. Bull. 20(2):1990;191.
10. Wood M.D., Thomas D.R., Watkins C.J., Newberry N.R. J. Pharm. Pharmacol. 45:1993;711.
11. Nickolson V.J., Wieringa J.H. J. Pharm. Pharmacol. 33:1981;760.
12. Gower A.J., Broekkamp C.L.E., Rijk H.W., van Delft A.M.L. Arch. Int. Pharmacodyn. Ther. 291:1988;185.
13. de Boer T., Maura G., Raiteri M., de Vos C.J., Wieringa J.H., Pinder R.M. Neuropharmacology. 27(4):1988;399.
14. de Jongh G.D., van den Wildenberg H.M., Nieuwenhuyse H., van der Veen F. Drug Metab. Disp. 9:1981;48.
15. Eap C.B., Powell K., Campus-Souche D., Monney C., Baettig D., Taeschner W., Baumann P. Chirality. 6:1994;555.
16. Heinig R., Delbressine L.P.C., Kaspersen F.M., Blaschke G. Arzneim.-Forsch./Drug Res. 43(7):1993;709.
17. Sonesson C., Boije M., Svensson K., Ekman A., Carlsson A., Romero A.G., Martin I.J., Duncan J.N., King L.J., Wikström H. J. Med. Chem. 36(22):1993;3409.
18. 1D receptor ligands, Thesis, State University of Groningen, 1996.
19. Chankvetadze B., Endresz G., Bergenthal D., Blaschke G. J. Chromatogr. A. 717:1995;245.
20. Y. Liao, U. Selditz, R.A. de Zeeuw, H. Wikström, Enantiomer (1997) in press.
21. R.F. Rekker, R. Mannhold, in: H.-J. Kraus (Ed.), Calculation of Drug Lipophilicity. The Hydrophobic Fragmental Constant Approach, Weinheim, New York, Basel, Cambridge, VCH, 1992.
22. Witte D.T., Bruggeman F.J., Franke J.P., Copinga S., Jansen J.M., de Zeeuw R.A. Chirality. 5:1993;545.
23. Roussel C., Popescu C. Chirality. 6:1994;251.
24. Roussel C., Popescu C., Shibata T. J. Chromatogr. A. 722:1996;177.
25. PALLAS 1.2 (computer program) version 1.2. CompuDrug Chemistry Limited, Budapest, Hungary, 1994.
26. Pirkle W.H., Welch C.J. J. Liq. Chromatogr. 14(11):1991;2027.
27. Cantrell G.O., Stringham R.W., Blackwell J.A., Weckwerth J.D., Carr P.W. Anal. Chem. 68(20):1996;3645.
28. Wainer I.W., Alembik M.C., Smith E. J. Chromatogr. 388:1987;65.
29. Brügger R., Arm H. J. Chromatogr. 592:1992;309.
30. Pirkle W.H., Readnour R.S. Chromatographia. 31(3/4):1991;129.
31. Bij K.E., Horvath C., Melander W.R., Nahum A. J. Chromatogr. 203:1981;65.
32. Kunath A., Theil F., Jähnisch K. J. Chromatogr. A. 728:1996;249.
33. S. Hauptmann (Ed.), Organische Chemie, 2nd ed., VEB Deutscher Verlag fur Grundstoffindustrie, Leipzig, 1988.