Hypofunction in the posterior cingulate gyrus correlates with disorientation for time and place in Alzheimer's disease

Journal of Neurology Neurosurgery and Psychiatry

Volumn 64, Issue 4, 1998, Pages 552-554

  Hirono, Nobutsugu ^a,b   Mori, Etsuro ^a   Ishii, Kazunari ^a   Ikejiri, Yoshitaka ^a   Imamura, Toru ^a   Shimomura, Tatsuo ^a   Hashimoto, Mamoru ^a   Yamashita, Hikari ^a   Sasaki, Masahiro ^a  

^a Institute for Aging Brain and Cognitive Disorders   (Japan)

^b Hyogo Institute for Aging Brain and Cognitive Disorders   (United States)

Author keywords

Alzheimer's disease; Orientation; Posterior cingulate gyrus

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN METABOLISM; CINGULATE GYRUS; CORRELATION FUNCTION; DISEASE SEVERITY; DISORIENTATION; FEMALE; GLUCOSE METABOLISM; HUMAN; MAJOR CLINICAL STUDY; MALE; ORIENTATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; TIME PERCEPTION;

EID: 0031967611     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.64.4.552     Document Type: Article

References (17)

1. Fisher CM. Disorientation for place. Arch Neurol 1982;39:33-6.
2. Spiegel EA, Wycis HT, Orchinik CW, et al. The thalamus and temporal orientation. Science 1955;121:771-2.
3. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-44.
4. Hughes CP, Berg L, Danziger WL, et al. A new clinical scale for the staging of dementia. Br J Psychiatry 1982;140:566-72.
5. Folstein MF, Folstein SE, McHugh PR. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98
6. Mohs RC, Rosen WG, Davis KL. The Alzheimer's disease assessment scale; an instrument for assessing treatment efficacy. Psychopharmacol Bull 1983;19:448-50.
7. Ishii K, Sasaki M, Kitagaki H, et al. Reduction of cerebellar glucose metabolism in advanced Alzheimer's disease. J Nucl Med 1997;38:925-8
8. Kitagawa Y, Meyer JS, Tachibana H, et al. CT-CBF correlations of cognitive deficits in multi-infarct dementia. Stroke 1984;15:1000-9.
9. Takahashi N, Kawamura M, Shiota J, et al. Pure topographic disorientation due to right retrosplenial lesions. Neurology 1997;49:464-9
10. Posner MI. Attention in cognitive neuroscience: an overview. In: Gazzaniga MS, eds. The cognitive neurosciences. Cambridge: MIT, 1995:615-24
11. Vogt BA, Finch DM, Olson CR. Functional heterogeneity in cingulate cortex: the anterior executive and posterior evaluative regions. Cereb Cortex 1992;2:435-43.
12. Sutherland RJ, Whishaw IQ, Kolb B. Contributions of cingulate cortex to two forms of spatial learning and memory. J Neurosci 1988;8:1863-72.
13. Murray EA, Davidson M, Gaffan D, et al. Effects of fornix transection and cingulate cortical ablation on spatial memory in rhesus monkeys. Exp Brain Res 1989;74:173-86.
14. Markowska AL, Olton DS, Murray EA, et al. A comparative analysis of the role of fornix and cingulate cortex in memory: rats. Exp Brain Res 1989;74:187-201.
15. 15O positron emission tomography. Eur J Nucl Med 1997;24:670-3
16. Minoshima S, Giordani B, Berent S, et al. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 1997;42:85-94.
17. Levin HS, Benton AL. Temporal orientation in patients with brain disease. Appl Neurophysiol 1975;38:56-60.