Effect of experimental diabetes mellitus on gentamicin-induced acute renal functional changes in the anaesthetized rat

Clinical and Experimental Pharmacology and Physiology

Volumn 25, Issue 3-4, 1998, Pages 231-235

  Hamilton, K ^a   Eaton, E J ^a   Garland, H O ^a   Old, S ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Calcium; Diabetes mellitus; Gentamicin; Kidney; Nephrotoxicity

Indexed keywords

GENTAMICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM EXCRETION; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; HYPERCALCIURIA; KIDNEY CLEARANCE; KIDNEY INJURY; MALE; NEPHROTOXICITY; NONHUMAN; RAT; STREPTOZOCIN DIABETES;

EID: 0031966397     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1998.t01-8-.x     Document Type: Article

References (29)

1. Bennelt WM. Mechanisms of aminoglycoside nephrotoxicity. Clin. Exp. Phannacol. Physiol. 1989; 16: 1-6.
2. Kacew S, Bergeron MG. Pathogenic factors in aminoglycoside-induced nephrotoxicity. Toxicol. Lett. 1990; 51: 241-59.
3. Teixeira RB, Kelley J, Alpert H, Pardo V, Vaamonde CA. Complete protection from gentamicin-induced acute renal failure in the diabetes mellitus rat. Kidney Int. 1982; 21: 600-12.
4. Cronin RE, Splinter KL, Ferguson ER, Heinrich WL. Gentamicin nephrotoxicity: Protective effect of diabetes on cell injury. Miner. Electrolyte Metab. 1983; 9: 38-44.
5. Vaamonde CA, Bier RT, Gouvea W, Alpert H, Kelley J, Pardo V. Effect of duration of diabetes on the protection observed in the diabetic rat against gentamicin-induced acute renal failure. Miner. Electrolyte Metab. 1984; 10: 209-16.
6. Elliott WC, Houghton DC, Gilbert DN, Baines-Hunter J, Bennett WM. Experimental gentamicin nephrotoxicity: Effect of streptozotocininduced diabetes. J. Pharmacol. Exp. Ther. 1985; 233: 264-70.
7. Gouvea WL, Alpert HC, Kelley J, Pardo V, Vaamonde CA. Phlorizininduced glycosuria does not prevent gentamicin nephrotoxicity in rats. Kidney Int. 1989; 35: 1041-8.
8. Gouvea WL, Roth D, Alpert HC, Kelley J, Pardo V, Vaamonde CA. Insulin reverses the protection given by diabetes against gentamicin nephrotoxicity in the rat. Proc. Soc. Exp. Biol. Med. 1994; 206:445-53.
9. Elliott WC, Patchin DS. Aminoglycoside-mediated calciuresis. J. Pharmacol. Exp. Ther. 1992; 61: 151-6.
10. Foster JE, Harpur ES, Garland HO. Investigation of the acute effect of gentamicin on the renal handling of electrolytes in the rat. J. Phannacol. Exp. Ther. 1992; 261: 38-13.
11. Garland HO, Birdsey TJ, Davidge CG et al. Effects of gentamicin, neomycin and tobramycin on renal calcium and magnesium handling in two rat strains. Clin. Exp. Pharmacol. Physiol. 1994; 21: 109-15.
12. Garland HO, Phipps DJ, Harpur ES. Gentamicin-induced hypercalciuria in the rat: Assessment of nephron site involved. J. Phannacol. Exp. Ther. 1992; 263: 293-7.
13. Harpur ES, Fathalla SAK, Phipps DJ. Increased urinary excretion of calcium and magnesium is an early manifestation of gentamicin-induced nephrotoxicity in the rat. In: Bach PH (ed.). Renal Heterogeneity and Target Cell Toxicity. John Wiley & Sons, Chichester. 1985; 349-52.
14. Hamilton K, Eaton EJ, Garland HO, Old S. Experimental diabetes mellitus does not alter gentamicin-induced acute renal functional changes in the rat. Hum. Exp. Toxicol. 1994; 13: 289.
15. Hough S, Russell JE, Teitelbaum SL, Avioli LV. Calcium homeostasis in chronic streptozotocin-induced diabetes mellitus in the rat. Am. J. Physiol. 1982; 242: E451-6.
16. Wood RJ, Allen LH, Bronner F. Regulation of calcium metabolism in streptozotocin-induced diabetes. Am. J. Physiol. 1984; 247: R120-3.
17. Guruprakash GH, Krothapalli RK, Rouse D, Babino H, Suki WN. The mechanism of hypercalciuria in streptozotocin-induced diabetic rats. Metabolism 1988; 37: 306-11.
18. Anwana AB, Garland HO. Renal calcium and magnesium handling in experimental diabetes mellitus in the rat. Acta Endocrinol. 1990; 122: 479-86.
19. Garland HO, Harris PJ, Morgan TO. Calcium transport in the proximal convoluted tubule and loop of Henle of rats made diabetic with streptozotocin. J. Endocrinol. 1991; 131: 373-80.
20. Hebden RA, Gardiner SM, Bennett T, MacDonald IA. The influence of streptozotocin-induced diabetes mellitus on fluid and electrolyte handling in rats. Clin. Sei. 1986; 70: 111-17.
21. Garland HO, Freeman S, Bums C, Cusack M. Renal function in chronically catheterised conscious rats with experimental diabetes mellitus. J. Physiol 1990; 430: 80P.
22. Hamilton K, Garland HO, Balment RJ. Renal function in servocontrolled chronically catheterised conscious rats with diabetes mellitus. J. Physiol. 1995; 483P: P173.
23. Parsons PP, Garland HO, Harpur ES. Effect of gentamicin on urinary recovery of 45Ca from distal tubular microinfusions in the anaesthetised rat. J. Physiol. 1995; 483P: P168.
24. Anwana AB. Renal function in the streptozotocin-diabetic rat. PhD thesis, University of Manchester, Manchester, UK. 1989.
25. Bennett WM, Elliott WC, Houghton DC, Gilbert DN, de Fehr J, McCarron DA. Reduction of experimental gentamicin nephrotoxicity in rats by dietary calcium loading. Antimicrob. Agents Chemother. 1982; 22: 508-12.
26. Humes HD, Sastrasinh M, Weinberg JM. Calcium is a competitive inhibitor of gentamicin-renal membrane binding interactions and dietary calcium supplementation protects against gentamicin nephrotoxicity. J. Clin. Invest. 1984; 73: 134.
27. Quarum ML, Houghton DC, Gilbert DN, McCarron DA, Bennett WM. Increasing dietary calcium moderates experimental gentamicin nephrotoxicity. J. Lab. Clin. Med. 1984; 103: 104-14.
28. Bennett WM, Pulliam JP, Porter GA, Houghton DC. Modification of experimental gentamicin nephrotoxicity by selective parathyroidectomy. Am. J. Physiol. 1985; 249: F832-5.
29. +-ATPase activity and other renal functional changes. Acta Physiol. Scand. 1992; 145: 93-8.