Synthesis and structure-antibacterial activity relationships of 7-(3- amino-1-propynyl and 3-amino-1-propenyl)quinolones

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 4, 1998, Pages 631-638

  Fujita, Masahiro ^a   Chiba, Katsumi ^a   Nakano, Junji ^a   Tominaga, Yukio ^a   Matsumoto, Jun Ichi ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Antibacterial activity; Bioisostere; Computer aided molecular modeling; Cross coupling reaction; Quinolone; Structure activity relationship

Indexed keywords

7 (3 AMINO 1 PROPENYL) 1 CYCLOPROPYL 6,8 DIFLUORO 1,4 DIHYDRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 7 (3 AMINO 1 PROPYL) 1 CYCLOPROPYL 6,8 DIFLUORO 1,4 DIHYDRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 7 (3 AMINO 1 PROPYNYL) 1 CYCLOPROPYL 6,8 DIFLUORO 1 ,4 DIHYDRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; ANTIBIOTIC AGENT; CIPROFLOXACIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; COMPUTER MODEL; CONFORMATIONAL TRANSITION; DRUG CONFORMATION; DRUG POTENCY; DRUG SYNTHESIS; HYDROGENATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 0031965720     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.631     Document Type: Article

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