The antineoplastic ether lipid, s-phosphonate, selectively induces apoptosis in human leukemic cells and exhibits antiangiogenic and apoptotic activity on the chorioallantoic membrane of the chick embryo

Cancer Chemotherapy and Pharmacology

Volumn 41, Issue 4, 1998, Pages 326-332

  Jackson, John K ^a   Burt, Helen M ^a   Oktaba, Ann Marie ^a,b   Hunter, William ^b   Scheid, Michael P ^a   Mouhajir, Fatima ^a   Lauener, Ron W ^a   Shen, Yaping ^c   Salari, Hassan ^a,c   Duronio, Vincent ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Angiogenesis Technologies Inc   (Canada)

^c Inflazyme Pharmaceuticals Ltd   (Canada)

Author keywords

Antiangiogenesis; Apoptosis; S phosphonate

Indexed keywords

ANGIOGENESIS INHIBITOR; DNA FRAGMENT; ETHER LIPID; POLYCAPROLACTONE; POLYMER; S PHOSPHONATE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CHICK EMBRYO; CHORIOALLANTOIS; CYTOTOXICITY; LEUKEMIA CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CHICK EMBRYO; CHORION; HL-60 CELLS; HUMANS; LEUKEMIA; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHOLIPIDS; PHOSPHONIC ACIDS; TUMOR CELLS, CULTURED;

EID: 0031965190     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050746     Document Type: Article

References (26)

1. Paltauf F (1994) Ether lipids in biomembranes. Chem Phy Lipids 74: 101-139
2. Bittman R, Byun HS, Mercier B, Salari H (1993) 2′-(trimethylammonio)ethyl 4-(hexadecyloxy)-3(5)-methyoxybutane phosphonate: a novel potent antineoplastic agent. J Med Chem 36: 297-299
3. Diomede L, Piovani B, Re F, Principe P, Colotta F, Modest E, Salmona M (1994) The induction of apoptosis is a common feature of the cytotoxic action of ether-linked glycerophospholipids in human leukemic cells. Int J Cancer 57: 645-649
4. 3. Cancer Chemother Pharmacol 34: 175-178
5. Auerbach R, Alby L, Morrissey LW, Tu M, Joseph J (1985) Expression of organ-specific antigens on capillary endothelial cells. Microvasc Res 29: 401-411
6. Folkman J, Hochberg M (1973) Self regulation of growth in three dimensions. J Exp Med 138: 745-753
7. 3. Biochem Biophys Res Commun 192: 603-609
8. Diomede L, Colotta F, Piovani B, Re F, Modest EJ, Salmona M (1993) Induction of apoptosis in human leukemic cells by the ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine. A possible basis for its selective action. Int J Cancer 53: 124-130
9. Mollinedo F, Gajate C, Modelell M (1993) The ether lipid 1-octadecyl-2-methyl-rac-glycero-3-phosphochloline induces expression of fos and jun proto-oncogenes and activates AP-1 transcription factor in human leukaemic cells. Biochem J 302: 325-329
10. Jackson JK, Burt HM, Mok W, Salari H, Kumar ER, Byun HS, Bittman R (1994) A comparison of the lytic properties of two ether linked lipids, one with and one without antineoplastic activity. Biochem Cell Biol 72: 297-303
11. Paul CC, Tolbert M, Mahrer S, Singh A (1993) Cooperative effects of interleukin-3 (IL-3), IL-5, and granulocyte-macrophage colony-stimulating factor: a new myeloid cell line inducible to eosinophils. Blood 81: 1193-1199
12. Scheid MP, Lauener R, Duronio V (1995) Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor. Biochem J 312: 159-162
13. Scudiero DA, Shoemaker RH, Paull KD, Monks A, Tierney S, Nofziger TH, Currens MJ, Seniff D, Boyd MR (1988) Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res 48: 4827-4833
14. Hamburger V (1960) A manual of experimental embryology. University of Chicago Press, Chicago
15. Modolell M, Andressen R, Pahlke W, Brugger U, Munder PG (1979) Disturbance of phospholipid metabolism during the selective destruction of tumor cells induced by alkyl-lysophospholipids. Cancer Res 39: 4681-4686
16. Berdel WE (1991) Membrane-interactive lipids as experimental anticancer drugs. Br J Cancer 64: 208-211
17. Vogler WR, Berdel WE, Olson AC, Winton EF, Heffner LT, Gordon DS (1992) Autologous bone marrow transplantation in acute leukemia with marrow purged with alkyl-lysophospholipid. Blood 80: 1423-1429
18. Andreeesen R, Modelell M, Weltzien HU, Eibl H, Common HH, Lohr GW, Munder PG (1978) Selective destruction of human leukemic cells by alkyl-lysophospholipids. Cancer Res 38: 3894-3899
19. Berdel WE, Greiner E, Fink U, Stavrou D, Reichert A, Rastetter J, Hoffman DR, Snyder F (1983) Cytotoxicity of alkyl-lysophospholipid derivatives and low-alkyl-cleavage enzyme activities in rat brain tumor cells. Cancer Res 43: 541-545
20. Wilcox RW, Wykle RW, Schmitt JD, Daniel LW (1987) The degradation of platelet-activating factor and related lipids: susceptibility to phospholipases C and D. Lipids 22: 800-807
21. Hoffman DR, Hoffman LH, Snyder F (1986) Cytotoxicity and metabolism of alkyl phospholipid analogues in neoplastic cells. Cancer Res 46: 5803-5809
22. Kelley EE, Modest EJ, Burns CP (1993) Unidirectional membrane uptake of the ether lipid antineoplastic agent edelfosine by L1210 cells. Biochem Pharmacol 45: 2435-2439
23. Diomede L, Piovani B, Modest EJ, Salmona M (1993) The effect of culture medium composition on ether lipid cytotoxic activity. Lipids 28: 189-192
24. Berggren MI, Gallegos A, Dressler LA, Modest EJ, Powis G (1993) Inhibition of the signalling enzyme phosphatidylinositol-3-kinase by antitumor ether lipid analogues. Cancer Res 53: 4297-4302
25. Dordunoo SK, Jackson JK, Arsenault LA, Oktaba AMC, Hunter WL, Burt HM (1995) Taxol encapsulation in poly(E-Caprolactone) microspheres. Cancer Chemother Pharmacol 36: 279-282
26. Folkman J, Klagsbrun M (1987) Angiogenic factors. Science 235: 442-447