Retroviral transduction of human CD34+ umbilical cord blood progenitor cells with a mutated dihydrofolate reductase cDNA

Human Gene Therapy

Volumn 9, Issue 1, 1998, Pages 63-71

  Flasshove, Michael ^b   Banerjee, Debabrata ^a   Leonard, John P ^a   Mineishi, Shin ^c   Li, Ming Xia ^d   Bertino, Joseph R ^a   Moore, Malcolm A S ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c WYETH RESEARCH   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; COMPLEMENTARY DNA; DIHYDROFOLATE REDUCTASE; INTERLEUKIN 1; INTERLEUKIN 3; METHOTREXATE; STEM CELL FACTOR; VIRUS DNA;

ARTICLE; CELL CYCLE S PHASE; COCULTURE; COLONY FORMING UNIT GM; CONTROLLED STUDY; DNA INTEGRATION; DRUG RESISTANCE; GENE TRANSFER; GENETIC TRANSDUCTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; NONHUMAN; POLYMERASE CHAIN REACTION; PROVIRUS; RETROVIRUS; UMBILICAL CORD BLOOD;

EID: 0031964990     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.1-63     Document Type: Article

References (3)

1. 34 mutant human dihydrofolate reductase into Chinese hamster ovary and mouse marrow progenitor cells confers methotrexate resistance. Gene 139, 269-276.
2. WILLIAMS, D.A., LEMISCHKA, I.R., NATHAN, D.G., and MULLIGAN, R.C. (1984). Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse. Nature 310, 476-480.
3. WILLIAMS, D.A., HSIEH, K., DESILVA, A., and MULLIGAN, R.C. (1987). Protection of bone marrow transplant recipients from lethal doses of methotrexate by the generation of methotrexate-resistant bone marrow. J. Exp. Med. 166, 210-218.