Quantitation of dolastatin-10 using HPLC/electrospray ionization mass spectrometry: Application in a phase I clinical trial

Cancer Chemotherapy and Pharmacology

Volumn 41, Issue 4, 1998, Pages 299-306

  Garteiz, D A ^b   Madden, T ^a   Beck, D E ^a   Huie, W R ^a   McManus, K T ^b   Abbruzzese, J L ^a   Chen, W ^a   Newman, R A ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b TEXms Inc   (United States)

Author keywords

Dolastatin 10; Dolastatin 15; Liquid chromatography atmospheric pressure; Mass spectrometry; Phase I trial

Indexed keywords

DOLASTATIN 10; DOLASTATIN 15; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BLOOD ANALYSIS; BOLUS INJECTION; CLINICAL TRIAL; CONTROLLED STUDY; DRUG DETERMINATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MASS SPECTROMETRY; PHARMACOKINETICS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; ATMOSPHERIC PRESSURE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEPSIPEPTIDES; HUMANS; MASS SPECTROMETRY; NEOPLASMS; OLIGOPEPTIDES; REFERENCE STANDARDS; TISSUE DISTRIBUTION;

EID: 0031964631     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050743     Document Type: Article

References (18)

1. Pettit GR, Kamano K, Herald CL, Tuinman AA, Boettner FE, Kizu H, Schmidt JM, Bacztnskyi L, Tomer KB, Bontems RJ (1987) The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin-10. J Am Chem Soc 109: 6883
2. Pettit GR, Singh SB, Hogan F, Lloyd-Williams P, Herald DL, Burkett DD, Clewlow PJ (1989) The absolute configuration and synthesis of natural (-)dolastatin-10. J Am Chem Soc 111: 5463
3. Bai R, Pettit GR, Hamel E (1990) Dolastatin-10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain. Biochem Pharmacol 39: 1941
4. Jacobsen SEW, Ruscetti FW, Longo DL, Keller JR (1991) Antineoplastic dolastatins: potent inhibitors of hematopoietic progenitor cells. J Natl Cancer Inst 83: 1672
5. Steube KG, Grunicke D, Pietsch T, Gignac SM, Pettit GR, Drexler HG (1992) Dolastatin-10 and dolastatin-15: effects of two natural peptides on growth and differentiation of leukemia cells. Leukemia 6: 1048
6. Hu ZB, Gignac SM, Quentmeier H, Pettit GR, Drexler HG (1993) Effects of dolastatins on human B-lymphocytic leukemia cell lines. Leukemia Res 17: 333
7. Beckwith B, Urba WJ, Longo DL (1993) Growth inhibition of human lymphoma cell lines by the marine products dolastatins 10 and 15. J Natl Cancer Inst 85: 483
8. Pettit GR, Kamano Y, Herald L, Fujii Y, Kizu H, Boyd MR, Boettner FE, Doubek DL, Schmidt JM, Hapuis JC, Michel C (1993) Isolation of dolastatins 10-15 from the marine mollusc Dolabella auricularia. Tetrahedron 49: 9151
9. Bai R, Pettit GR, Hamel E (1990) Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10. Biochem Pharmacol 40: 1859
10. Bai R, Roach MC, Jayaram SK, Barkoczy J, Pettit GR, Luduena RF, Hamel E (1993) Differential effects of active isomers, segments and analogs of dolastatin-10 on ligand interactions with tubulin. Correlation with cytotoxicity. Biochem Pharmacol 45: 1503
11. D'Argenio DZ, Schmitzky A (1979) A program package for simulation and parameter estimation in pharmacokinetic systems. Comput Programs Biomed 9: 115
12. Gibaldi M, Perrier D (1982) Pharmacokinetics. Marcel Dekker, New York, pp 92-109
13. Aherne W, Hardcastle A, Valenti M, Bryant A, Rogers P, Srirangam JK, Pettit GR, Kelland LR (1995) In vitro and in vivo antitumor evaluation of dolastatin (Dol) 10 and 15 and their measurement in plasma by radioimmunoassay (RIA). Proc Am Assoc Cancer Res 36: 385
14. Huie WR, Madden T, Newman RA (1997) High-performance capillary electrophoresis measurement of dolastatin-10. J Chromatogr B (in press)
15. Pettit GR, Kantoci D, Herald DL, Barkoczy J, Slack JA (1994) Procedures for the analyses of dolastatins 10 and 15 by high performance liquid chromatography. J Liq Chromatogr 17: 191
16. Reid JM, Walker DL, Ames MM (1995) Evaluation of an L1210 bioassay and HPLC for determination of dolastatin 10 in human and murine plasma. Proc Am Assoc Cancer Res 36: 364
17. Miyazaki S, Kobayashi M, Natsume T, Gondo M, Mikami T, Sakakibara K, Tsukagoshi S (1995) Synthesis and antitumor activity of novel dolastatin 10 analogues. Chem Pharm Bull 43: 1076
18. Bai R, Fredman SJ, Pettit GR, Hamel E (1992) Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella uricularia. Interaction with tubulin and effects on cellular microtubules. Biochem Pharmacol 43: 2637