Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute-phase protein responses in patients undergoing cardiac surgery

Acta Anaesthesiologica Scandinavica

Volumn 42, Issue 1, 1998, Pages 63-70

  Brix Christensen, V ^a   Tonnesen E ^b   Sorensen I J ^b   Bilfinger, T V ^b   Sanchez, R G ^b   Stefano, G B ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NONE

Author keywords

Anesthetics, epidural, intravenous: fentanyl; Immune response: cytokines, acute phase proteins; Surgery: cardiac

Indexed keywords

ACUTE PHASE PROTEIN; AMYLOID P COMPONENT; BUPIVACAINE; C REACTIVE PROTEIN; CYTOKINE; ENFLURANE; FENTANYL; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; MIDAZOLAM; MORPHINE; NARCOTIC AGENT;

ACUTE PHASE RESPONSE; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DOSE RESPONSE; DRUG MEGADOSE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDURAL DRUG ADMINISTRATION; HUMAN; IMMUNOELECTROPHORESIS; INFLAMMATION; INHALATION ANESTHESIA; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; PRIORITY JOURNAL; THORAX EPIDURAL ANESTHESIA;

EID: 0031964356     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-6576.1998.tb05082.x     Document Type: Article

References (29)

1. Tønnesen E. Immunological aspects of anesthetic management. Adv Neuroimmunol 1994: 3: 255-267.
2. Knudsen F, Andersen LW. Immunological aspects of cardiopulmonary bypass. J Cardiothorac Anesth 1990: 4: 245-258.
3. SaLo M. Effects of anaesthesia and surgery on the immune response. Acta Anaesthesiol Scand 1990: 4: 245-258.
4. Bendtzen K, Hansen MB, Svenson M. Modulation of inflammatory cytokines by a receptor antagonist, autoantibodies, and fever. Comb Therapies 1993: 3: 123-133.
5. Tønnesen E, Brix-Christensen V, Toft P. The role of cytokines in cardiac surgery. Int J Cardiol 1996: 53: 1-10.
6. McBride WT, Armstrong MA, Crockard AD, McMurray TJ, Rea JM. Cytokine balance and immunosuppressive changes at cardiac surgery: contrasting response between patients and isolated CPB circuits. Br J Anaesth 1995: 75: 724-733.
7. Chernoff AE, Granowitz EV, Shapiro L et al. A randomized, controlled trial of IL-10 in humans. J Immunol 1995: 154: 5492-5499.
8. Stefano GB, Smith EM. Adrenocorticotropin - A central trigger in immune responsiveness: Tonal inhibition of immune activation. Med Hypotheses 1996: 46: 471-478.
9. Yeager MP, Colacchio TA, Yu CT et al. Morphine inhibits spontaneous and cytokine enhanced natural killer cell cytotoxicity in volunteers. Anesthesiology 1995: 83: 500-508.
10. Beilin B, Shavit Y, Hart J et al. Effects of anesthesia based on large versus small doses of fentanyl on natural killer cell cytotoxicity in the perioperative period. Anesth Analg 1996: 82: 492-497.
11. Crozier TA, Müller JE, Quittkat D, Sydow M, Wuttke W, Kettler D. Effect of anaesthesia on the cytokine responses to abdominal surgery. Br J Anaesth 1994: 72: 280-285.
12. Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. J Biol Chem 1990: 265: 621-636.
13. Anderson JK, Mole JE. Large scale isolation and partial primary structure of human plasma amyloid P-component. Ann N Y Acad Sci 1982: 389: 216-234.
14. Sørensen IJ, Andersen O, Holm Nielsen E, Svehag S-E. Multiple isoforms of the human pentraxin serum amyloid P-component. Int Arch Allergy Immunol 1995: 106: 25-31.
15. Skinner M, Vaitukaitis JL, Cohen AS et al. Serum amyloid P-component levels in amyloidosis, connective tissue diseases, infection, and malignancy as compared to normal serum. J Lab Clin Med 1979: 97: 633-638.
16. Pepys MB, Dash AC, Markham RE et al. Comparative clinical study of protein SAP (amyloid P component) and C-reactive protein in serum. Clin Exp Immunol 1978: 32: 119-124.
17. Migata S. Human serum amyloid P-component (SAP) as an acute phase reactant in females. Proceeding at the 4th International Symposium on Amyloisdosis: The Disease Complex, November 9-12. New York: Colombia University, 1986: 87-97.
18. Stefano GB, Bilfingr TV. Human neutrophil and macrophage chemokinesis induced by cardiopulmonary bypass: loss of DAME and IL-1 chemotaxis. J Neuroimmunol 1993: 47: 189-198.
19. Stefano GB, Rodriquez M, Glass R, Cesares F, Hughes TK, Bilfinger TV. Hyperstimulation of leucocytes by plasma from cardiopulmonary by-pass patients is diminished by morphine and IL-10 pretreatment. J Cardiovasc Surg 1995: 36: 25-30.
20. Stefano GB, Kushnerik V, Roderiques M, Bilfinger TV. Inhibitory effect of morphine on granulocyte stimulation by tumor necrosis factor and substance P. Int J Immunopharmacol 1994: 16: 329-334.
21. Stefano GB, Leung MK, Bilfinger TV, Scharrer B. Effect of prolonged exposure to morphine on responsiveness of human and invertebrate immunocytes to stimulatory molecules. J Neuroimmunol 1995: 63: 175-181.
22. Moore CM, Desborough JP, Powell H, Burrin JM, Hall GM. Effects of extradural anaesthesia on interleukin-6 and acute phase response to surgery. Br J Anaesth 1994: 72: 272-279.
23. Naito Y, Tamai S, Shingu K et al. Response of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. Anesthesiology 1992: 77: 426-431.
24. Stenseth R, Bjella L, Berg EM et al. Thoracis epidural analgesia in aortocoronary bypass surgery II: effects on the endocrine metabolic response. Acta Anaesthesiol Scand 1994: 38: 834-839.
25. Doughty LA, Kaplan SS, Carcillo JA. Inflammatory cytokine and nitric oxide responses in pediatric sepsis and organ failure. Crit Care Med 1996: 24: 1137-1143.
26. Tønnesen E, Hansen MB, Höhndorf K et al. Cytokines in plasma and ultrafiltrate during continuous arteriovenous haemofiltration. Anaesth Intensive Care 1993: 21: 752-758.
27. Marchand A, Deviere J, Byl B, De Groot D, Vincent JL, Goldman M. Interleukin production during septicaemia. Lancet 1994: 343: 707-708.
28. Ohzato H, Yoshizaki K, Nishimoto N et al. Interleukin-6 is a new indicator of inflammatory status: detection of serum levels of interleukin-6 and C-reactive protein after surgery. Surgery 1992: 111: 201-209.
29. Oka Y, Murata A, Nishijima J et al. Circulating interleukin 6 as a useful marker for predicting postoperative complications. Cytokine 1992: 4: 298-304.