Lung delivery of non-CFC salbutamol via small volume metal spacer and large volume plastic spacer devices compared with an open vent jet nebulizer

British Journal of Clinical Pharmacology

Volumn 45, Issue 2, 1998, Pages 160-163

  Lipworth, B J ^a   Clark, D J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Airomir; Lung delivery; NebuChamber; Nebuliser; Non CFC; Salbutamol; Sidestream; Spacer; Volumatic

Indexed keywords

SALBUTAMOL;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; HEART RATE; HUMAN; HUMAN EXPERIMENT; INHALATIONAL DRUG ADMINISTRATION; INHALER; METERED DOSE INHALER; NEBULIZER; NORMAL HUMAN; PHARMACOKINETICS; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; RESIDUAL VOLUME; SPACER; TREMOR; VOLUNTEER;

ADMINISTRATION, INHALATION; ADRENERGIC BETA-AGONISTS; ADULT; ALBUTEROL; CHLOROFLUOROCARBONS; CROSS-OVER STUDIES; DRUG DELIVERY SYSTEMS; HEART RATE; HUMANS; LUNG; LUNG VOLUME MEASUREMENTS; NEBULIZERS AND VAPORIZERS; POTASSIUM; SINGLE-BLIND METHOD; TREMOR;

EID: 0031963823     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1998.00648.x     Document Type: Article

References (17)

1. Jenkins SC, Heaton RW, Fulton TJ, Moxham J. Comparison of domiciliary nebulised salbutamol and salbutamol from a metered dose inhaler in stable chronic airflow limitation. Chest 1987; 91: 804-807.
2. Newhouse M, Dolovich M. Aerosol therapy: nebuliser vs metered dose inhaler. Chest 1987; 91: 799-800.
3. Noseda A, Yernault JC. Sympathomimetics in acute severe asthma: inhaled or parenteral, nebuliser or spacer? Eur Respir J 1989; 2: 377-382.
4. Konig P. Spacer devices used with metered dose inhalers. Breakthrough or gimmick? Chest 1985; 88: 276-284.
5. Loffert DT, Ikle D, Nelson H. A comparison of commercial jet nebulisers. Chest 1994; 106: 1788-1793.
6. Clark DJ, Lipworth BJ. Effect of multiple actuations, delayed inhalation and antistatic treatment on the lung bioavailability of salbutamol via a spacer device. Thorax 1996; 51: 981-984.
7. Barry PW, O'Callaghan CO. The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from a nebuhaler. Br J Clin Pharmacol 1995; 40: 76-78.
8. Bisgaard H, Anhoj J, Klug B, Berg E. A non-electrostatic spacer for aerosol delivery. Arch Dis Child 1995; 73: 226-230.
9. Wildhaber JH, Devadason SG, Eber E, et al. Effect of electrostatic charge, flow, delay and multiple actuations on the in vitro delivery of salbutamol from different small volume spacers for infants. Thorax 1996; 51: 985-988.
10. Lipworth BJ, Clark RA, Dhillon DP, et al. Pharmacokinetics, efficacy and adverse effects of sublingual salbutamol in patients with asthma. Eur J Clin Pharmacol 1989; 37: 567-571.
11. Chrystyn H, Corlett SA, Silkstone V. Lung bioavailability of generic and innovator salbutamol MDIs. Thorax 1996; 51: 658.
12. Lipworth BJ, Clark DJ. Lung delivery of salbutamol by dry powder inhaler (Turbuhaler) and small volume antistatic metal spacer (Airomir CFC-free MDI plus NebuChamber). Eur Respir J 1997; 10: 1820-1823.
13. Clark DJ, Gordon-Smith J, McPhate G, Clark G, Lipworth BJ. Lung bioavailability of generic and innovator salbutamol metered dose inhalers. Thorax 1996; 51: 325-326.
14. Clark DJ, Lipworth BJ. Lung bioavailability of chlorofluorocarbon free, dry powder and chlorofluorocarbon containing formulations of salbutamol. Br J Clin Pharmacol 1996; 41: 247-249.
15. Lipworth BJ, McDevitt DG. Beta-adrenoceptor responses to inhaled salbutamol in normal subjects. Eur J Clin Pharmacol 1989; 36: 239-245.
16. Colacone A, Afilalo M, Wolkove N, Kreisman H. A comparison of albuterol administered by metered dose inhaler (and holding chamber) or wet nebuliser in acute asthma. Chest 1993; 104: 835-841.
17. Idris A, McDermott M, Raucci J, Morrabel A, McGorray S, Hendeles L. Emergency department treatment of severe asthma. Chest 1993; 103: 665-672.