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Volumn 135, Issue 1, 1998, Pages 22-26

Inhibition of dextromethorphan metabolism by moclobemide

Author keywords

CYP2D6; Dextromethorphan; Drug interactions; Extensive metabolizer; Moclobemide; Poor metabolizer

Indexed keywords

ANTIDEPRESSANT AGENT; CYTOCHROME P450 ISOENZYME; DEXTROMETHORPHAN; MOCLOBEMIDE;

EID: 0031963544     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050481     Document Type: Article
Times cited : (21)

References (22)
  • 1
    • 0025729217 scopus 로고
    • Clinical consequences of polymorphic drug oxidation
    • Alván G (1991) Clinical consequences of polymorphic drug oxidation. Fundam Clin Pharmacol 5:209-228
    • (1991) Fundam Clin Pharmacol , vol.5 , pp. 209-228
    • Alván, G.1
  • 2
    • 33748901471 scopus 로고
    • Comparative pharmacology of levorphan, racemorphan, and dextrorphan and related methyl ethers
    • Benson WM, Stefko PL, Randall LO (1953) Comparative pharmacology of levorphan, racemorphan, and dextrorphan and related methyl ethers. J Pharmacol Exp Ther 109:189-200
    • (1953) J Pharmacol Exp Ther , vol.109 , pp. 189-200
    • Benson, W.M.1    Stefko, P.L.2    Randall, L.O.3
  • 3
    • 0028308622 scopus 로고
    • Dextromethorphan metabolism in rat: Interstrain differences and the fate of individually administered oxidative metabolites
    • Bochner F, Somogyi AA, Chen ZR (1994) Dextromethorphan metabolism in rat: interstrain differences and the fate of individually administered oxidative metabolites. Xenobiotica 24: 543-552
    • (1994) Xenobiotica , vol.24 , pp. 543-552
    • Bochner, F.1    Somogyi, A.A.2    Chen, Z.R.3
  • 4
    • 0025164236 scopus 로고
    • Short-lasting and reversible inhibition of monoamine oxidase-A by moclobemide
    • Da Prada M, Kettler R, Keller HH, Burkard WP (1990) Short-lasting and reversible inhibition of monoamine oxidase-A by moclobemide. Acta Psychiatr Scand 82 [Suppl 360]: 103-105
    • (1990) Acta Psychiatr Scand , vol.82 , Issue.360 SUPPL. , pp. 103-105
    • Da Prada, M.1    Kettler, R.2    Keller, H.H.3    Burkard, W.P.4
  • 7
    • 0026651273 scopus 로고
    • Human cytochromes P450: Problems and prospects
    • Gonzales FJ (1992) Human cytochromes P450: problems and prospects. Trends Pharmacol Sci 13:346-352
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 346-352
    • Gonzales, F.J.1
  • 8
    • 0027956791 scopus 로고
    • Characterization of dextromethorphan N-demethylation by human liver microsomes
    • Gorski JC, Jones DR, Wrighton SA, Hall SD (1994) Characterization of dextromethorphan N-demethylation by human liver microsomes. Biochem Pharmacol 48:173-182
    • (1994) Biochem Pharmacol , vol.48 , pp. 173-182
    • Gorski, J.C.1    Jones, D.R.2    Wrighton, S.A.3    Hall, S.D.4
  • 9
    • 0027163866 scopus 로고
    • Moclobemide treatment causes a substantial rise in the sparteine metabolic ratio
    • Gram LF, Brøsen K, and the Danish University Antidepresssant Group (1993) Moclobemide treatment causes a substantial rise in the sparteine metabolic ratio. Br J Clin Pharmacol 35: 649-652
    • (1993) Br J Clin Pharmacol , vol.35 , pp. 649-652
    • Gram, L.F.1    Brøsen, K.2
  • 10
    • 0029016328 scopus 로고
    • Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: A panel study
    • Gram LF, Guentert TW, Grange S, Viestisen K, Brøsen K (1995) Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: a panel study. Clin Pharmacol Ther 57:670-677
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 670-677
    • Gram, L.F.1    Guentert, T.W.2    Grange, S.3    Viestisen, K.4    Brøsen, K.5
  • 11
    • 0011795073 scopus 로고
    • Lack of an important influence of CYP2D6 oxidation status on the pharmacokinetics of moclobemide
    • Guentert TW, Grange S, Bock J, Waldburger R, Birnboeck H (1995) Lack of an important influence of CYP2D6 oxidation status on the pharmacokinetics of moclobemide. Clin Pharmaø col Ther 57:151
    • (1995) Clin Pharmacol Ther , vol.57 , pp. 151
    • Guentert, T.W.1    Grange, S.2    Bock, J.3    Waldburger, R.4    Birnboeck, H.5
  • 12
    • 0029941721 scopus 로고    scopus 로고
    • Automated determination of dextromethorphan and its main metabolites in human plasma by high performance-liquid chromatography and column switching
    • Härtter S, Baier D, Dingemanse J, Ziegler G, Hiemke C (1996) Automated determination of dextromethorphan and its main metabolites in human plasma by high performance-liquid chromatography and column switching. Ther Drug Monit 18: 297-303
    • (1996) Ther Drug Monit , vol.18 , pp. 297-303
    • Härtter, S.1    Baier, D.2    Dingemanse, J.3    Ziegler, G.4    Hiemke, C.5
  • 13
    • 0024565089 scopus 로고
    • Determination of dextromethorphan metabolizer phenotype in healthy volunteers
    • Hildebrand M, Seifert W, Reichenberger A (1989) Determination of dextromethorphan metabolizer phenotype in healthy volunteers. Eur J Clin Pharmacol 36: 315-318
    • (1989) Eur J Clin Pharmacol , vol.36 , pp. 315-318
    • Hildebrand, M.1    Seifert, W.2    Reichenberger, A.3
  • 14
    • 0027265750 scopus 로고
    • CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans
    • Jacqz-Aigrain E, Funck-Brentano C, Cresteil T (1993) CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans. Pharmacogenetics 3:197-204
    • (1993) Pharmacogenetics , vol.3 , pp. 197-204
    • Jacqz-Aigrain, E.1    Funck-Brentano, C.2    Cresteil, T.3
  • 16
    • 0027499806 scopus 로고
    • Primary and secondary oxidative metabolism of dextromethorphan
    • Kerry NL, Somogyi AA, Mikus G, Bochner K (1993) Primary and secondary oxidative metabolism of dextromethorphan. Biochem Pharmacol 45:833-839
    • (1993) Biochem Pharmacol , vol.45 , pp. 833-839
    • Kerry, N.L.1    Somogyi, A.A.2    Mikus, G.3    Bochner, K.4
  • 17
    • 0028038065 scopus 로고
    • The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: In vitro studies using human liver microsomes
    • Kerry NL, Somogyi AA, Bochner F, Mikus G (1994) The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes. Br J Clin Pharmacol 38:243-248
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 243-248
    • Kerry, N.L.1    Somogyi, A.A.2    Bochner, F.3    Mikus, G.4
  • 18
    • 0028874719 scopus 로고
    • Clinical pharmacokinetics of the monoamine oxidase-A inhibitor moclobemide
    • Mayersohn M, Guentert TW (1995) Clinical pharmacokinetics of the monoamine oxidase-A inhibitor moclobemide. Clin Pharmacokinet 29:292-332
    • (1995) Clin Pharmacokinet , vol.29 , pp. 292-332
    • Mayersohn, M.1    Guentert, T.W.2
  • 19
    • 0024535619 scopus 로고
    • Dextromethorphan: Polymorphic serum pattern of the O-demethylated and didemethylated metabolite in man
    • Mortimer O, Lindstrom B, Laurell H, Bergmann U, Rane A (1989) Dextromethorphan: polymorphic serum pattern of the O-demethylated and didemethylated metabolite in man. Br J Clin Pharmacol 27:223-227
    • (1989) Br J Clin Pharmacol , vol.27 , pp. 223-227
    • Mortimer, O.1    Lindstrom, B.2    Laurell, H.3    Bergmann, U.4    Rane, A.5
  • 20
    • 0022338958 scopus 로고
    • Polymorphic dextromethorphan metabolism: Co-segregation of oxidative O-demethylation with debrisoquin hydroxylation
    • Schmid B, Bircher J, Preisig R, Küpfer A (1985) Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation. Clin Pharmacol Ther 38:618-624
    • (1985) Clin Pharmacol Ther , vol.38 , pp. 618-624
    • Schmid, B.1    Bircher, J.2    Preisig, R.3    Küpfer, A.4
  • 21
    • 0028289040 scopus 로고
    • Clinical implications of genetic polymorphism in drug metabolism
    • Tucker GT (1994) Clinical implications of genetic polymorphism in drug metabolism. J Pharm Pharmacol 46[Suppl 1]: 417-424
    • (1994) J Pharm Pharmacol , vol.46 , Issue.1 SUPPL. , pp. 417-424
    • Tucker, G.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.